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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Type I site-specific deoxyribonuclease.
Alternative Name(s)
Type I restriction enzyme.
Reaction catalysed
Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed
  • Large group of enzymes that have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine.
  • They recognize specific short DNA sequences and cleave at sites remote from the recognition sequence.
  • Multifunctional proteins which also catalyze the reactions of EC and EC, with similar site specificity.
  • Formerly EC and EC
  • See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/
PRIAM enzyme-specific profiles3.1.21.3
KEGG Ligand Database for Enzyme Nomenclature3.1.21.3
IUBMB Enzyme Nomenclature3.1.21.3
MEDLINEFind literature relating to
Q5HK76, HSDR_STAEQ;  Q4A127, HSDR_STAS1;  P10486, T1R1_ECOLX;  
Q07736, T1RA_ECOLX;  Q47281, T1RE_ECOLX;  O05052, T1RH_HAEIN;  
Q60295, T1RH_METJA;  P08956, T1RK_ECOLI;  P17224, T1RP_ECOLX;  
P75431, T1RX_MYCPN;  P75433, T1RY_MYCPN;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-