| Accepted Name |
|---|
| lanthipeptide synthase
|
| Reaction catalysed |
|---|
- a [protein]-L-serine + a [protein]-L-cysteine = a [protein] with lanthionine cross-link + H2O (overall reaction)
- a [protein]-L-threonine + a [protein]-L-cysteine = a [protein] with 3-methyllanthionine cross-link + H2O (overall reaction)
|
| Comment(s) |
|---|
- The lanthipeptides are a family of ribosomally synthesized and post-
translationally modified peptides (RiPPs) that is characterized by
the presence of multiple lanthionine (Lan) and 3-methyllanthionine
(MeLan) crosslinks, which are formed by lanthipeptide synthases.
- These enzymes catalyze dehydration of Ser/Thr residues, followed by
intramolecular addition of the thiol group of a Cys residue to the
dehydro amino acids, which results in the formation of the thioether
crosslinks of (methyl)lanthionine.
|
| Cross-references |
|---|
| BRENDA | 3.13.2.4 |
| EC2PDB | 3.13.2.4 |
| ExplorEnz | 3.13.2.4 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.13.2.4 |
| IUBMB Enzyme Nomenclature | 3.13.2.4 |
| MEDLINE | Find literature relating to 3.13.2.4 |
| MetaCyc | 3.13.2.4 |
| Rhea expert-curated reactions | 3.13.2.4 |
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