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ENZYME entry: EC 3.1.4.59

Accepted Name
cyclic-di-AMP phosphodiesterase.
Reaction catalysed
3',3'-c-di-AMP + H2O <=> 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)
Comment(s)
  • The enzyme, described from Gram-positive bacteria, degrades the second messenger cyclic di-3',5'-adenylate.
  • It is a membrane-bound protein that contains a cytoplasmic facing Per-Arnt-Sim (PAS) domain, a modified GGDEF domain, and a DHH/DHHA1 domain, which confers the phosphodiesterase activity.
  • Activity requires Mn(2+) and is inhibited by pApA.
Cross-references
BRENDA3.1.4.59
EC2PDB3.1.4.59
ExplorEnz3.1.4.59
PRIAM enzyme-specific profiles3.1.4.59
KEGG Ligand Database for Enzyme Nomenclature3.1.4.59
IUBMB Enzyme Nomenclature3.1.4.59
IntEnz3.1.4.59
MEDLINEFind literature relating to 3.1.4.59
MetaCyc3.1.4.59
Rhea expert-curated reactions3.1.4.59
UniProtKB/Swiss-Prot
P37484, GDPP_BACSU;  A4ITV2, GDPP_GEOTN;  A0A0H3GCG4, PDEA_LISM4;  
P46344, PGPH_BACSU;  A0A0H3GGY3, PGPH_LISM4;  

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