ENZYME entry: EC 3.1.4.59
Accepted Name |
Cyclic-di-AMP phosphodiesterase.
|
Reaction catalysed |
Cyclic di-3',5'-adenylate + H(2)O <=> 5'-O-phosphonoadenylyl-(3'->5')-adenosine |
Comment(s) |
- The enzyme, described from Gram-positive bacteria, degrades the
second messenger cyclic di-3',5'-adenylate.
- It is a membrane-bound protein that contains a cytoplasmic facing
Per-Arnt-Sim (PAS) domain, a modified GGDEF domain, and a DHH/DHHA1
domain, which confers the phosphodiesterase activity.
- Activity requires Mn(2+) and is inhibited by pApA.
|
Cross-references |
BRENDA | 3.1.4.59 |
EC2PDB | 3.1.4.59 |
ExplorEnz | 3.1.4.59 |
PRIAM enzyme-specific profiles | 3.1.4.59 |
KEGG Ligand Database for Enzyme Nomenclature | 3.1.4.59 |
IUBMB Enzyme Nomenclature | 3.1.4.59 |
IntEnz | 3.1.4.59 |
MEDLINE | Find literature relating to 3.1.4.59 |
MetaCyc | 3.1.4.59 |
Rhea expert-curated reactions | 3.1.4.59 |
UniProtKB/Swiss-Prot |
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