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ENZYME entry: EC

Accepted Name
Diacylglycerol diphosphate phosphatase.
Alternative Name(s)
DGPP phosphatase.
DGPP phosphohydrolase.
Pyrophosphate phosphatase.
Reaction catalysed
1,2-diacyl-sn-glycerol 3-diphosphate + H(2)O <=> 1,2-diacyl-sn-glycerol 3-phosphate + phosphate
  • The bifunctional enzyme catalyzes the dephosphorylation of diacylglycerol diphosphate to phosphatidate and the subsequent dephosphorylation of phosphatidate to diacylglycerol (cf. EC
  • It regulates intracellular levels of diacylglycerol diphosphate and phosphatidate, phospholipid molecules believed to play a signaling role in stress response.
  • The phosphatase activity of the bifunctional enzyme is Mg(2+)- independent and N-ethylmaleimide-insensitive and is distinct from the Mg(2+)-dependent and N-ethylmaleimide-sensitive enzyme EC
  • The diacylglycerol pyrophosphate phosphatase activity in Saccharomyces cerevisiae is induced by zinc depletion, by inositol supplementation, and when cells enter the stationary phase.
PRIAM enzyme-specific profiles3.1.3.81
KEGG Ligand Database for Enzyme Nomenclature3.1.3.81
IUBMB Enzyme Nomenclature3.1.3.81
MEDLINEFind literature relating to
Q9UUA6, DPP1_SCHPO;  Q05521, DPP1_YEAST;  Q04396, LPP1_YEAST;  
P0A925, PGPB_ECO57;  P0A924, PGPB_ECOLI;  P44570, PGPB_HAEIN;  

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