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ENZYME

ENZYME entry: EC 3.1.4.11

PURL: https://purl.expasy.org/enzyme/EC/3.1.4.11
Accepted Name
phosphoinositide phospholipase C
Alternative Name(s)
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
monophosphatidylinositol phosphodiesterase
phosphatidylinositol phospholipase C
phosphoinositidase C
PI-PLC
triphosphoinositide phosphodiesterase
Reaction catalysed
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)
Comment(s)
  • These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P2 as well as Ins(1,4,5)P3.
  • They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.
Cross-references
BRENDA3.1.4.11
EC2PDB3.1.4.11
ExplorEnz3.1.4.11
KEGG Ligand Database for Enzyme Nomenclature3.1.4.11
IUBMB Enzyme Nomenclature3.1.4.11
MEDLINEFind literature relating to 3.1.4.11
MetaCyc3.1.4.11
Rhea expert-curated reactions3.1.4.11
UniProtKB/Swiss-Prot
Q3KTM2, GDPD5_CHICKQ8WTR4, GDPD5_HUMANQ640M6, GDPD5_MOUSE
P25455, PIP1_DROMEP13217, PIPA_DROMEO13433, PLC1_CANAX
P40977, PLC1_SCHPOP32383, PLC1_YEASTP10894, PLCB1_BOVIN
Q9NQ66, PLCB1_HUMANQ9Z1B3, PLCB1_MOUSEP10687, PLCB1_RAT
Q00722, PLCB2_HUMANA3KGF7, PLCB2_MOUSEO89040, PLCB2_RAT
Q01970, PLCB3_HUMANP51432, PLCB3_MOUSEQ99JE6, PLCB3_RAT
Q07722, PLCB4_BOVINQ15147, PLCB4_HUMANQ9QW07, PLCB4_RAT
G5EBH0, PLCB_CAEELQ39032, PLCD1_ARATHP10895, PLCD1_BOVIN
P51178, PLCD1_HUMANQ8R3B1, PLCD1_MOUSEP10688, PLCD1_RAT
Q39033, PLCD2_ARATHQ56W08, PLCD3_ARATHQ8N3E9, PLCD3_HUMAN
Q8K2J0, PLCD3_MOUSEQ944C1, PLCD4_ARATHP21671, PLCD4_BOVIN
Q9BRC7, PLCD4_HUMANQ4R6L3, PLCD4_MACFAQ8K3R3, PLCD4_MOUSE
Q8SPR7, PLCD4_PIGQ5RET0, PLCD4_PONABQ62711, PLCD4_RAT
Q32NH8, PLCD4_XENLAQ944C2, PLCD5_ARATHQ8GV43, PLCD6_ARATH
Q9LY51, PLCD7_ARATHQ9STZ3, PLCD8_ARATHQ6NMA7, PLCD9_ARATH
G5EFI8, PLCE1_CAEELQ9P212, PLCE1_HUMANQ8K4S1, PLCE1_MOUSE
Q99P84, PLCE1_RATP08487, PLCG1_BOVINP19174, PLCG1_HUMAN
Q62077, PLCG1_MOUSEP10686, PLCG1_RATP16885, PLCG2_HUMAN
Q8CIH5, PLCG2_MOUSEP24135, PLCG2_RATQ22070, PLCG_CAEEL
Q4KWH8, PLCH1_HUMANQ4KWH5, PLCH1_MOUSEO75038, PLCH2_HUMAN
A2AP18, PLCH2_MOUSEQ1RML2, PLCZ1_BOVINQ2VRL0, PLCZ1_CHICK
Q86YW0, PLCZ1_HUMANQ95JS1, PLCZ1_MACFAQ8K4D7, PLCZ1_MOUSE
Q7YRU3, PLCZ1_PIGQ5FX52, PLCZ1_RATQ02158, PLC_DICDI
A5D6R3, PLD3A_DANRE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-