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ENZYME

ENZYME entry: EC 3.6.1.75

PURL: https://purl.expasy.org/enzyme/EC/3.6.1.75
Accepted Name
diacylglycerol diphosphate phosphatase
Alternative Name(s)
DGPP phosphatase
DGPP phosphohydrolase
pyrophosphate phosphatase
Reaction catalysed
a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + phosphate + H(+)
Comment(s)
  • The bifunctional enzyme catalyzes the dephosphorylation of diacylglycerol diphosphate to phosphatidate and the subsequent dephosphorylation of phosphatidate to diacylglycerol (cf. EC 3.1.3.4).
  • It regulates intracellular levels of diacylglycerol diphosphate and phosphatidate, phospholipid molecules believed to play a signaling role in stress response.
  • The phosphatase activity of the bifunctional enzyme is Mg(2+)- independent and N-ethylmaleimide-insensitive and is distinct from the Mg(2+)-dependent and N-ethylmaleimide-sensitive enzyme EC 3.1.3.4.
  • The diacylglycerol pyrophosphate phosphatase activity in Saccharomyces cerevisiae is induced by zinc depletion, by inositol supplementation, and when cells enter the stationary phase.
  • Formerly EC 3.1.3.81.
Cross-references
BRENDA3.6.1.75
EC2PDB3.6.1.75
ExplorEnz3.6.1.75
KEGG Ligand Database for Enzyme Nomenclature3.6.1.75
IUBMB Enzyme Nomenclature3.6.1.75
MEDLINEFind literature relating to 3.6.1.75
MetaCyc3.6.1.75
Rhea expert-curated reactions3.6.1.75
UniProtKB/Swiss-Prot
Q9UUA6, DPP1_SCHPOQ05521, DPP1_YEASTQ04396, LPP1_YEAST
P0A925, PGPB_ECO57P0A924, PGPB_ECOLIP44570, PGPB_HAEIN
P0A926, PGPB_SHIFLO88956, PLPP1_CAVPOO14494, PLPP1_HUMAN
Q61469, PLPP1_MOUSEP60588, PLPP1_PIGO08564, PLPP1_RAT
Q5VZY2, PLPP4_HUMANQ0VBU9, PLPP4_MOUSEQ8NEB5, PLPP5_HUMAN
Q3UMZ3, PLPP5_MOUSEQ6GQ62, PLPP5_XENLA

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