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ENZYME entry: EC 3.2.1.130

Accepted Name
glycoprotein endo-alpha-1,2-mannosidase.
Alternative Name(s)
endo-alpha-D-mannosidase.
Reaction catalysed
H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] <=> alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)
Comment(s)
The enzyme catalyzes the hydrolysis of the terminal alpha-D-glucosyl- (1->3)-D-mannosyl unit from the GlcMan9(GlcNAc)2 oligosaccharide component of N-glucosylated proteins during their processing in the Golgi apparatus.
Cross-references
BRENDA3.2.1.130
EC2PDB3.2.1.130
ExplorEnz3.2.1.130
PRIAM enzyme-specific profiles3.2.1.130
KEGG Ligand Database for Enzyme Nomenclature3.2.1.130
IUBMB Enzyme Nomenclature3.2.1.130
IntEnz3.2.1.130
MEDLINEFind literature relating to 3.2.1.130
MetaCyc3.2.1.130
Rhea expert-curated reactions3.2.1.130
UniProtKB/Swiss-Prot
Q5SRI9, MANEA_HUMAN;  Q6NXH2, MANEA_MOUSE;  Q5RD93, MANEA_PONAB;  
Q5GF25, MANEA_RAT;  Q6DE40, MANEA_XENLA;  

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