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ENZYME entry: EC 3.1.4.45

Accepted Name
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase.
Alternative Name(s)
alpha-N-acetylglucosaminyl phosphodiesterase.
lysosomal alpha-N-acetylglucosaminidase.
Reaction catalysed
H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] <=> H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine
Comment(s)
Acts on a variety of compounds in which N-acetyl-D-glucosamine is alpha-linked to a phosphate group, including the biosynthetic in intermediates of the high mannose oligosaccharide components of some lysosomal enzymes and the product of EC 2.7.8.17.
Cross-references
BRENDA3.1.4.45
EC2PDB3.1.4.45
ExplorEnz3.1.4.45
PRIAM enzyme-specific profiles3.1.4.45
KEGG Ligand Database for Enzyme Nomenclature3.1.4.45
IUBMB Enzyme Nomenclature3.1.4.45
IntEnz3.1.4.45
MEDLINEFind literature relating to 3.1.4.45
MetaCyc3.1.4.45
Rhea expert-curated reactions3.1.4.45
UniProtKB/Swiss-Prot
P68827, NAGPA_BOVIN;  Q9UK23, NAGPA_HUMAN;  Q8BJ48, NAGPA_MOUSE;  

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