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ENZYME

ENZYME entry: EC 3.2.1.176

PURL: https://purl.expasy.org/enzyme/EC/3.2.1.176
Accepted Name
cellulose 1,4-beta-cellobiosidase (reducing end)
Alternative Name(s)
cellulase SS
endoglucanase SS
Reaction catalysed
Hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and similar substrates, releasing cellobiose from the reducing ends of the chains
Comment(s)
  • Some exocellulases, most of which belong to the glycoside hydrolase family 48 (GH48), act at the reducing ends of cellulose and similar substrates.
  • The CelS enzyme from Clostridium thermocellum is the most abundant subunit of the cellulosome formed by the organism.
  • It liberates cellobiose units from the reducing end by hydrolysis of the glycosidic bond, employing an inverting reaction mechanism.
  • Different from EC 3.2.1.91, which attacks cellulose from the non- reducing end.
Cross-references
BRENDA3.2.1.176
EC2PDB3.2.1.176
ExplorEnz3.2.1.176
KEGG Ligand Database for Enzyme Nomenclature3.2.1.176
IUBMB Enzyme Nomenclature3.2.1.176
MEDLINEFind literature relating to 3.2.1.176
MetaCyc3.2.1.176
Rhea expert-curated reactions3.2.1.176
UniProtKB/Swiss-Prot
A3DH67, GUNS_ACET2P0C2S5, GUNS_ACETH

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