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ENZYME

ENZYME entry: EC 3.13.1.9

PURL: https://purl.expasy.org/enzyme/EC/3.13.1.9
Accepted Name
S-inosyl-L-homocysteine hydrolase
Reaction catalysed
S-inosyl-L-homocysteine + H2O = L-homocysteine + inosine
Comment(s)
  • The enzyme, characterized from the methanogenic archaeon Methanocaldococcus jannaschii, binds an NAD(+) cofactor.
  • It participates in an alternative pathway for the regeneration of S-adenosyl-L-methionine from S-adenosyl-L-homocysteine that involves the deamination of the latter to S-inosyl-L-homocysteine.
Cross-references
BRENDA3.13.1.9
EC2PDB3.13.1.9
ExplorEnz3.13.1.9
KEGG Ligand Database for Enzyme Nomenclature3.13.1.9
IUBMB Enzyme Nomenclature3.13.1.9
MEDLINEFind literature relating to 3.13.1.9
MetaCyc3.13.1.9
Rhea expert-curated reactions3.13.1.9
UniProtKB/Swiss-Prot
Q8TRA5, SIHH_METACQ58783, SIHH_METJAP58855, SIHH_METKA
Q8PUQ4, SIHH_METMAQ6LYR8, SIHH_METMPO27673, SIHH_METTH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.13.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.13.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-