| Accepted Name |
|---|
| phosphatidylinositol-4,5-bisphosphate 4-phosphatase.
|
| Alternative Name(s) |
|---|
| PtdIns-4,5-P2 4-phosphatase. |
| Reaction catalysed |
|---|
| a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate |
| Comment(s) |
|---|
- Two pathways exist in mammalian cells to degrade 1-phosphatidyl-
1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2].
- One is catalyzed by this enzyme and the other by EC 3.1.3.36, where
the product is PtdIns4P.
- The enzyme from human is specific for PtdIns(4,5)P2 as substrate,
as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2,
PtdIns5P, PtdIns4P or PtdIns3P.
- In humans, the enzyme is localized to late endosomal/lysosomal
membranes.
- It can control nuclear levels of PtdIns5P and thereby control p53-
dependent apoptosis.
- Formerly EC 3.1.3.n3.
|
| Cross-references |
|---|
| BRENDA | 3.1.3.78 |
| EC2PDB | 3.1.3.78 |
| ExplorEnz | 3.1.3.78 |
| PRIAM enzyme-specific profiles | 3.1.3.78 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.1.3.78 |
| IUBMB Enzyme Nomenclature | 3.1.3.78 |
| IntEnz | 3.1.3.78 |
| MEDLINE | Find literature relating to 3.1.3.78 |
| MetaCyc | 3.1.3.78 |
| Rhea expert-curated reactions | 3.1.3.78 |
| UniProtKB/Swiss-Prot |
| Q07566, IPGD_SHIFL; | Q55286, IPGD_SHISO; | Q86T03, PP4P1_HUMAN; |
| Q4R6W2, PP4P1_MACFA; | Q3TWL2, PP4P1_MOUSE; | Q5PPM8, PP4P1_RAT; |
| Q5XKA6, PP4P1_XENLA; | Q3SZ48, PP4P2_BOVIN; | Q8N4L2, PP4P2_HUMAN; |
| Q9CZX7, PP4P2_MOUSE; | Q4V888, PP4P2_RAT; | Q5EAU3, PP4P2_XENLA; |
| Q6DIE4, PP4P2_XENTR; | Q32PR0, T55BA_DANRE; | Q66I51, T55BB_DANRE; |
|