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ENZYME entry: EC 3.1.2.31

Accepted Name
dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase.
Reaction catalysed
dihydromonacolin L-[lovastatin nonaketide synthase] + H2O <=> dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]
Comment(s)
  • Dihydromonacolin L acid is synthesized while bound to an acyl-carrier protein domain of EC 2.3.1.161.
  • Since that enzyme lacks a thioesterase domain, release of the dihydromonacolin L acid moiety from the polyketide synthase requires this dedicated enzyme.
Cross-references
BRENDA3.1.2.31
EC2PDB3.1.2.31
ExplorEnz3.1.2.31
PRIAM enzyme-specific profiles3.1.2.31
KEGG Ligand Database for Enzyme Nomenclature3.1.2.31
IUBMB Enzyme Nomenclature3.1.2.31
IntEnz3.1.2.31
MEDLINEFind literature relating to 3.1.2.31
MetaCyc3.1.2.31
Rhea expert-curated reactions3.1.2.31
UniProtKB/Swiss-Prot
Q9Y7C9, LOVG_ASPTE;  Q0C8M2, LOVG_ASPTN;  Q3S2U0, MOKD_MONPI;  

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