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ENZYME entry: EC 2.1.1.72

Accepted Name
Site-specific DNA-methyltransferase (adenine-specific).
Alternative Name(s)
Modification methylase.
N-6 adenine-specific DNA methylase.
Restriction-modification system.
Reaction catalysed
S-adenosyl-L-methionine + adenine in DNA <=> S-adenosyl-L-homocysteine + N-6-methyladenine in DNA
Comment(s)
  • This is a large group of enzymes, most of which form so-called 'restriction-modification systems', with nucleases that possess similar site specificity (the nucleases are listed as either EC 3.1.21.3, EC 3.1.21.4 and EC 3.1.21.5).
  • See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/
Cross-references
PROSITEPDOC00087
BRENDA2.1.1.72
EC2PDB2.1.1.72
ExplorEnz2.1.1.72
PRIAM enzyme-specific profiles2.1.1.72
KEGG Ligand Database for Enzyme Nomenclature2.1.1.72
IUBMB Enzyme Nomenclature2.1.1.72
IntEnz2.1.1.72
MEDLINEFind literature relating to 2.1.1.72
MetaCyc2.1.1.72
Rhea expert-curated reactions2.1.1.72
UniProtKB/Swiss-Prot
Q09956, DAMT1_CAEEL;  P21311, DMA7_ECOLX;  P12427, DMA_BPT2;  
P04392, DMA_BPT4;  P0AEE9, DMA_ECO57;  P0AEE8, DMA_ECOLI;  
P44431, DMA_HAEIN;  P0A292, DMA_SALTI;  P0DMP4, DMA_SALTM;  
P0DMP3, DMA_SALTY;  P45454, DMA_SERMA;  O33844, DMA_TREPA;  
A5F520, DMA_VIBC3;  P0C6Q8, DMA_VIBCH;  Q8N3J2, METL4_HUMAN;  
Q3U034, METL4_MOUSE;  P34720, MT1A_MORBO;  P34721, MT1B_MORBO;  
P25240, MT57_ECOLX;  P25201, MTA1_ACICA;  P58284, MTA1_AZOBR;  
B2S9Y5, MTB1_BRUA1;  Q2YMK2, MTB1_BRUA2;  A6WWI2, MTB1_BRUA4;  
P0C116, MTB1_BRUAB;  A9M916, MTB1_BRUC2;  Q8YFS6, MTB1_BRUME;  
A5VP58, MTB1_BRUO2;  B0CKH7, MTB1_BRUSI;  Q8G242, MTB1_BRUSU;  
P22772, MTB3_ANEAE;  P33563, MTBB_BACIU;  P0CAW2, MTC1_CAUVC;  
B8GZ33, MTC1_CAUVN;  P43423, MTC1_GEOSE;  Q01511, MTC1_PBCVC;  
P42828, MTC1_RHOHA;  P31118, MTC2_PBCV1;  P10835, MTC3_PBCVC;  
P04043, MTD21_STREE;  P09358, MTD22_STREE;  P00472, MTE1_ECOLX;  
P04393, MTE5_ECOLX;  P14827, MTEC_ENTCL;  P14871, MTF1_PLAOK;  
P20590, MTH1_HAEIF;  P29538, MTH1_HAEPA;  P00473, MTH2_HAEPH;  
P43871, MTH3_HAEIN;  P50193, MTHB_HAEPH;  P17744, MTHC_HAEIF;  
P44414, MTHD_HAEIN;  P25238, MTK1_KLEPN;  P35516, MTL1_LACLL;  
P50179, MTL21_LACLC;  P50178, MTL22_LACLC;  P50190, MTM1_MICAM;  
P23192, MTM2_MORBO;  Q58015, MTM3_METJA;  P43641, MTMU_MYCSP;  
P24582, MTN3_NEILA;  P05103, MTP7_PSEAI;  P00474, MTPS_PROST;  
P14751, MTR1_CERSP;  P52284, MTR1_PBCVX;  O30569, MTS1_RHIME;  
Q53609, MTS1_STRAL;  P29347, MTS1_STRSA;  P29749, MTT8_THET8;  
P14385, MTTA_THEAQ;  P43422, MTV1_GEOSE;  Q03055, MTV1_VIBS3;  
P96188, MTX1_XANCR;  Q9KVZ8, MTX1_XANVA;  P0DUF3, PGLX_BACCH;  
P0DUF9, PGLX_ECOHS;  P0DQP1, PGLX_LACCZ;  Q8CJM2, PGLX_STRCO;  
P10484, T1M1_ECOLX;  P75436, T1MD_MYCPN;  Q47282, T1ME_ECOLX;  
Q57168, T1MH_HAEIN;  Q60297, T1MH_METJA;  P08957, T1MK_ECOLI;  
Q47163, T1MP_ECOLX;  Q89Z59, T1M_BACTN;  P07989, T1M_SALPO;  
P40813, T1M_SALTY;  P25239, T257_ECOLX;  P71366, T3MH_HAEIN;  
P08763, T3MO_BPP1;  P12364, T3MO_ECOLX;  P40814, T3MO_SALTY;  
Q07605, T4BA_WEICA;  P75561, Y108_MYCPN;  P75451, Y111_MYCPN;  
Q58617, Y1220_METJA;  Q49400, Y184_MYCGE;  Q50290, Y198_MYCPN;  
Q60301, Y3402_METJA;  P28638, YHDJ_ECOLI;  P51715, YO13_BPHC1;  

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