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ENZYME entry: EC 3.1.3.78

Accepted Name
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase.
Alternative Name(s)
PtdIns-4,5-P(2) 4-phosphatase.
Reaction catalysed
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O <=> 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
Comment(s)
  • Two pathways exist in mammalian cells to degrade 1-phosphatidyl- 1D-myo-inositol 4,5-bisphosphate (PtdIns(4,5)P(2)).
  • One is catalyzed by this enzyme and the other by EC 3.1.3.36, where the product is PtdIns4P.
  • The enzyme from human is specific for PtdIns(4,5)P(2) as substrate, as it cannot use PtdIns(3,4,5)P(3), PtdIns(3,4)P(2), PtdIns(3,5)P(2), PtdIns5P, PtdIns4P or PtdIns3P.
  • In humans, the enzyme is localized to late endosomal/lysosomal membranes.
  • It can control nuclear levels of PtdIns5P and thereby control p53- dependent apoptosis.
  • Formerly EC 3.1.3.n3.
Cross-references
BRENDA3.1.3.78
EC2PDB3.1.3.78
ExplorEnz3.1.3.78
PRIAM enzyme-specific profiles3.1.3.78
KEGG Ligand Database for Enzyme Nomenclature3.1.3.78
IUBMB Enzyme Nomenclature3.1.3.78
IntEnz3.1.3.78
MEDLINEFind literature relating to 3.1.3.78
MetaCyc3.1.3.78
Rhea expert-curated reactions3.1.3.78
UniProtKB/Swiss-Prot
Q07566, IPGD_SHIFL;  Q55286, IPGD_SHISO;  Q86T03, PP4P1_HUMAN;  
Q4R6W2, PP4P1_MACFA;  Q3TWL2, PP4P1_MOUSE;  Q5PPM8, PP4P1_RAT;  
Q5XKA6, PP4P1_XENLA;  Q3SZ48, PP4P2_BOVIN;  Q8N4L2, PP4P2_HUMAN;  
Q9CZX7, PP4P2_MOUSE;  Q4V888, PP4P2_RAT;  Q5EAU3, PP4P2_XENLA;  
Q6DIE4, PP4P2_XENTR;  Q32PR0, T55BA_DANRE;  Q66I51, T55BB_DANRE;  

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