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ENZYME

ENZYME entry: EC 3.2.2.28

PURL: https://purl.expasy.org/enzyme/EC/3.2.2.28
Accepted Name
double-stranded uracil-DNA glycosylase
Alternative Name(s)
dsUDG
Reaction catalysed
Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil
Comment(s)
  • No activity on DNA containing a T/G mispair or single-stranded DNA containing either a site-specific uracil or 3,N(4)-ethenocytosine residue, significant role for double-stranded uracil-DNA glycosylase in mutation avoidance in non-dividing Escherichia coli.
  • Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms.
  • Uracil-DNA glycosylase (EC 3.2.2.27) and double-stranded uracil-DNA glycosylase (EC 3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolyzing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalyzing the removal of mis-incorporated uracil from DNA.
Cross-references
BRENDA3.2.2.28
EC2PDB3.2.2.28
ExplorEnz3.2.2.28
KEGG Ligand Database for Enzyme Nomenclature3.2.2.28
IUBMB Enzyme Nomenclature3.2.2.28
MEDLINEFind literature relating to 3.2.2.28
MetaCyc3.2.2.28
Rhea expert-curated reactions3.2.2.28
UniProtKB/Swiss-Prot
A8APW0, MUG_CITK8A7MJU3, MUG_CROS8A7ZRV0, MUG_ECO24
B7MB04, MUG_ECO45B7LH04, MUG_ECO55Q8XAN4, MUG_ECO57
B5YRA8, MUG_ECO5EB7NJT2, MUG_ECO7IB7N0L8, MUG_ECO81
B7LZL8, MUG_ECO8AC4ZQY5, MUG_ECOBWB1XG73, MUG_ECODH
A8A4M5, MUG_ECOHSA1AFY9, MUG_ECOK1Q0TD38, MUG_ECOL5
P0A9H2, MUG_ECOL6B1IRP8, MUG_ECOLCP0A9H1, MUG_ECOLI
B7ND57, MUG_ECOLUB6I441, MUG_ECOSEB1LF61, MUG_ECOSM
Q1R6R1, MUG_ECOUTA4WEK3, MUG_ENT38B7LQE3, MUG_ESCF3
A6TE50, MUG_KLEP7B5XU18, MUG_KLEV3Q6D9D7, MUG_PECAS
C6DKG5, MUG_PECCPB5F6A8, MUG_SALA4A9MPV1, MUG_SALAR
Q57JP7, MUG_SALCHB5FHU7, MUG_SALDCB5QZ48, MUG_SALEP
B5REH0, MUG_SALG2B4TI63, MUG_SALHSB4T682, MUG_SALNS
Q5PKX5, MUG_SALPAA9N5Z1, MUG_SALPBC0PYY5, MUG_SALPC
B5BG24, MUG_SALPKB4TVU6, MUG_SALSVQ8XFG2, MUG_SALTI
Q7CPR7, MUG_SALTYP43343, MUG_SERMAA8GJV5, MUG_SERP5
B2U1S3, MUG_SHIB3Q31WW5, MUG_SHIBSQ32BP9, MUG_SHIDS
Q0T0J4, MUG_SHIF8Q3YXH4, MUG_SHISSO59825, TDG_SCHPO

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-