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ENZYME

ENZYME entry: EC 3.1.3.36

Accepted Name
phosphoinositide 5-phosphatase
Alternative Name(s)
diphosphoinositide phosphatase
inositol 1,4,5-triphosphate 5-phosphomonoesterase
inositol triphosphate 5-phosphomonoesterase
IP3 phosphatase
phosphatidylinositol 4,5-bisphosphate phosphatase
phosphatidylinositol-bisphosphatase
phosphatidyl-inositol-bisphosphate phosphatase
phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase
polyphosphoinositol lipid 5-phosphatase
PtdIns(4,5)P2 phosphatase
triphosphoinositide phosphatase
triphosphoinositide phosphomonoesterase
type II inositol-1,4,5-trisphosphate 5-phosphatase
type II inositol polyphosphate 5-phosphatase
Reaction catalysed
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate
Comment(s)
  • These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3 and/or Ins(1,3,4,5)P4.
  • They are a diverse family of enzymes, with differing abilities to catalyze two or more of the four reactions listed.
  • They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo.
  • All of them can use either or both of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 as substrates; this is the main property that distinguishes them from EC 3.1.3.56.
Cross-references
BRENDA3.1.3.36
EC2PDB3.1.3.36
ExplorEnz3.1.3.36
PRIAM enzyme-specific profiles3.1.3.36
KEGG Ligand Database for Enzyme Nomenclature3.1.3.36
IUBMB Enzyme Nomenclature3.1.3.36
IntEnz3.1.3.36
MEDLINEFind literature relating to 3.1.3.36
MetaCyc3.1.3.36
Rhea expert-curated reactions3.1.3.36
UniProtKB/Swiss-Prot
Q92562, FIG4_HUMANQ91WF7, FIG4_MOUSEP32019, I5P2_HUMAN
Q8K337, I5P2_MOUSEP40559, INP51_YEASTP50942, INP52_YEAST
Q12271, INP53_YEASTQ08227, INP54_YEASTQ9VTW2, INP5E_DROME
Q9NRR6, INP5E_HUMANQ9JII1, INP5E_MOUSEA0FI79, INP5E_PANTR
Q9WVR1, INP5E_RATQ9BT40, INP5K_HUMANQ8C5L6, INP5K_MOUSE
Q8H0Z6, IP5P3_ARATHQ9LR47, IP5P6_ARATHQ0WQ41, IP5P7_ARATH
Q9SIS4, IP5P9_ARATHQ5EAF2, IP5PB_ARATHQ9SKB7, IP5PE_ARATH
Q84W55, IP5PF_ARATHQ01968, OCRL_HUMANQ6NVF0, OCRL_MOUSE
D3ZGS3, OCRL_RATQ15735, PI5PA_HUMANP59644, PI5PA_MOUSE
Q9JMC1, PI5PA_RATQ92835, SHIP1_HUMANQ9ES52, SHIP1_MOUSE
P97573, SHIP1_RATQ6P4S2, SHIP1_XENLAO43001, SYJ1_SCHPO
Q9USQ6, SYJ2_SCHPOO18964, SYNJ1_BOVINO43426, SYNJ1_HUMAN
Q8CHC4, SYNJ1_MOUSEQ62910, SYNJ1_RATO15056, SYNJ2_HUMAN
Q9D2G5, SYNJ2_MOUSEO55207, SYNJ2_RATG5ECL2, SYNJ_CAEEL

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.3.-
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