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ENZYME

ENZYME entry: EC 3.13.2.1

Accepted Name
adenosylhomocysteinase
Alternative Name(s)
adenosylhomocysteine hydrolase
AdoHcyase
S-adenosylhomocysteinase
S-adenosylhomocysteine hydrolase
S-adenosylhomocysteine synthase
SAHase
Reaction catalysed
H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine
Comment(s)
  • The enzyme contains one tightly bound NAD(+) per subunit.
  • This appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond, cf. EC 5.5.1.4.
  • Formerly EC 3.3.1.1.
Cross-references
BRENDA3.13.2.1
EC2PDB3.13.2.1
ExplorEnz3.13.2.1
PRIAM enzyme-specific profiles3.13.2.1
KEGG Ligand Database for Enzyme Nomenclature3.13.2.1
IUBMB Enzyme Nomenclature3.13.2.1
IntEnz3.13.2.1
MEDLINEFind literature relating to 3.13.2.1
MetaCyc3.13.2.1
Rhea expert-curated reactions3.13.2.1
UniProtKB/Swiss-Prot
O23255, SAHH1_ARATHP84533, SAHH1_POPEUQ9LK36, SAHH2_ARATH
P84532, SAHH2_POPEUA6QLP2, SAHH3_BOVINQ96HN2, SAHH3_HUMAN
Q68FL4, SAHH3_MOUSEQ5R889, SAHH3_PONABP51893, SAHHA_XENLA
O93477, SAHHB_XENLAQ6FA43, SAHH_ACIADB9MD45, SAHH_ACIET
A1W3P0, SAHH_ACISJQ9YEF2, SAHH_AERPEQ8UJ99, SAHH_AGRFC
O76757, SAHH_ANOGAO67240, SAHH_AQUAEO28279, SAHH_ARCFU
Q5P6B7, SAHH_AROAEQ64MT2, SAHH_BACFRQ8A407, SAHH_BACTN
Q6G584, SAHH_BARHEQ6G1D6, SAHH_BARQUA9IL83, SAHH_BART1
Q6MNC0, SAHH_BDEBAQ7WQX5, SAHH_BORBRQ7W1Z7, SAHH_BORPA
A9IGY5, SAHH_BORPDQ7VUL8, SAHH_BORPEQ3MHL4, SAHH_BOVIN
Q89HP6, SAHH_BRADUA0A087WNH6, SAHH_BRAELA5ENA7, SAHH_BRASB
B2S994, SAHH_BRUA1Q2YQX8, SAHH_BRUA2A6WX40, SAHH_BRUA4
Q57AG3, SAHH_BRUABA9M9T1, SAHH_BRUC2C0RFY3, SAHH_BRUMB
Q8YE49, SAHH_BRUMEA5VT52, SAHH_BRUO2B0CJJ7, SAHH_BRUSI
Q8FXZ7, SAHH_BRUSUA3MQW7, SAHH_BURM7A2S6W2, SAHH_BURM9
Q62G22, SAHH_BURMAA1V8Z2, SAHH_BURMSA3P0L8, SAHH_BURP0
Q3JY79, SAHH_BURP1A3NER1, SAHH_BURP6Q63PT2, SAHH_BURPS
Q2STU0, SAHH_BURTAP27604, SAHH_CAEELP83783, SAHH_CANAL
P35007, SAHH_CATROQ9ABH0, SAHH_CAUVCO50562, SAHH_CERSP
Q11CD0, SAHH_CHESBQ3AQC2, SAHH_CHLCHB3EDY3, SAHH_CHLL2
Q3B532, SAHH_CHLL3B3QMF5, SAHH_CHLP8A1BEZ2, SAHH_CHLPD
A4SF77, SAHH_CHLPMQ8KEG8, SAHH_CHLTEA0M5W6, SAHH_CHRFK
Q7NZF7, SAHH_CHRVOP61456, SAHH_CORDIQ8FRJ4, SAHH_COREF
A4QC87, SAHH_CORGBQ8NSC4, SAHH_CORGLB6J6H1, SAHH_COXB1
B6J3R0, SAHH_COXB2A9KD88, SAHH_COXBNQ83A77, SAHH_COXBU
Q1LS20, SAHH_CUPMCQ0KF25, SAHH_CUPNHQ476T8, SAHH_CUPPJ
B2AGG2, SAHH_CUPTRA9C184, SAHH_DELASP10819, SAHH_DICDI
Q27580, SAHH_DROMEA5FJK3, SAHH_FLAJ1A6GW32, SAHH_FLAPJ
P61617, SAHH_GEOSLB7K8X6, SAHH_GLOC7Q7NGI6, SAHH_GLOVI
Q0BW40, SAHH_GRABCQ2SLT4, SAHH_HAHCHA1WXM7, SAHH_HALHL
B0R7F2, SAHH_HALS3Q9HN50, SAHH_HALSAG0LFB0, SAHH_HALWC
Q18EV6, SAHH_HALWDA4G975, SAHH_HERARP23526, SAHH_HUMAN
Q0C427, SAHH_HYPNAA6T2Y9, SAHH_JANMAP36889, SAHH_LEIDO
Q04NN6, SAHH_LEPBJQ04WX0, SAHH_LEPBLB1Y647, SAHH_LEPCP
Q75FU8, SAHH_LEPICQ8EXV1, SAHH_LEPINQ9SP37, SAHH_LUPLU
Q4R596, SAHH_MACFAQ0ALW1, SAHH_MARMMC6C1F4, SAHH_MARSD
P50246, SAHH_MEDSAP93253, SAHH_MESCRB7KSJ4, SAHH_METC4
Q60CG8, SAHH_METCAA9VYP7, SAHH_METEPB8IPU4, SAHH_METNO
B1ZLX0, SAHH_METPBA2SL00, SAHH_METPPB0UM37, SAHH_METS4
P50247, SAHH_MOUSEQ7TWW7, SAHH_MYCBOA1KNQ0, SAHH_MYCBP
C1AH22, SAHH_MYCBTB8ZQE9, SAHH_MYCLBQ9CCJ4, SAHH_MYCLE
B2HEP6, SAHH_MYCMMQ73UK6, SAHH_MYCPAA4ZHR8, SAHH_MYCS2
A3PW97, SAHH_MYCSJA1UCK8, SAHH_MYCSKQ1BCD6, SAHH_MYCSS
A5U7S2, SAHH_MYCTAP9WGV2, SAHH_MYCTOP9WGV3, SAHH_MYCTU
A0PRF5, SAHH_MYCUAQ1CY84, SAHH_MYXXDP68172, SAHH_NICSY
Q0AEV8, SAHH_NITECQ82WL1, SAHH_NITEUQ72EH1, SAHH_NITV2
A1VFZ7, SAHH_NITV4B8DR41, SAHH_NITV9Q5YQS7, SAHH_NOCFA
Q8YX05, SAHH_NOSS1Q2G6T1, SAHH_NOVADQ30WL8, SAHH_OLEA2
A1TUG3, SAHH_PARC0Q7U9Y3, SAHH_PARMWB2JIP4, SAHH_PARP8
B2T6X2, SAHH_PARPJQ13T36, SAHH_PARXLB4SD43, SAHH_PELPB
Q01781, SAHH_PETCRP50249, SAHH_PHASSQ710C4, SAHH_PIG
Q4XZZ5, SAHH_PLACUP50250, SAHH_PLAF7Q7RKK8, SAHH_PLAYO
Q12663, SAHH_PNECAA4T0E9, SAHH_POLAQB1XSH8, SAHH_POLNS
A3PFB5, SAHH_PROM0A8G7D1, SAHH_PROM2A2C620, SAHH_PROM3
A9BD69, SAHH_PROM4Q318B6, SAHH_PROM9Q7V9P3, SAHH_PROMA
Q7V926, SAHH_PROMMQ7UZN3, SAHH_PROMPQ48PB5, SAHH_PSE14
B7V419, SAHH_PSEA8Q02TY0, SAHH_PSEABQ9I685, SAHH_PSEAE
Q1I3W5, SAHH_PSEE4Q4K4H7, SAHH_PSEF5C3K3G6, SAHH_PSEFS
A4XPF3, SAHH_PSEMYA5WA09, SAHH_PSEP1Q3K5D7, SAHH_PSEPF
B0KM00, SAHH_PSEPGB1J2Y8, SAHH_PSEPWQ87V73, SAHH_PSESM
Q4ZZ92, SAHH_PSEU2Q9UYK5, SAHH_PYRABQ8ZTQ7, SAHH_PYRAE
P50251, SAHH_PYRFUO58275, SAHH_PYRHOQ8Y387, SAHH_RALN1
B2U774, SAHH_RALPJP10760, SAHH_RATB3PVW2, SAHH_RHIE6
Q2KE72, SAHH_RHIECQ1MNC6, SAHH_RHIJ3Q98CM3, SAHH_RHILO
B5ZV80, SAHH_RHILWQ92TC1, SAHH_RHIMEB9JG53, SAHH_RHIR8
Q7TTZ5, SAHH_RHOBAP28183, SAHH_RHOCBQ2IZR1, SAHH_RHOP2
Q6N2N5, SAHH_RHOPAQ13AQ5, SAHH_RHOPSB3QJT3, SAHH_RHOPT
Q9ZNA5, SAHH_ROSDOP50252, SAHH_SACS2O13639, SAHH_SCHPO
A6UEJ1, SAHH_SINMWQ9SWF5, SAHH_SOLLCQ01VU1, SAHH_SOLUE
Q1GWT5, SAHH_SPHALQ936D6, SAHH_STRAAQ82DC9, SAHH_STRAW
Q8GGL7, SAHH_STRAZQ9KZM1, SAHH_STRCOP26799, SAHH_STRFR
B1VUW6, SAHH_STRGGA4VRF7, SAHH_STUS1Q4JAZ7, SAHH_SULAC
Q975T0, SAHH_SULTOQ3A392, SAHH_SYNC1A5GI30, SAHH_SYNPW
Q0IDX7, SAHH_SYNS3Q3B0K7, SAHH_SYNS9Q3ANF4, SAHH_SYNSC
P74008, SAHH_SYNY3Q9HKX4, SAHH_THEACQ5JED2, SAHH_THEKO
O51933, SAHH_THEMAQ8DGC8, SAHH_THEVBQ979Z4, SAHH_THEVO
P68173, SAHH_TOBACP51540, SAHH_TRIVAC5CM29, SAHH_VARPS
P32112, SAHH_WHEATQ8PP84, SAHH_XANACQ4UQZ8, SAHH_XANC8
Q8PCH5, SAHH_XANCPQ3BXC6, SAHH_XANE5Q2NZE3, SAHH_XANOM
B2SPN6, SAHH_XANOPB2I7N4, SAHH_XYLF2Q9PEJ1, SAHH_XYLFA
B0U232, SAHH_XYLFMQ87EI8, SAHH_XYLFTP39954, SAHH_YEAST
Q5NR48, SAHH_ZYMMO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.13.2.-
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