ENZYME entry: EC 3.1.4.11

Accepted Name
Phosphoinositide phospholipase C.
Alternative Name(s)
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase.
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase.
Monophosphatidylinositol phosphodiesterase.
Phosphatidylinositol phospholipase C.
Phosphoinositidase C.
PI-PLC.
Triphosphoinositide phosphodiesterase.
Reaction catalysed
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O <=> 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Comment(s)
  • These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3).
  • They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.
Cross-references
BRENDA3.1.4.11
EC2PDB3.1.4.11
ExplorEnz3.1.4.11
PRIAM enzyme-specific profiles3.1.4.11
KEGG Ligand Database for Enzyme Nomenclature3.1.4.11
IUBMB Enzyme Nomenclature3.1.4.11
IntEnz3.1.4.11
MEDLINEFind literature relating to 3.1.4.11
MetaCyc3.1.4.11
UniProtKB/Swiss-Prot
P25455, PIP1_DROME;  P13217, PIPA_DROME;  O13433, PLC1_CANAX;  
P40977, PLC1_SCHPO;  P32383, PLC1_YEAST;  P10894, PLCB1_BOVIN;  
Q9NQ66, PLCB1_HUMAN;  Q9Z1B3, PLCB1_MOUSE;  P10687, PLCB1_RAT;  
Q00722, PLCB2_HUMAN;  A3KGF7, PLCB2_MOUSE;  O89040, PLCB2_RAT;  
Q01970, PLCB3_HUMAN;  P51432, PLCB3_MOUSE;  Q99JE6, PLCB3_RAT;  
Q07722, PLCB4_BOVIN;  Q15147, PLCB4_HUMAN;  Q9QW07, PLCB4_RAT;  
G5EBH0, PLCB_CAEEL;  Q39032, PLCD1_ARATH;  P10895, PLCD1_BOVIN;  
P51178, PLCD1_HUMAN;  Q8R3B1, PLCD1_MOUSE;  P10688, PLCD1_RAT;  
Q39033, PLCD2_ARATH;  Q56W08, PLCD3_ARATH;  Q8N3E9, PLCD3_HUMAN;  
Q8K2J0, PLCD3_MOUSE;  Q944C1, PLCD4_ARATH;  P21671, PLCD4_BOVIN;  
Q9BRC7, PLCD4_HUMAN;  Q4R6L3, PLCD4_MACFA;  Q8K3R3, PLCD4_MOUSE;  
Q8SPR7, PLCD4_PIG;  Q5RET0, PLCD4_PONAB;  Q62711, PLCD4_RAT;  
Q32NH8, PLCD4_XENLA;  Q944C2, PLCD5_ARATH;  Q8GV43, PLCD6_ARATH;  
Q9LY51, PLCD7_ARATH;  Q9STZ3, PLCD8_ARATH;  Q6NMA7, PLCD9_ARATH;  
G5EFI8, PLCE1_CAEEL;  Q9P212, PLCE1_HUMAN;  Q8K4S1, PLCE1_MOUSE;  
Q99P84, PLCE1_RAT;  P08487, PLCG1_BOVIN;  P19174, PLCG1_HUMAN;  
Q62077, PLCG1_MOUSE;  P10686, PLCG1_RAT;  P16885, PLCG2_HUMAN;  
Q8CIH5, PLCG2_MOUSE;  P24135, PLCG2_RAT;  Q22070, PLCG_CAEEL;  
Q4KWH8, PLCH1_HUMAN;  Q4KWH5, PLCH1_MOUSE;  O75038, PLCH2_HUMAN;  
A2AP18, PLCH2_MOUSE;  Q1RML2, PLCZ1_BOVIN;  Q2VRL0, PLCZ1_CHICK;  
Q86YW0, PLCZ1_HUMAN;  Q95JS1, PLCZ1_MACFA;  Q8K4D7, PLCZ1_MOUSE;  
Q7YRU3, PLCZ1_PIG;  Q5FX52, PLCZ1_RAT;  Q02158, PLC_DICDI;  
A5D6R3, PLD3A_DANRE;  

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