ENZYME

ENZYME entry: EC 3.1.3.81

Accepted Name

Diacylglycerol diphosphate phosphatase.

Alternative Name(s)

DGPP phosphatase.

DGPP phosphohydrolase.

Pyrophosphate phosphatase.

Reaction catalysed

1,2-diacyl-sn-glycerol 3-diphosphate + H(2)O <=> 1,2-diacyl-sn-glycerol 3-phosphate + phosphate

Comment(s)

The bifunctional enzyme catalyzes the dephosphorylation of diacylglycerol diphosphate to phosphatidate and the subsequent dephosphorylation of phosphatidate to diacylglycerol (cf. EC 3.1.3.4).
It regulates intracellular levels of diacylglycerol diphosphate and phosphatidate, phospholipid molecules believed to play a signaling role in stress response.
The phosphatase activity of the bifunctional enzyme is Mg(2+)- independent and N-ethylmaleimide-insensitive and is distinct from the Mg(2+)-dependent and N-ethylmaleimide-sensitive enzyme EC 3.1.3.4.
The diacylglycerol pyrophosphate phosphatase activity in Saccharomyces cerevisiae is induced by zinc depletion, by inositol supplementation, and when cells enter the stationary phase.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature