ENZYME entry: EC 3.2.1.130
| Accepted Name | ||||||
|---|---|---|---|---|---|---|
| glycoprotein endo-alpha-1,2-mannosidase | ||||||
| Alternative Name(s) | ||||||
| endo-alpha-D-mannosidase | ||||||
| Reaction catalysed | ||||||
| N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] + H2O = alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) | ||||||
| Comment(s) | ||||||
| The enzyme catalyzes the hydrolysis of the terminal alpha-D-glucosyl- (1->3)-D-mannosyl unit from the GlcMan9(GlcNAc)2 oligosaccharide component of N-glucosylated proteins during their processing in the Golgi apparatus. | ||||||
| Cross-references | ||||||
| Rhea expert-curated reactions | 3.2.1.130 | |||||
| ExplorEnz | 3.2.1.130 | |||||
| IUBMB Enzyme Nomenclature | 3.2.1.130 | |||||
| UniProtKB/Swiss-Prot |
| |||||
| BRENDA | 3.2.1.130 | |||||
| MetaCyc | 3.2.1.130 | |||||
| KEGG Ligand Database for Enzyme Nomenclature | 3.2.1.130 | |||||
| EC2PDB | 3.2.1.130 | |||||
| MEDLINE | Find literature relating to 3.2.1.130 | |||||
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