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ENZYME entry: EC 3.2.1.130

Accepted Name
Glycoprotein endo-alpha-1,2-mannosidase.
Alternative Name(s)
Endo-alpha-D-mannosidase.
Reaction catalysed
GlcMan(9)GlcNAc(2)-[protein] + H(2)O <=> Man(8)GlcNAc(2)-[protein] (isomer 8A(1,2,3)B(1,2)) + alpha-D-glucosyl-(1->3)-alpha-D-mannopyranose
Comment(s)
The enzyme catalyzes the hydrolysis of the terminal alpha-D-glucosyl- (1->3)-D-mannosyl unit from the GlcMan(9)(GlcNAc)(2) oligosaccharide component of N-glucosylated proteins during their processing in the Golgi apparatus.
Cross-references
BRENDA3.2.1.130
EC2PDB3.2.1.130
ExplorEnz3.2.1.130
PRIAM enzyme-specific profiles3.2.1.130
KEGG Ligand Database for Enzyme Nomenclature3.2.1.130
IUBMB Enzyme Nomenclature3.2.1.130
IntEnz3.2.1.130
MEDLINEFind literature relating to 3.2.1.130
MetaCyc3.2.1.130
Rhea expert-curated reactions3.2.1.130
UniProtKB/Swiss-Prot
Q5SRI9, MANEA_HUMAN;  Q6NXH2, MANEA_MOUSE;  Q5RD93, MANEA_PONAB;  
Q5GF25, MANEA_RAT;  Q6DE40, MANEA_XENLA;  

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