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ENZYME entry: EC 3.13.1.9

Accepted Name
S-inosyl-L-homocysteine hydrolase.
Reaction catalysed
S-inosyl-L-homocysteine + H(2)O <=> inosine + L-homocysteine
Comment(s)
  • The enzyme, characterized from the methanogenic archaeon Methanocaldococcus jannaschii, binds an NAD(+) cofactor.
  • It participates in an alternative pathway for the regeneration of S-adenosyl-L-methionine from S-adenosyl-L-homocysteine that involves the deamination of the latter to S-inosyl-L-homocysteine.
Cross-references
BRENDA3.13.1.9
EC2PDB3.13.1.9
ExplorEnz3.13.1.9
PRIAM enzyme-specific profiles3.13.1.9
KEGG Ligand Database for Enzyme Nomenclature3.13.1.9
IUBMB Enzyme Nomenclature3.13.1.9
IntEnz3.13.1.9
MEDLINEFind literature relating to 3.13.1.9
MetaCyc3.13.1.9
Rhea expert-curated reactions3.13.1.9
UniProtKB/Swiss-Prot
Q8TRA5, SIHH_METAC;  Q58783, SIHH_METJA;  P58855, SIHH_METKA;  
Q8PUQ4, SIHH_METMA;  Q6LYR8, SIHH_METMP;  O27673, SIHH_METTH;  

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