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ENZYME

ENZYME entry: EC 3.1.3.48

Accepted Name
protein-tyrosine-phosphatase
Alternative Name(s)
phosphotyrosine phosphatase
PTPase
Reaction catalysed
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
Comment(s)
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.
Cross-references
BRENDA3.1.3.48
EC2PDB3.1.3.48
ExplorEnz3.1.3.48
PRIAM enzyme-specific profiles3.1.3.48
KEGG Ligand Database for Enzyme Nomenclature3.1.3.48
IUBMB Enzyme Nomenclature3.1.3.48
IntEnz3.1.3.48
MEDLINEFind literature relating to 3.1.3.48
MetaCyc3.1.3.48
Rhea expert-curated reactions3.1.3.48
UniProtKB/Swiss-Prot
Q46630, AMSI_ERWAMP74313, ARSC_SYNY3P39852, CAPC_STAAU
A0A0R4IVA4, CC14A_DANREQ9UNH5, CC14A_HUMANQ6GQT0, CC14A_MOUSE
O60729, CC14B_HUMANQ6PFY9, CC14B_MOUSEA4D256, CC14C_HUMAN
A6N3Q4, CC14C_SYMSYP81299, CDC14_CAEELQ59NH8, CDC14_CANAL
Q5B323, CDC14_EMENIQ00684, CDC14_YEASTQ8GY31, CDC25_ARATH
Q16667, CDKN3_HUMANQ810P3, CDKN3_MOUSEQ9MYN5, CDKN3_PIG
B2RZ50, CDKN3_RATQ5APU2, CPP1_CANALQ3K0S8, CPSB_STRA1
Q04661, CPSB_STRA3P0A364, CPSB_STRA5P0C0T7, CPSB_STRAG
Q54518, CPSB_STREEQ9AHD4, CPSB_STRPNP29349, CSW_DROME
Q24708, CSW_DROVIQ1ZXG8, D1060_DICDIG5EGJ9, DEP1_CAEEL
Q75QN6, DPHS1_ARATHQ6B8I1, DS13A_HUMANQ6B8I0, DS13A_MOUSE
Q9UII6, DS13B_HUMANQ9QYJ7, DS13B_MOUSEQ1LWL2, DS22A_DANRE
Q566R7, DS22B_DANREQ9ZVN4, DSP1_ARATHQ84MD6, DSP2_ARATH
Q0DX67, DSP2_ORYSJQ681Z2, DSP3_ARATHQ9FFD7, DSP5_ARATH
Q0IID7, DUS10_BOVINQ9Y6W6, DUS10_HUMANQ9ESS0, DUS10_MOUSE
Q9UNI6, DUS12_HUMANQ9D0T2, DUS12_MOUSEQ9JIM4, DUS12_RAT
Q17QM8, DUS14_BOVINO95147, DUS14_HUMANQ9JLY7, DUS14_MOUSE
Q9H1R2, DUS15_HUMANQ8R4V2, DUS15_MOUSEB4F7B7, DUS15_RAT
Q9BY84, DUS16_HUMANQ5BIP9, DUS18_BOVINQ8NEJ0, DUS18_HUMAN
Q8VE01, DUS18_MOUSEQ5R8X2, DUS18_PONABQ6AXW7, DUS18_RAT
Q8WTR2, DUS19_HUMANQ8K4T5, DUS19_MOUSEQ91790, DUS1A_XENLA
Q9M8K7, DUS1B_ARATHQ90W58, DUS1B_XENLAQ9ZR37, DUS1_ARATH
P28562, DUS1_HUMANP28563, DUS1_MOUSEQ64623, DUS1_RAT
Q9H596, DUS21_HUMANQ9D9D8, DUS21_MOUSEQ9NRW4, DUS22_HUMAN
Q99N11, DUS22_MOUSEQ6GQJ8, DUS22_XENLAQ5XHB2, DUS22_XENTR
Q9BVJ7, DUS23_HUMANQ6NT99, DUS23_MOUSEQ17QJ3, DUS26_BOVIN
Q9BV47, DUS26_HUMANQ9D700, DUS26_MOUSEQ5R6H6, DUS26_PONAB
Q5FVI9, DUS26_RATQ4G0W2, DUS28_HUMANQ8BTR5, DUS28_MOUSE
P0C598, DUS29_ANOCAP0C591, DUS29_BOVINP0C5A2, DUS29_CALMI
P0C597, DUS29_CHICKQ29RA3, DUS29_DANREP0C5A0, DUS29_GASAC
P0C592, DUS29_HORSEQ68J44, DUS29_HUMANP0C593, DUS29_MONDO
Q8BK84, DUS29_MOUSEP0C5A1, DUS29_ORYLAP0C594, DUS29_PANTR
P0C596, DUS29_PIGP0C595, DUS29_RATP0C599, DUS29_TAKRU
Q4RQD3, DUS29_TETNGQ4KL92, DUS29_XENLAA4IHU7, DUS29_XENTR
Q05923, DUS2_HUMANQ05922, DUS2_MOUSEP51452, DUS3_HUMAN
Q9D7X3, DUS3_MOUSEQ5RD73, DUS3_PONABQ9PW71, DUS4_CHICK
Q13115, DUS4_HUMANQ8BFV3, DUS4_MOUSEQ62767, DUS4_RAT
Q16690, DUS5_HUMANO54838, DUS5_RATQ2KJ36, DUS6_BOVIN
Q16828, DUS6_HUMANQ9DBB1, DUS6_MOUSEQ64346, DUS6_RAT
Q16829, DUS7_HUMANQ91Z46, DUS7_MOUSEQ63340, DUS7_RAT
Q13202, DUS8_HUMANO09112, DUS8_MOUSEQ99956, DUS9_HUMAN
Q9VVW5, DUSK3_DROMEQ9VWF4, DUSK4_DROMEV6CIV8, DUSL_CAEEL
Q55E39, DUSP1_DICDIQ54R42, DUSP2_DICDIQ55BI8, DUSP3_DICDI
Q54T76, DUSP4_DICDIQ556Y8, DUSPR_DICDIQ9J592, DUSP_FOWPN
A0A7H0DN78, DUSP_MONPVQ85297, DUSP_MYXVLP80994, DUSP_RACVI
P20495, DUSP_VACCCP07239, DUSP_VACCWP0DOQ5, DUSP_VAR67
P0DOQ6, DUSP_VARVG5EGU2, EAK6_CAEELQ1M199, EPM2A_CANLF
O95278, EPM2A_HUMANQ9WUA5, EPM2A_MOUSEQ91XQ2, EPM2A_RAT
Q7YTB0, EPP_BOMMOP58596, EPSP_RALN1Q45408, EPSP_RALSL
P0ACZ3, ETP_ECO57P0ACZ2, ETP_ECOLIO17670, EYA1_CAEEL
Q9YHA0, EYA1_CHICKQ99502, EYA1_HUMANP97767, EYA1_MOUSE
Q58DB6, EYA2_BOVINO00167, EYA2_HUMANO08575, EYA2_MOUSE
Q9YH99, EYA3_CHICKQ99504, EYA3_HUMANP97480, EYA3_MOUSE
Q9YH98, EYA4_CHICKO95677, EYA4_HUMANQ9Z191, EYA4_MOUSE
Q9YHA1, EYA4_TAKRUO82162, EYA_ARATHQ05201, EYA_DROME
Q9P7H1, FLP1_SCHPOQ79LY0, HOPD2_PSESMQ8WZK3, IBP1_SCHPO
Q84JU4, IBR5_ARATHQ05918, IPHP_NOSCOQ9BMN8, LAR_CAEEL
P16621, LAR_DROMEQ86V88, MGDP1_HUMANQ9D967, MGDP1_MOUSE
P40081, MGDP1_YEASTQ9C5S1, MKP1_ARATHP30308, MPI1A_XENLA
P30309, MPI1B_XENLAA7MBD1, MPIP1_BOVINO44552, MPIP1_CAEEL
P30304, MPIP1_HUMANP48964, MPIP1_MOUSEP48965, MPIP1_RAT
O44628, MPIP2_CAEELP30305, MPIP2_HUMANP30306, MPIP2_MOUSE
P48966, MPIP2_RATP30310, MPIP2_XENLAA5D7P0, MPIP3_BOVIN
P30634, MPIP3_CAEELP30307, MPIP3_HUMANP48968, MPIP3_MESAU
P48967, MPIP3_MOUSEQ29029, MPIP3_PIGP30311, MPIP3_XENLA
Q54QM6, MPIP_DICDIP20483, MPIP_DROMEP30303, MPIP_EMENI
P06652, MPIP_SCHPOP23748, MPIP_YEASTQ55CS7, MPL1_DICDI
Q55CS8, MPL2_DICDIQ54Y32, MPL3_DICDIP38590, MSG5_YEAST
Q22712, MTMR3_CAEELQ13615, MTMR3_HUMANQ8K296, MTMR3_MOUSE
Q5PQT2, MTMR3_RATQ9NYA4, MTMR4_HUMANQ91XS1, MTMR4_MOUSE
Q7ZXF1, MTMR4_XENLAQ59XY9, OCA1_CANALQ6FSZ8, OCA1_CANGA
Q6BLZ8, OCA1_DEBHAQ75B37, OCA1_EREGSQ6CTE4, OCA1_KLULA
A5DE24, OCA1_PICGUA3LW52, OCA1_PICSTQ4P7L6, OCA1_USTMA
Q6C4X9, OCA1_YARLIA6ZRY1, OCA1_YEAS7P50946, OCA1_YEAST
Q12454, OCA6_YEASTQ940L5, PDSP4_ARATHQ2T9S4, PGP_BOVIN
Q5F4B1, PGP_CHICKA6NDG6, PGP_HUMANQ8CHP8, PGP_MOUSE
D3ZDK7, PGP_RATO13453, PMP1_SCHPOP82890, PPAC1_DROME
P82891, PPAC2_DROMEP11064, PPAC_BOVINQ5ZKG5, PPAC_CHICK
Q55GW2, PPAC_DICDIP24666, PPAC_HUMANQ9D358, PPAC_MOUSE
P81693, PPAC_PIGQ5REM7, PPAC_PONABP41498, PPAC_RAT
P41893, PPAL_SCHPOP40347, PPAL_YEASTA6H730, PPAP_BOVIN
P15309, PPAP_HUMANQ8CE08, PPAP_MOUSEP20646, PPAP_RAT
P38148, PPS1_YEASTO61722, PRL1_DROMEQ4QEZ7, PRL1_LEIMA
Q4CUJ8, PRL1_TRYCCQ9FLZ5, PTEN1_ARATHG5EE01, PTEN_CAEEL
P60483, PTEN_CANLFQ8T9S7, PTEN_DICDIP60484, PTEN_HUMAN
O08586, PTEN_MOUSEO54857, PTEN_RATQ9PUT6, PTEN_XENLA
Q90687, PTN11_CHICKQ06124, PTN11_HUMANP35235, PTN11_MOUSE
P41499, PTN11_RATQ05209, PTN12_HUMANP35831, PTN12_MOUSE
Q12923, PTN13_HUMANQ64512, PTN13_MOUSEQ15678, PTN14_HUMAN
Q62130, PTN14_MOUSEQ99952, PTN18_HUMANQ61152, PTN18_MOUSE
O13016, PTN1_CHICKP18031, PTN1_HUMANP35821, PTN1_MOUSE
P20417, PTN1_RATQ4JDL3, PTN20_HUMANO55082, PTN20_MOUSE
A1L1L3, PTN20_RATQ16825, PTN21_HUMANQ62136, PTN21_MOUSE
Q62728, PTN21_RATQ9Y2R2, PTN22_HUMANP29352, PTN22_MOUSE
Q9H3S7, PTN23_HUMANQ6PB44, PTN23_MOUSEO88902, PTN23_RAT
Q9LT75, PTN2A_ARATHQ8H106, PTN2B_ARATHP17706, PTN2_HUMAN
Q06180, PTN2_MOUSEP35233, PTN2_RATP26045, PTN3_HUMAN
A2ALK8, PTN3_MOUSEP29074, PTN4_HUMANQ9WU22, PTN4_MOUSE
P54829, PTN5_HUMANP54830, PTN5_MOUSEP35234, PTN5_RAT
P29350, PTN6_HUMANP29351, PTN6_MOUSEP81718, PTN6_RAT
P35236, PTN7_HUMANQ8BUM3, PTN7_MOUSEP49445, PTN7_RAT
P43378, PTN9_HUMANO35239, PTN9_MOUSEQ641Z2, PTN9_RAT
P35992, PTP10_DROMEP28202, PTP10_STYPLP28203, PTP11_STYPL
P28204, PTP12_STYPLP28205, PTP13_STYPLP28206, PTP14_STYPL
P28207, PTP15_STYPLP28208, PTP16_STYPLP28209, PTP17_STYPL
P28210, PTP18_STYPLP28211, PTP19_STYPLO82656, PTP1_ARATH
P28191, PTP1_CAEELP34137, PTP1_DICDIO10274, PTP1_NPVOP
P28193, PTP1_STYPLP25044, PTP1_YEASTP28212, PTP20_STYPL
P28213, PTP21_STYPLP28214, PTP22_STYPLP28215, PTP23_STYPL
P28216, PTP24_STYPLP28217, PTP25_STYPLP28218, PTP26_STYPL
P28219, PTP27_STYPLG5EC24, PTP2_CAEELP34138, PTP2_DICDI
O10273, PTP2_NPVOPP28194, PTP2_STYPLP29461, PTP2_YEAST
Q39491, PTP3_CHLMOP54637, PTP3_DICDIP28195, PTP3_STYPL
P40048, PTP3_YEASTP28192, PTP4_CAEELP28196, PTP4_STYPL
P34442, PTP5_CAEELP28197, PTP5_STYPLQ9W0G1, PTP61_DROME
P16620, PTP69_DROMEP28198, PTP6_STYPLP28199, PTP7_STYPL
P28200, PTP8_STYPLP35832, PTP99_DROMEP28201, PTP9_STYPL
P65717, PTPA_MYCBOP9WIA0, PTPA_MYCTOP9WIA1, PTPA_MYCTU
Q2FFL4, PTPA_STAA3Q2FX12, PTPA_STAA8Q2YU46, PTPA_STAAB
Q5HEP3, PTPA_STAACA0A0H3K9F2, PTPA_STAAEQ99T00, PTPA_STAAM
Q7A4S1, PTPA_STAANQ6GFH6, PTPA_STAARQ6G853, PTPA_STAAS
P0C5D2, PTPA_STAAUQ7A0I2, PTPA_STAAWQ5HN53, PTPA_STAEQ
Q8CNQ1, PTPA_STAESQ4L7J1, PTPA_STAHJQ49YS6, PTPA_STAS1
P53433, PTPA_STRCOI6WXK4, PTPB_MYCTUQ2FF13, PTPB_STAA3
Q2FWE3, PTPB_STAA8Q2YUL3, PTPB_STAABQ5HE85, PTPB_STAAC
Q99SE3, PTPB_STAAMQ7A4E1, PTPB_STAANQ6GEW0, PTPB_STAAR
Q6G7J5, PTPB_STAASP0C5D3, PTPB_STAAUQ7A0B9, PTPB_STAAW
Q5HMA8, PTPB_STAEQQ8CNI9, PTPB_STAESQ4L7Z6, PTPB_STAHJ
Q49Z62, PTPB_STAS1Q5I146, PTPH2_MDBVWQ5I145, PTPH3_MDBVW
Q5I143, PTPH4_MDBVWQ9EMX1, PTPH_AMEPVQ5UR74, PTPH_MIMIV
Q5I139, PTPJ2_MDBVWQ5I137, PTPJ4_MDBVWQ86BN8, PTPM1_DROME
Q8WUK0, PTPM1_HUMANQ66GT5, PTPM1_MOUSEP0C089, PTPM1_RAT
Q5I128, PTPN1_MDBVWQ92932, PTPR2_HUMANO02695, PTPR2_MACNE
P80560, PTPR2_MOUSEQ63475, PTPR2_RATP18433, PTPRA_HUMAN
P18052, PTPRA_MOUSEQ03348, PTPRA_RATP23467, PTPRB_HUMAN
B2RU80, PTPRB_MOUSEQ9IBD8, PTPRC_CYPCAP08575, PTPRC_HUMAN
P06800, PTPRC_MOUSEP04157, PTPRC_RATP23468, PTPRD_HUMAN
Q64487, PTPRD_MOUSEP23469, PTPRE_HUMANP49446, PTPRE_MOUSE
B2GV87, PTPRE_RATA7MBJ4, PTPRF_BOVINA4IFW2, PTPRF_DANRE
P10586, PTPRF_HUMANA2A8L5, PTPRF_MOUSEQ64604, PTPRF_RAT
Q98936, PTPRG_CHICKP23470, PTPRG_HUMANQ05909, PTPRG_MOUSE
Q9HD43, PTPRH_HUMANE9Q0N2, PTPRH_MOUSEQ9W6V5, PTPRJ_CHICK
Q12913, PTPRJ_HUMANQ64455, PTPRJ_MOUSEQ15262, PTPRK_HUMAN
P35822, PTPRK_MOUSEP28827, PTPRM_HUMANP28828, PTPRM_MOUSE
Q16827, PTPRO_HUMANE9Q612, PTPRO_MOUSEQ9UMZ3, PTPRQ_HUMAN
P0C5E4, PTPRQ_MOUSEO88488, PTPRQ_RATQ15256, PTPRR_HUMAN
Q62132, PTPRR_MOUSEO08617, PTPRR_RATF1NWE3, PTPRS_CHICK
Q13332, PTPRS_HUMANB0V2N1, PTPRS_MOUSEQ64605, PTPRS_RAT
O14522, PTPRT_HUMANQ99M80, PTPRT_MOUSEQ6YI48, PTPRU_CHICK
B3DK56, PTPRU_DANREQ92729, PTPRU_HUMANB1AUH1, PTPRU_MOUSE
P70289, PTPRV_MOUSEQ64612, PTPRV_RATP23471, PTPRZ_HUMAN
B9EKR1, PTPRZ_MOUSEQ62656, PTPRZ_RATH2KZM6, PTPR_CAEEL
P43078, PTPX_CANAWO52787, PTP_ACIJOP24656, PTP_NPVAC
O13632, PVH1_SCHPOQ02256, PVH1_YEASTP27574, PYP1_SCHPO
P32586, PYP2_SCHPOP32587, PYP3_SCHPOQ9SR62, RLPH2_ARATH
Q8LEC0, RLPHL_ARATHP20402, ROB1_RHIRHP49409, ROB2_RHIRH
P09178, ROLB_NICGLP40479, SDP1_YEASTQ5PEA9, SPTP_SALPA
P74851, SPTP_SALTIP74873, SPTP_SALTYQ8WYL5, SSH1_HUMAN
Q76I79, SSH1_MOUSEQ76I76, SSH2_HUMANQ5SW75, SSH2_MOUSE
Q8TE77, SSH3_HUMANQ8K330, SSH3_MOUSEQ5XIS1, SSH3_RAT
Q6NN85, SSH_DROMEQ6IVY4, SSH_XENLAQ63HR2, TENS2_HUMAN
Q8CGB6, TENS2_MOUSEH2L045, TENSH_CAEELQ93096, TP4A1_HUMAN
Q9TSM6, TP4A1_MACFAQ63739, TP4A1_MOUSEQ5R7J8, TP4A1_PONAB
Q78EG7, TP4A1_RATQ12974, TP4A2_HUMANO70274, TP4A2_MOUSE
Q6P9X4, TP4A2_RATA2VDT1, TP4A3_BOVINO75365, TP4A3_HUMAN
Q9D658, TP4A3_MOUSEQ54DU9, TP4AA_DICDIQ86IL4, TP4AB_DICDI
A0A0H2ZFK2, TPBA_PSEABQ9HXC7, TPBA_PSEAEQ9ZQP1, TPMT1_ARATH
Q6NKR2, TPMT2_ARATHP56180, TPTE_HUMANQ03019, TWINE_DROME
Q8TF42, UBS3B_HUMANQ8BGG7, UBS3B_MOUSEQ196Z3, VF197_IIV3
Q91FX3, VF197_IIV6Q10038, VHP1_CAEELP54092, VP2_CAV26
P54093, VP2_CAV82P69484, VP2_CAVC1Q9IZU7, VP2_CAVCA
P69485, VP2_CAVCIP0AAB3, WZB_ECO57P0AAB2, WZB_ECOLI
Q8Z5G5, WZB_SALTIQ9F7B2, WZB_SALTYQ55535, Y328_SYNY3
P40289, Y669_CUPNHO35016, YFKJ_BACSUP34337, YK13_CAEEL
P42083, YKCA_CAEELP15273, YOPH_YERENP08538, YOPH_YERPS
Q48451, YOR5_KLEPNO77334, YVH1_PLAF7P96717, YWQE_BACSU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.3.-
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