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ENZYME entry: EC 3.1.21.3

Accepted Name
Type I site-specific deoxyribonuclease.
Alternative Name(s)
Type I restriction enzyme.
Reaction catalysed
Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed
Comment(s)
  • Large group of enzymes that have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine.
  • They recognize specific short DNA sequences and cleave at sites remote from the recognition sequence.
  • Multifunctional proteins which also catalyze the reactions of EC 2.1.1.72 and EC 2.1.1.73, with similar site specificity.
  • Formerly EC 3.1.24.1 and EC 3.1.24.2.
  • See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/
Cross-references
BRENDA3.1.21.3
EC2PDB3.1.21.3
ExplorEnz3.1.21.3
PRIAM enzyme-specific profiles3.1.21.3
KEGG Ligand Database for Enzyme Nomenclature3.1.21.3
IUBMB Enzyme Nomenclature3.1.21.3
IntEnz3.1.21.3
MEDLINEFind literature relating to 3.1.21.3
MetaCyc3.1.21.3
Rhea expert-curated reactions3.1.21.3
UniProtKB/Swiss-Prot
Q5HJH8, HSDR_STAAC;  Q99X26, HSDR_STAAM;  Q7A801, HSDR_STAAN;  
Q6GKB1, HSDR_STAAR;  Q6GCT1, HSDR_STAAS;  Q8NYL9, HSDR_STAAW;  
Q5HK76, HSDR_STAEQ;  Q4A127, HSDR_STAS1;  P10486, T1R1_ECOLX;  
Q57588, T1R1_METJA;  Q58611, T1R2_METJA;  Q07736, T1RA_ECOLX;  
Q47281, T1RE_ECOLX;  O05052, T1RH_HAEIN;  Q60295, T1RH_METJA;  
P08956, T1RK_ECOLI;  P17224, T1RP_ECOLX;  

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