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ENZYME

ENZYME entry: EC 2.7.10.2

Accepted Name
non-specific protein-tyrosine kinase
Alternative Name(s)
cytoplasmic protein tyrosine kinase
Reaction catalysed
ATP + L-tyrosyl-[protein] <=> ADP + H(+) + O-phospho-L-tyrosyl-[protein]
Comment(s)
  • Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain.
  • In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families.
  • Formerly EC 2.7.1.112.
Cross-references
BRENDA2.7.10.2
EC2PDB2.7.10.2
ExplorEnz2.7.10.2
PRIAM enzyme-specific profiles2.7.10.2
KEGG Ligand Database for Enzyme Nomenclature2.7.10.2
IUBMB Enzyme Nomenclature2.7.10.2
IntEnz2.7.10.2
MEDLINEFind literature relating to 2.7.10.2
MetaCyc2.7.10.2
Rhea expert-curated reactions2.7.10.2
UniProtKB/Swiss-Prot
P03949, ABL1_CAEELP00519, ABL1_HUMANP00520, ABL1_MOUSE
P42684, ABL2_HUMANQ4JIM5, ABL2_MOUSEP11681, ABL_CALVI
P00522, ABL_DROMEP10447, ABL_FSVHYP00521, ABL_MLVAB
Q17R13, ACK1_BOVINQ07912, ACK1_HUMANO54967, ACK1_MOUSE
Q5U2X5, ACK1_RATQ9I7F7, ACKL_DROMEQ9VZI2, ACK_DROME
G5EBZ8, ARK1_CAEELA2BIL7, BAZ1B_DANREQ9UIG0, BAZ1B_HUMAN
Q9Z277, BAZ1B_MOUSEA8DZJ1, BAZ1B_XENLAP51451, BLK_HUMAN
P16277, BLK_MOUSEP51813, BMX_HUMANP97504, BMX_MOUSE
P08630, BTKL_DROMEQ8JH64, BTK_CHICKQ06187, BTK_HUMAN
P35991, BTK_MOUSEP39851, CAPB_STAAUQ3K0T0, CPSD_STRA1
Q04663, CPSD_STRA3Q9AFI1, CPSD_STRA5P0C0T9, CPSD_STRAG
Q54520, CPSD_STREEQ9AHD2, CPSD_STRPNG5ECJ6, CSK1_CAEEL
F4HVG8, CSK_ARATHQ0VBZ0, CSK_BOVINP41239, CSK_CHICK
P41240, CSK_HUMANP41241, CSK_MOUSEP32577, CSK_RAT
P19525, E2AK2_HUMANQ03963, E2AK2_MOUSEQ63184, E2AK2_RAT
Q00944, FAK1_CHICKQ05397, FAK1_HUMANP34152, FAK1_MOUSE
O35346, FAK1_RATQ91738, FAK1_XENLAQ14289, FAK2_HUMAN
Q9QVP9, FAK2_MOUSEP70600, FAK2_RATQ9TTY2, FER_CANLF
P18106, FER_DROMEP16591, FER_HUMANP70451, FER_MOUSE
P09760, FER_RATP14238, FES_FELCAP00542, FES_FSVGA
P00543, FES_FSVSTP07332, FES_HUMANP16879, FES_MOUSE
P00544, FGR_FSVGRP09769, FGR_HUMANP14234, FGR_MOUSE
Q6P6U0, FGR_RATP00541, FPS_AVISPP00530, FPS_FUJSV
Q22146, FRK1_CAEELP42685, FRK_HUMANQ922K9, FRK_MOUSE
Q62662, FRK_RATQ6EWH2, FYNA_DANREF1RDG9, FYNB_DANRE
A0JNB0, FYN_BOVINQ05876, FYN_CHICKP06241, FYN_HUMAN
P39688, FYN_MOUSEA1Y2K1, FYN_PIGQ62844, FYN_RAT
P13406, FYN_XENLAP27446, FYN_XIPHEP08631, HCK_HUMAN
Q95M30, HCK_MACFAP08103, HCK_MOUSEP50545, HCK_RAT
P53356, HTK16_HYDVUQ08881, ITK_HUMANQ03526, ITK_MOUSE
Q09178, JAK1_CYPCAO12990, JAK1_DANREP23458, JAK1_HUMAN
P52332, JAK1_MOUSEQ75R65, JAK2_CHICKO60674, JAK2_HUMAN
Q62120, JAK2_MOUSEO19064, JAK2_PIGQ5RB23, JAK2_PONAB
Q62689, JAK2_RATP52333, JAK3_HUMANQ62137, JAK3_MOUSE
Q63272, JAK3_RATQ24592, JAK_DROMEQ5PU49, KPCD_CANLF
Q05655, KPCD_HUMANP28867, KPCD_MOUSEP11979, KPYM_FELCA
P14618, KPYM_HUMANP52480, KPYM_MOUSEP11974, KPYM_RABIT
P11980, KPYM_RATF1N9Y5, KSYK_CHICKP43405, KSYK_HUMAN
P48025, KSYK_MOUSEQ00655, KSYK_PIGQ64725, KSYK_RAT
Q5PXS1, LCK_AOTNAP42683, LCK_CHICKP06239, LCK_HUMAN
P06240, LCK_MOUSEQ01621, LCK_RATQ95KR7, LCK_SAISC
P07948, LYN_HUMANP25911, LYN_MOUSEQ07014, LYN_RAT
Q1DB00, MASK_MYXXDP42679, MATK_HUMANP41242, MATK_MOUSE
P41243, MATK_RATQ14680, MELK_HUMANQ61846, MELK_MOUSE
Q504Y2, PKDCC_HUMANQ5RJI4, PKDCC_MOUSEQ8H1G6, PTI11_ARATH
O49339, PTI12_ARATHB9DFG5, PTI13_ARATHQ13882, PTK6_HUMAN
Q64434, PTK6_MOUSEQ9HUF7, RFAP_PSEAEQ3SZJ2, RIPK2_BOVIN
O43353, RIPK2_HUMANP58801, RIPK2_MOUSEP23049, SEA_AVIET
Q24145, SHARK_DROMEQ10925, SID3_CAEELA8WZ92, SPE8_CAEBR
O01798, SPE8_CAEELP42687, SPK1_GIRTIP18160, SPLA_DICDI
P18161, SPLB_DICDIG5EE56, SRC1_CAEELP13115, SRC1_XENLA
O45539, SRC2_CAEELP13116, SRC2_XENLAQ9V9J3, SRC42_DROME
P00528, SRC64_DROMEP15054, SRC_AVIS2P00525, SRC_AVISR
P14084, SRC_AVISSP14085, SRC_AVISTP00523, SRC_CHICK
Q1JPZ3, SRC_DANREP12931, SRC_HUMANP05480, SRC_MOUSE
Q9WUD9, SRC_RATP25020, SRC_RSVH1P00526, SRC_RSVP
P31693, SRC_RSVPAP00524, SRC_RSVSAP63185, SRC_RSVSE
P42686, SRK1_SPOLAP42688, SRK2_SPOLAP42689, SRK3_SPOLA
P42690, SRK4_SPOLAQ9H3Y6, SRMS_HUMANQ62270, SRMS_MOUSE
O75716, STK16_HUMANO88697, STK16_MOUSEP57760, STK16_RAT
P17713, STK_HYDVUQ6J9G0, STYK1_HUMANQ6J9G1, STYK1_MOUSE
P42680, TEC_HUMANP24604, TEC_MOUSEQ13470, TNK1_HUMAN
Q99ML2, TNK1_MOUSEP42681, TXK_HUMANP42682, TXK_MOUSE
P29597, TYK2_HUMANQ9R117, TYK2_MOUSEO36385, VG36_ALHV1
Q8AYK6, WEE1A_XENLAQ8QGV2, WEE1B_XENLAQ8L4H0, WEE1_ARATH
P54350, WEE1_DROMEP30291, WEE1_HUMANP47810, WEE1_MOUSE
Q6Z829, WEE1_ORYSJQ63802, WEE1_RATP07527, WEE1_SCHPO
P47817, WEE2A_XENLAO57473, WEE2B_XENLAQ6DFE0, WEE2C_XENLA
D2HHP1, WEE2_AILMEE2RSS3, WEE2_CANLFE1BTE1, WEE2_CHICK
Q1LX51, WEE2_DANREP0C1S8, WEE2_HUMANQ66JT0, WEE2_MOUSE
A4PES0, WEE2_PIGA4QNA8, WEE2_XENTRQ9LSC2, Y3589_ARATH
P00527, YES_AVISYQ28923, YES_CANLFP09324, YES_CHICK
A1A5H8, YES_DANREP07947, YES_HUMANQ04736, YES_MOUSE
F1LM93, YES_RATP10936, YES_XENLAP27447, YES_XIPHE
Q02977, YRK_CHICKQ54G28, YTYK1_DICDIQ54R58, YTYK2_DICDI
P71051, YVEL_BACSUP96716, YWQD_BACSUQ11112, YX05_CAEEL
P43403, ZAP70_HUMANP43404, ZAP70_MOUSE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.10.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-