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ENZYME entry: EC 3.1.3.81

Accepted Name
Diacylglycerol diphosphate phosphatase.
Alternative Name(s)
DGPP phosphatase.
DGPP phosphohydrolase.
Pyrophosphate phosphatase.
Reaction catalysed
1,2-diacyl-sn-glycerol 3-diphosphate + H(2)O <=> 1,2-diacyl-sn-glycerol 3-phosphate + phosphate
Comment(s)
  • The bifunctional enzyme catalyzes the dephosphorylation of diacylglycerol diphosphate to phosphatidate and the subsequent dephosphorylation of phosphatidate to diacylglycerol (cf. EC 3.1.3.4).
  • It regulates intracellular levels of diacylglycerol diphosphate and phosphatidate, phospholipid molecules believed to play a signaling role in stress response.
  • The phosphatase activity of the bifunctional enzyme is Mg(2+)- independent and N-ethylmaleimide-insensitive and is distinct from the Mg(2+)-dependent and N-ethylmaleimide-sensitive enzyme EC 3.1.3.4.
  • The diacylglycerol pyrophosphate phosphatase activity in Saccharomyces cerevisiae is induced by zinc depletion, by inositol supplementation, and when cells enter the stationary phase.
Cross-references
BRENDA3.1.3.81
EC2PDB3.1.3.81
ExplorEnz3.1.3.81
PRIAM enzyme-specific profiles3.1.3.81
KEGG Ligand Database for Enzyme Nomenclature3.1.3.81
IUBMB Enzyme Nomenclature3.1.3.81
IntEnz3.1.3.81
MEDLINEFind literature relating to 3.1.3.81
MetaCyc3.1.3.81
Rhea expert-curated reactions3.1.3.81
UniProtKB/Swiss-Prot
Q9UUA6, DPP1_SCHPO;  Q05521, DPP1_YEAST;  Q04396, LPP1_YEAST;  
P0A925, PGPB_ECO57;  P0A924, PGPB_ECOLI;  P44570, PGPB_HAEIN;  
P0A926, PGPB_SHIFL;  O88956, PLPP1_CAVPO;  O14494, PLPP1_HUMAN;  
Q61469, PLPP1_MOUSE;  P60588, PLPP1_PIG;  O08564, PLPP1_RAT;  
Q5VZY2, PLPP4_HUMAN;  Q0VBU9, PLPP4_MOUSE;  Q8NEB5, PLPP5_HUMAN;  
Q3UMZ3, PLPP5_MOUSE;  Q6GQ62, PLPP5_XENLA;  

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