ENZYME entry: EC 3.1.3.78
Accepted Name |
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase.
|
Alternative Name(s) |
PtdIns-4,5-P(2) 4-phosphatase. |
Reaction catalysed |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O <=> 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate |
Comment(s) |
- Two pathways exist in mammalian cells to degrade 1-phosphatidyl-
1D-myo-inositol 4,5-bisphosphate (PtdIns(4,5)P(2)).
- One is catalyzed by this enzyme and the other by EC 3.1.3.36, where
the product is PtdIns4P.
- The enzyme from human is specific for PtdIns(4,5)P(2) as substrate,
as it cannot use PtdIns(3,4,5)P(3), PtdIns(3,4)P(2), PtdIns(3,5)P(2),
PtdIns5P, PtdIns4P or PtdIns3P.
- In humans, the enzyme is localized to late endosomal/lysosomal
membranes.
- It can control nuclear levels of PtdIns5P and thereby control p53-
dependent apoptosis.
- Formerly EC 3.1.3.n3.
|
Cross-references |
BRENDA | 3.1.3.78 |
EC2PDB | 3.1.3.78 |
ExplorEnz | 3.1.3.78 |
PRIAM enzyme-specific profiles | 3.1.3.78 |
KEGG Ligand Database for Enzyme Nomenclature | 3.1.3.78 |
IUBMB Enzyme Nomenclature | 3.1.3.78 |
IntEnz | 3.1.3.78 |
MEDLINE | Find literature relating to 3.1.3.78 |
MetaCyc | 3.1.3.78 |
Rhea expert-curated reactions | 3.1.3.78 |
UniProtKB/Swiss-Prot |
Q07566, IPGD_SHIFL; | Q55286, IPGD_SHISO; | Q86T03, PP4P1_HUMAN; |
Q4R6W2, PP4P1_MACFA; | Q3TWL2, PP4P1_MOUSE; | Q5PPM8, PP4P1_RAT; |
Q5XKA6, PP4P1_XENLA; | Q3SZ48, PP4P2_BOVIN; | Q8N4L2, PP4P2_HUMAN; |
Q9CZX7, PP4P2_MOUSE; | Q4V888, PP4P2_RAT; | Q5EAU3, PP4P2_XENLA; |
Q6DIE4, PP4P2_XENTR; | Q32PR0, T55BA_DANRE; | Q66I51, T55BB_DANRE; |
|
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