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ENZYME

ENZYME entry: EC 3.2.2.31

PURL: https://purl.expasy.org/enzyme/EC/3.2.2.31
Accepted Name
adenine glycosylase
Alternative Name(s)
A/G-specific adenine glycosylase
Reaction catalysed
Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site
Comment(s)
  • The enzyme serves as a mismatch repair enzyme that works to correct 7,8-dihydro-8-oxoguanine:adenine mispairs that arise in DNA when error-prone synthesis occurs past 7,8-dihydro-8-oxoguanine (GO) lesions in DNA.
  • The enzyme excises the adenine of the mispair, producing an apurinic site sensitive to AP endonuclease activity.
  • After removing the undamaged adenine the enzyme remains bound to the site to prevent EC 3.2.2.23 (MutM) from removing the GO lesion, which could lead to a double strand break.
  • In vitro the enzyme is also active with adenine:guanine, adenine:cytosine, and adenine:7,8-dihydro-8-oxoadenine (AO) mispairs, removing the adenine in all cases.
Cross-references
BRENDA3.2.2.31
EC2PDB3.2.2.31
ExplorEnz3.2.2.31
KEGG Ligand Database for Enzyme Nomenclature3.2.2.31
IUBMB Enzyme Nomenclature3.2.2.31
MEDLINEFind literature relating to 3.2.2.31
MetaCyc3.2.2.31
Rhea expert-curated reactions3.2.2.31
UniProtKB/Swiss-Prot
F4JRF4, MUTYH_ARATHQ9UIF7, MUTYH_HUMANQ99P21, MUTYH_MOUSE
Q8R5G2, MUTYH_RATP46230, MUTY_AERHYO31584, MUTY_BACSU
P57617, MUTY_BUCAIQ8K926, MUTY_BUCAPQ89A45, MUTY_BUCBP
P17802, MUTY_ECOLIP83847, MUTY_GEOSEP44320, MUTY_HAEIN
A0R567, MUTY_MYCS2P9WQ08, MUTY_MYCTOP9WQ09, MUTY_MYCTU
Q05869, MUTY_SALTYQ10159, MYH1_SCHPO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
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