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ENZYME entry: EC 3.2.2.31

Accepted Name
Adenine glycosylase.
Alternative Name(s)
A/G-specific adenine glycosylase.
Reaction catalysed
Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site
Comment(s)
  • The enzyme serves as a mismatch repair enzyme that works to correct 7,8-dihydro-8-oxoguanine:adenine mispairs that arise in DNA when error-prone synthesis occurs past 7,8-dihydro-8-oxoguanine (GO) lesions in DNA.
  • The enzyme excises the adenine of the mispair, producing an apurinic site sensitive to AP endonuclease activity.
  • After removing the undamaged adenine the enzyme remains bound to the site to prevent EC 3.2.2.23 (MutM) from removing the GO lesion, which could lead to a double strand break.
  • In vitro the enzyme is also active with adenine:guanine, adenine:cytosine, and adenine:7,8-dihydro-8-oxoadenine (AO) mispairs, removing the adenine in all cases.
Cross-references
BRENDA3.2.2.31
EC2PDB3.2.2.31
ExplorEnz3.2.2.31
PRIAM enzyme-specific profiles3.2.2.31
KEGG Ligand Database for Enzyme Nomenclature3.2.2.31
IUBMB Enzyme Nomenclature3.2.2.31
IntEnz3.2.2.31
MEDLINEFind literature relating to 3.2.2.31
MetaCyc3.2.2.31
UniProtKB/Swiss-Prot
F4JRF4, MUTYH_ARATH;  Q9UIF7, MUTYH_HUMAN;  Q99P21, MUTYH_MOUSE;  
Q8R5G2, MUTYH_RAT;  P46230, MUTY_AERHY;  O31584, MUTY_BACSU;  
P57617, MUTY_BUCAI;  Q8K926, MUTY_BUCAP;  Q89A45, MUTY_BUCBP;  
P17802, MUTY_ECOLI;  P83847, MUTY_GEOSE;  P44320, MUTY_HAEIN;  
A0R567, MUTY_MYCS2;  P9WQ08, MUTY_MYCTO;  P9WQ09, MUTY_MYCTU;  
Q05869, MUTY_SALTY;  Q10159, MYH1_SCHPO;  

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