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ENZYME

ENZYME entry: EC 3.1.3.48

PURL: https://purl.expasy.org/enzyme/EC/3.1.3.48
Accepted Name
protein-tyrosine-phosphatase
Alternative Name(s)
phosphotyrosine phosphatase
PTPase
Reaction catalysed
O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate
Comment(s)
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.
Cross-references
BRENDA3.1.3.48
EC2PDB3.1.3.48
ExplorEnz3.1.3.48
KEGG Ligand Database for Enzyme Nomenclature3.1.3.48
IUBMB Enzyme Nomenclature3.1.3.48
MEDLINEFind literature relating to 3.1.3.48
MetaCyc3.1.3.48
Rhea expert-curated reactions3.1.3.48
UniProtKB/Swiss-Prot
Q46630, AMSI_ERWAMP74313, ARSC_SYNY3P39852, CAPC_STAAU
A0A0R4IVA4, CC14A_DANREQ9UNH5, CC14A_HUMANQ6GQT0, CC14A_MOUSE
O60729, CC14B_HUMANQ6PFY9, CC14B_MOUSEA4D256, CC14C_HUMAN
A6N3Q4, CC14C_SYMSYP81299, CDC14_CAEELQ59NH8, CDC14_CANAL
Q5B323, CDC14_EMENIQ00684, CDC14_YEASTQ8GY31, CDC25_ARATH
Q16667, CDKN3_HUMANQ810P3, CDKN3_MOUSEQ9MYN5, CDKN3_PIG
B2RZ50, CDKN3_RATQ5APU2, CPP1_CANALQ3K0S8, CPSB_STRA1
Q04661, CPSB_STRA3P0A364, CPSB_STRA5P0C0T7, CPSB_STRAG
Q54518, CPSB_STREEQ9AHD4, CPSB_STRPNP29349, CSW_DROME
Q24708, CSW_DROVIQ1ZXG8, D1060_DICDIG5EGJ9, DEP1_CAEEL
Q75QN6, DPHS1_ARATHQ6B8I1, DS13A_HUMANQ6B8I0, DS13A_MOUSE
Q9UII6, DS13B_HUMANQ9QYJ7, DS13B_MOUSEQ1LWL2, DS22A_DANRE
Q566R7, DS22B_DANREQ0IID7, DUS10_BOVINQ9Y6W6, DUS10_HUMAN
Q9ESS0, DUS10_MOUSEQ9UNI6, DUS12_HUMANQ9D0T2, DUS12_MOUSE
Q9JIM4, DUS12_RATQ17QM8, DUS14_BOVINO95147, DUS14_HUMAN
Q9JLY7, DUS14_MOUSEQ9H1R2, DUS15_HUMANQ8R4V2, DUS15_MOUSE
B4F7B7, DUS15_RATQ9BY84, DUS16_HUMANQ5BIP9, DUS18_BOVIN
Q8NEJ0, DUS18_HUMANQ8VE01, DUS18_MOUSEQ5R8X2, DUS18_PONAB
Q6AXW7, DUS18_RATQ8WTR2, DUS19_HUMANQ8K4T5, DUS19_MOUSE
Q91790, DUS1A_XENLAQ9M8K7, DUS1B_ARATHQ90W58, DUS1B_XENLA
Q9ZR37, DUS1_ARATHP28562, DUS1_HUMANP28563, DUS1_MOUSE
Q64623, DUS1_RATQ9H596, DUS21_HUMANQ9D9D8, DUS21_MOUSE
Q9NRW4, DUS22_HUMANQ99N11, DUS22_MOUSEQ6GQJ8, DUS22_XENLA
Q5XHB2, DUS22_XENTRQ9BVJ7, DUS23_HUMANQ6NT99, DUS23_MOUSE
Q17QJ3, DUS26_BOVINQ9BV47, DUS26_HUMANQ9D700, DUS26_MOUSE
Q5R6H6, DUS26_PONABQ5FVI9, DUS26_RATQ4G0W2, DUS28_HUMAN
Q8BTR5, DUS28_MOUSEP0C598, DUS29_ANOCAP0C591, DUS29_BOVIN
P0C5A2, DUS29_CALMIP0C597, DUS29_CHICKQ29RA3, DUS29_DANRE
P0C5A0, DUS29_GASACP0C592, DUS29_HORSEQ68J44, DUS29_HUMAN
P0C593, DUS29_MONDOQ8BK84, DUS29_MOUSEP0C5A1, DUS29_ORYLA
P0C594, DUS29_PANTRP0C596, DUS29_PIGP0C595, DUS29_RAT
P0C599, DUS29_TAKRUQ4RQD3, DUS29_TETNGQ4KL92, DUS29_XENLA
A4IHU7, DUS29_XENTRP51452, DUS3_HUMANQ9D7X3, DUS3_MOUSE
Q5RD73, DUS3_PONABQ9PW71, DUS4_CHICKQ13115, DUS4_HUMAN
Q8BFV3, DUS4_MOUSEQ62767, DUS4_RATQ16690, DUS5_HUMAN
O54838, DUS5_RATQ2KJ36, DUS6_BOVINQ16828, DUS6_HUMAN
Q9DBB1, DUS6_MOUSEQ64346, DUS6_RATQ16829, DUS7_HUMAN
Q91Z46, DUS7_MOUSEQ63340, DUS7_RATQ13202, DUS8_HUMAN
O09112, DUS8_MOUSEQ99956, DUS9_HUMANQ9VVW5, DUSK3_DROME
Q9VWF4, DUSK4_DROMEV6CIV8, DUSL_CAEELQ55E39, DUSP1_DICDI
Q54R42, DUSP2_DICDIQ05923, DUSP2_HUMANQ05922, DUSP2_MOUSE
Q55BI8, DUSP3_DICDIQ54T76, DUSP4_DICDIQ556Y8, DUSPR_DICDI
Q9J592, DUSP_FOWPNA0A7H0DN78, DUSP_MONPVQ85297, DUSP_MYXVL
P80994, DUSP_RACVIP20495, DUSP_VACCCP07239, DUSP_VACCW
P0DOQ5, DUSP_VAR67P0DOQ6, DUSP_VARVG5EGU2, EAK6_CAEEL
Q1M199, EPM2A_CANLFO95278, EPM2A_HUMANQ9WUA5, EPM2A_MOUSE
Q91XQ2, EPM2A_RATQ7YTB0, EPP_BOMMOP58596, EPSP_RALN1
Q45408, EPSP_RALSLP0ACZ3, ETP_ECO57P0ACZ2, ETP_ECOLI
O17670, EYA1_CAEELQ9YHA0, EYA1_CHICKQ99502, EYA1_HUMAN
P97767, EYA1_MOUSEQ58DB6, EYA2_BOVINO00167, EYA2_HUMAN
O08575, EYA2_MOUSEQ9YH99, EYA3_CHICKQ99504, EYA3_HUMAN
P97480, EYA3_MOUSEQ9YH98, EYA4_CHICKO95677, EYA4_HUMAN
Q9Z191, EYA4_MOUSEQ9YHA1, EYA4_TAKRUO82162, EYA_ARATH
Q05201, EYA_DROMEQ9P7H1, FLP1_SCHPOQ79LY0, HOPD2_PSESM
Q8WZK3, IBP1_SCHPOQ84JU4, IBR5_ARATHQ05918, IPHP_NOSCO
Q9BMN8, LAR_CAEELP16621, LAR_DROMEQ86V88, MGDP1_HUMAN
Q9D967, MGDP1_MOUSEP40081, MGDP1_YEASTQ9C5S1, MKP1_ARATH
P30308, MPI1A_XENLAP30309, MPI1B_XENLAA7MBD1, MPIP1_BOVIN
O44552, MPIP1_CAEELP30304, MPIP1_HUMANP48964, MPIP1_MOUSE
P48965, MPIP1_RATO44628, MPIP2_CAEELP30305, MPIP2_HUMAN
P30306, MPIP2_MOUSEP48966, MPIP2_RATP30310, MPIP2_XENLA
A5D7P0, MPIP3_BOVINP30634, MPIP3_CAEELP30307, MPIP3_HUMAN
P48968, MPIP3_MESAUP48967, MPIP3_MOUSEQ29029, MPIP3_PIG
P30311, MPIP3_XENLAQ54QM6, MPIP_DICDIP20483, MPIP_DROME
P30303, MPIP_EMENIP06652, MPIP_SCHPOP23748, MPIP_YEAST
Q55CS7, MPL1_DICDIQ55CS8, MPL2_DICDIQ54Y32, MPL3_DICDI
P38590, MSG5_YEASTQ59XY9, OCA1_CANALQ6FSZ8, OCA1_CANGA
Q6BLZ8, OCA1_DEBHAQ75B37, OCA1_EREGSQ6CTE4, OCA1_KLULA
Q4P7L6, OCA1_MYCMDA5DE24, OCA1_PICGUA3LW52, OCA1_PICST
Q6C4X9, OCA1_YARLIA6ZRY1, OCA1_YEAS7P50946, OCA1_YEAST
Q12454, OCA6_YEASTQ2T9S4, PGP_BOVINQ5F4B1, PGP_CHICK
A6NDG6, PGP_HUMANQ8CHP8, PGP_MOUSED3ZDK7, PGP_RAT
O13453, PMP1_SCHPOP82890, PPAC1_DROMEP82891, PPAC2_DROME
P11064, PPAC_BOVINQ5ZKG5, PPAC_CHICKQ55GW2, PPAC_DICDI
P24666, PPAC_HUMANQ9D358, PPAC_MOUSEP81693, PPAC_PIG
Q5REM7, PPAC_PONABP41498, PPAC_RATP41893, PPAL_SCHPO
P40347, PPAL_YEASTA6H730, PPAP_BOVINP15309, PPAP_HUMAN
Q8CE08, PPAP_MOUSEP20646, PPAP_RATP38148, PPS1_YEAST
O61722, PRL1_DROMEQ4QEZ7, PRL1_LEIMAQ4CUJ8, PRL1_TRYCC
Q9FLZ5, PTEN1_ARATHG5EE01, PTEN_CAEELP60483, PTEN_CANLF
Q8T9S7, PTEN_DICDIP60484, PTEN_HUMANO08586, PTEN_MOUSE
O54857, PTEN_RATQ9PUT6, PTEN_XENLAQ90687, PTN11_CHICK
Q06124, PTN11_HUMANP35235, PTN11_MOUSEP41499, PTN11_RAT
Q05209, PTN12_HUMANP35831, PTN12_MOUSEQ12923, PTN13_HUMAN
Q64512, PTN13_MOUSEQ15678, PTN14_HUMANQ62130, PTN14_MOUSE
Q99952, PTN18_HUMANQ61152, PTN18_MOUSEO13016, PTN1_CHICK
P18031, PTN1_HUMANP35821, PTN1_MOUSEP20417, PTN1_RAT
Q4JDL3, PTN20_HUMANO55082, PTN20_MOUSEA1L1L3, PTN20_RAT
Q16825, PTN21_HUMANQ62136, PTN21_MOUSEQ62728, PTN21_RAT
Q9Y2R2, PTN22_HUMANP29352, PTN22_MOUSEQ9H3S7, PTN23_HUMAN
Q6PB44, PTN23_MOUSEO88902, PTN23_RATQ9LT75, PTN2A_ARATH
Q8H106, PTN2B_ARATHP17706, PTN2_HUMANQ06180, PTN2_MOUSE
P35233, PTN2_RATP26045, PTN3_HUMANA2ALK8, PTN3_MOUSE
P29074, PTN4_HUMANQ9WU22, PTN4_MOUSEP54829, PTN5_HUMAN
P54830, PTN5_MOUSEP35234, PTN5_RATP29350, PTN6_HUMAN
P29351, PTN6_MOUSEP81718, PTN6_RATP35236, PTN7_HUMAN
Q8BUM3, PTN7_MOUSEP49445, PTN7_RATP43378, PTN9_HUMAN
O35239, PTN9_MOUSEQ641Z2, PTN9_RATP35992, PTP10_DROME
P28202, PTP10_STYPLP28203, PTP11_STYPLP28204, PTP12_STYPL
P28205, PTP13_STYPLP28206, PTP14_STYPLP28207, PTP15_STYPL
P28208, PTP16_STYPLP28209, PTP17_STYPLP28210, PTP18_STYPL
P28211, PTP19_STYPLA0A6I8TCE0, PTP1_AEDAEO82656, PTP1_ARATH
P28191, PTP1_CAEELB0X4T2, PTP1_CULQUP34137, PTP1_DICDI
O10274, PTP1_NPVOPP28193, PTP1_STYPLP25044, PTP1_YEAST
P28212, PTP20_STYPLP28213, PTP21_STYPLP28214, PTP22_STYPL
P28215, PTP23_STYPLP28216, PTP24_STYPLP28217, PTP25_STYPL
P28218, PTP26_STYPLP28219, PTP27_STYPLG5EC24, PTP2_CAEEL
P34138, PTP2_DICDIO10273, PTP2_NPVOPP28194, PTP2_STYPL
P29461, PTP2_YEASTQ39491, PTP3_CHLMOP54637, PTP3_DICDI
P28195, PTP3_STYPLP40048, PTP3_YEASTP28192, PTP4_CAEEL
P28196, PTP4_STYPLP34442, PTP5_CAEELP28197, PTP5_STYPL
Q9W0G1, PTP61_DROMEP16620, PTP69_DROMEP28198, PTP6_STYPL
P28199, PTP7_STYPLP28200, PTP8_STYPLP35832, PTP99_DROME
P28201, PTP9_STYPLP65717, PTPA_MYCBOP9WIA0, PTPA_MYCTO
P9WIA1, PTPA_MYCTUQ2FFL4, PTPA_STAA3Q2FX12, PTPA_STAA8
Q2YU46, PTPA_STAABQ5HEP3, PTPA_STAACA0A0H3K9F2, PTPA_STAAE
Q99T00, PTPA_STAAMQ7A4S1, PTPA_STAANQ6GFH6, PTPA_STAAR
Q6G853, PTPA_STAASP0C5D2, PTPA_STAAUQ7A0I2, PTPA_STAAW
Q5HN53, PTPA_STAEQQ8CNQ1, PTPA_STAESQ4L7J1, PTPA_STAHJ
Q49YS6, PTPA_STAS1P53433, PTPA_STRCOI6WXK4, PTPB_MYCTU
Q2FF13, PTPB_STAA3Q2FWE3, PTPB_STAA8Q2YUL3, PTPB_STAAB
Q5HE85, PTPB_STAACQ99SE3, PTPB_STAAMQ7A4E1, PTPB_STAAN
Q6GEW0, PTPB_STAARQ6G7J5, PTPB_STAASP0C5D3, PTPB_STAAU
Q7A0B9, PTPB_STAAWQ5HMA8, PTPB_STAEQQ8CNI9, PTPB_STAES
Q4L7Z6, PTPB_STAHJQ49Z62, PTPB_STAS1Q5I146, PTPH2_MDBVW
Q5I145, PTPH3_MDBVWQ5I143, PTPH4_MDBVWQ9EMX1, PTPH_AMEPV
Q5UR74, PTPH_MIMIVQ5I139, PTPJ2_MDBVWQ5I137, PTPJ4_MDBVW
Q86BN8, PTPM1_DROMEQ8WUK0, PTPM1_HUMANQ66GT5, PTPM1_MOUSE
P0C089, PTPM1_RATQ5I128, PTPN1_MDBVWQ92932, PTPR2_HUMAN
O02695, PTPR2_MACNEP80560, PTPR2_MOUSEQ63475, PTPR2_RAT
P18433, PTPRA_HUMANP18052, PTPRA_MOUSEQ03348, PTPRA_RAT
P23467, PTPRB_HUMANB2RU80, PTPRB_MOUSEQ9IBD8, PTPRC_CYPCA
P08575, PTPRC_HUMANP06800, PTPRC_MOUSEP04157, PTPRC_RAT
P23468, PTPRD_HUMANQ64487, PTPRD_MOUSEP23469, PTPRE_HUMAN
P49446, PTPRE_MOUSEB2GV87, PTPRE_RATA7MBJ4, PTPRF_BOVIN
A4IFW2, PTPRF_DANREP10586, PTPRF_HUMANA2A8L5, PTPRF_MOUSE
Q64604, PTPRF_RATQ98936, PTPRG_CHICKP23470, PTPRG_HUMAN
Q05909, PTPRG_MOUSEQ9HD43, PTPRH_HUMANE9Q0N2, PTPRH_MOUSE
Q9W6V5, PTPRJ_CHICKQ12913, PTPRJ_HUMANQ64455, PTPRJ_MOUSE
Q15262, PTPRK_HUMANP35822, PTPRK_MOUSEP28827, PTPRM_HUMAN
P28828, PTPRM_MOUSEQ16827, PTPRO_HUMANE9Q612, PTPRO_MOUSE
Q15256, PTPRR_HUMANQ62132, PTPRR_MOUSEO08617, PTPRR_RAT
F1NWE3, PTPRS_CHICKQ13332, PTPRS_HUMANB0V2N1, PTPRS_MOUSE
Q64605, PTPRS_RATO14522, PTPRT_HUMANQ99M80, PTPRT_MOUSE
Q6YI48, PTPRU_CHICKB3DK56, PTPRU_DANREQ92729, PTPRU_HUMAN
B1AUH1, PTPRU_MOUSEP70289, PTPRV_MOUSEQ64612, PTPRV_RAT
P23471, PTPRZ_HUMANB9EKR1, PTPRZ_MOUSEQ62656, PTPRZ_RAT
H2KZM6, PTPR_CAEELP43078, PTPX_CANAWO52787, PTP_ACIJO
P24656, PTP_NPVACO13632, PVH1_SCHPOQ02256, PVH1_YEAST
P27574, PYP1_SCHPOP32586, PYP2_SCHPOP32587, PYP3_SCHPO
Q9SR62, RLPH2_ARATHQ8LEC0, RLPHL_ARATHP20402, ROB1_RHIRH
P49409, ROB2_RHIRHP09178, ROLB_NICGLP40479, SDP1_YEAST
Q5PEA9, SPTP_SALPAP74851, SPTP_SALTIP74873, SPTP_SALTY
Q8WYL5, SSH1_HUMANQ76I79, SSH1_MOUSEQ76I76, SSH2_HUMAN
Q5SW75, SSH2_MOUSEQ8TE77, SSH3_HUMANQ8K330, SSH3_MOUSE
Q5XIS1, SSH3_RATQ6NN85, SSH_DROMEQ6IVY4, SSH_XENLA
Q63HR2, TENS2_HUMANQ8CGB6, TENS2_MOUSEH2L045, TENSH_CAEEL
Q93096, TP4A1_HUMANQ9TSM6, TP4A1_MACFAQ63739, TP4A1_MOUSE
Q5R7J8, TP4A1_PONABQ78EG7, TP4A1_RATQ12974, TP4A2_HUMAN
O70274, TP4A2_MOUSEQ6P9X4, TP4A2_RATA2VDT1, TP4A3_BOVIN
O75365, TP4A3_HUMANQ9D658, TP4A3_MOUSEQ54DU9, TP4AA_DICDI
Q86IL4, TP4AB_DICDIA0A0H2ZFK2, TPBA_PSEABQ9HXC7, TPBA_PSEAE
Q9ZQP1, TPMT1_ARATHQ6NKR2, TPMT2_ARATHP56180, TPTE_HUMAN
Q03019, TWINE_DROMEQ8TF42, UBS3B_HUMANQ8BGG7, UBS3B_MOUSE
Q196Z3, VF197_IIV3Q91FX3, VF197_IIV6Q10038, VHP1_CAEEL
P54092, VP2_CAV26P54093, VP2_CAV82P69484, VP2_CAVC1
Q9IZU7, VP2_CAVCAP69485, VP2_CAVCIP0AAB3, WZB_ECO57
P0AAB2, WZB_ECOLIQ8Z5G5, WZB_SALTIQ9F7B2, WZB_SALTY
Q55535, Y328_SYNY3P40289, Y669_CUPNHO35016, YFKJ_BACSU
P34337, YK13_CAEELP42083, YKCA_CAEELP15273, YOPH_YEREN
P08538, YOPH_YERPSQ48451, YOR5_KLEPNO77334, YVH1_PLAF7
P96717, YWQE_BACSU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.3.-
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