| Accepted Name |
|---|
| phosphoinositide 5-phosphatase.
|
| Alternative Name(s) |
|---|
| diphosphoinositide phosphatase. |
| inositol 1,4,5-triphosphate 5-phosphomonoesterase. |
| inositol triphosphate 5-phosphomonoesterase. |
| IP3 phosphatase. |
| phosphatidylinositol 4,5-bisphosphate phosphatase. |
| phosphatidylinositol-bisphosphatase. |
| phosphatidyl-inositol-bisphosphate phosphatase. |
| phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase. |
| polyphosphoinositol lipid 5-phosphatase. |
| PtdIns(4,5)P2 phosphatase. |
| triphosphoinositide phosphatase. |
| triphosphoinositide phosphomonoesterase. |
| type II inositol-1,4,5-trisphosphate 5-phosphatase. |
| type II inositol polyphosphate 5-phosphatase. |
| Reaction catalysed |
|---|
| a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate |
| Comment(s) |
|---|
- These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3
and/or Ins(1,3,4,5)P4.
- They are a diverse family of enzymes, with differing abilities to
catalyze two or more of the four reactions listed.
- They are thought to use inositol lipids rather than inositol
phosphates as substrates in vivo.
- All of them can use either or both of PtdIns(4,5)P2 and
PtdIns(3,4,5)P3 as substrates; this is the main property that
distinguishes them from EC 3.1.3.56.
|
| Cross-references |
|---|
| BRENDA | 3.1.3.36 |
| EC2PDB | 3.1.3.36 |
| ExplorEnz | 3.1.3.36 |
| PRIAM enzyme-specific profiles | 3.1.3.36 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.1.3.36 |
| IUBMB Enzyme Nomenclature | 3.1.3.36 |
| IntEnz | 3.1.3.36 |
| MEDLINE | Find literature relating to 3.1.3.36 |
| MetaCyc | 3.1.3.36 |
| Rhea expert-curated reactions | 3.1.3.36 |
| UniProtKB/Swiss-Prot |
| Q92562, FIG4_HUMAN; | Q91WF7, FIG4_MOUSE; | P32019, I5P2_HUMAN; |
| Q8K337, I5P2_MOUSE; | P40559, INP51_YEAST; | P50942, INP52_YEAST; |
| Q12271, INP53_YEAST; | Q08227, INP54_YEAST; | Q9VTW2, INP5E_DROME; |
| Q9NRR6, INP5E_HUMAN; | Q9JII1, INP5E_MOUSE; | A0FI79, INP5E_PANTR; |
| Q9WVR1, INP5E_RAT; | Q9BT40, INP5K_HUMAN; | Q8C5L6, INP5K_MOUSE; |
| Q8H0Z6, IP5P3_ARATH; | Q9LR47, IP5P6_ARATH; | Q0WQ41, IP5P7_ARATH; |
| Q9SIS4, IP5P9_ARATH; | Q5EAF2, IP5PB_ARATH; | Q9SKB7, IP5PE_ARATH; |
| Q84W55, IP5PF_ARATH; | Q01968, OCRL_HUMAN; | Q6NVF0, OCRL_MOUSE; |
| D3ZGS3, OCRL_RAT; | Q92835, SHIP1_HUMAN; | Q9ES52, SHIP1_MOUSE; |
| P97573, SHIP1_RAT; | Q6P4S2, SHIP1_XENLA; | O43001, SYJ1_SCHPO; |
| Q9USQ6, SYJ2_SCHPO; | O18964, SYNJ1_BOVIN; | O43426, SYNJ1_HUMAN; |
| Q8CHC4, SYNJ1_MOUSE; | Q62910, SYNJ1_RAT; | O15056, SYNJ2_HUMAN; |
| Q9D2G5, SYNJ2_MOUSE; | O55207, SYNJ2_RAT; | G5ECL2, SYNJ_CAEEL; |
|