ENZYME entry: EC 5.5.1.4

Accepted Name
Inositol-3-phosphate synthase.
Alternative Name(s)
1L-myo-inositol-1-phosphate lyase (isomerizing).
D-glucose 6-phosphate cycloaldolase.
Glucocycloaldolase.
Glucose 6-phosphate cyclase.
Inositol 1-phosphate synthetase.
Myo-inositol-1-phosphate synthase.
Reaction catalysed
D-glucose 6-phosphate <=> 1D-myo-inositol 3-phosphate
Cofactor(s)
NAD(+).
Comment(s)
The NAD(+) dehydrogenates the -CHOH- group to -CO- at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the -CHO at C-1; finally, the enzyme-bound NADH reconverts C-5 into the -CHOH- form.
Cross-references
BRENDA5.5.1.4
EC2PDB5.5.1.4
ExplorEnz5.5.1.4
PRIAM enzyme-specific profiles5.5.1.4
KEGG Ligand Database for Enzyme Nomenclature5.5.1.4
IUBMB Enzyme Nomenclature5.5.1.4
IntEnz5.5.1.4
MEDLINEFind literature relating to 5.5.1.4
MetaCyc5.5.1.4
UniProtKB/Swiss-Prot
Q7ZXY0, INO1A_XENLA;  Q6DDT1, INO1B_XENLA;  P42801, INO1_ARATH;  
Q2NL29, INO1_BOVIN;  Q96348, INO1_BRANA;  P42800, INO1_CANAL;  
Q6FQI1, INO1_CANGA;  P42802, INO1_CITPA;  Q54N49, INO1_DICDI;  
O97477, INO1_DROME;  O65195, INO1_HORVU;  Q9NPH2, INO1_HUMAN;  
Q4R6E3, INO1_MACFA;  Q9FPK7, INO1_MAIZE;  Q40271, INO1_MESCR;  
Q9JHU9, INO1_MOUSE;  A0R7G6, INO1_MYCS2;  P9WKI0, INO1_MYCTO;  
P9WKI1, INO1_MYCTU;  Q9SSV4, INO1_NICPA;  Q41107, INO1_PHAVU;  
Q6AYK3, INO1_RAT;  Q9FYV1, INO1_SESIN;  P42803, INO1_SPIPO;  
Q9LW96, INO1_TOBAC;  Q9S7U0, INO1_WHEAT;  P11986, INO1_YEAST;  
Q38862, INO2_ARATH;  Q9LX12, INO3_ARATH;  O64437, RINO1_ORYSJ;  
Q8S5N2, RINO2_ORYSJ;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.5.1.-
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