ENZYME entry: EC 3.1.3.81
Accepted Name |
Diacylglycerol diphosphate phosphatase.
|
Alternative Name(s) |
DGPP phosphatase. |
DGPP phosphohydrolase. |
Pyrophosphate phosphatase. |
Reaction catalysed |
1,2-diacyl-sn-glycerol 3-diphosphate + H(2)O <=> 1,2-diacyl-sn-glycerol 3-phosphate + phosphate |
Comment(s) |
- The bifunctional enzyme catalyzes the dephosphorylation of
diacylglycerol diphosphate to phosphatidate and the subsequent
dephosphorylation of phosphatidate to diacylglycerol (cf.
EC 3.1.3.4).
- It regulates intracellular levels of diacylglycerol diphosphate and
phosphatidate, phospholipid molecules believed to play a signaling
role in stress response.
- The phosphatase activity of the bifunctional enzyme is Mg(2+)-
independent and N-ethylmaleimide-insensitive and is distinct from the
Mg(2+)-dependent and N-ethylmaleimide-sensitive enzyme EC 3.1.3.4.
- The diacylglycerol pyrophosphate phosphatase activity in
Saccharomyces cerevisiae is induced by zinc depletion, by inositol
supplementation, and when cells enter the stationary phase.
|
Cross-references |
BRENDA | 3.1.3.81 |
EC2PDB | 3.1.3.81 |
ExplorEnz | 3.1.3.81 |
PRIAM enzyme-specific profiles | 3.1.3.81 |
KEGG Ligand Database for Enzyme Nomenclature | 3.1.3.81 |
IUBMB Enzyme Nomenclature | 3.1.3.81 |
IntEnz | 3.1.3.81 |
MEDLINE | Find literature relating to 3.1.3.81 |
MetaCyc | 3.1.3.81 |
UniProtKB/Swiss-Prot |
Q9UUA6, DPP1_SCHPO; | Q05521, DPP1_YEAST; | Q04396, LPP1_YEAST; |
P0A925, PGPB_ECO57; | P0A924, PGPB_ECOLI; | P44570, PGPB_HAEIN; |
P0A926, PGPB_SHIFL; | O88956, PLPP1_CAVPO; | O14494, PLPP1_HUMAN; |
Q61469, PLPP1_MOUSE; | P60588, PLPP1_PIG; | O08564, PLPP1_RAT; |
Q5VZY2, PLPP4_HUMAN; | Q0VBU9, PLPP4_MOUSE; | Q8NEB5, PLPP5_HUMAN; |
Q3UMZ3, PLPP5_MOUSE; | Q6GQ62, PLPP5_XENLA; |
|
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