ENZYME entry: EC 18.104.22.168
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|A/G-specific adenine glycosylase.|
|Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site|
- The enzyme serves as a mismatch repair enzyme that works to correct
7,8-dihydro-8-oxoguanine:adenine mispairs that arise in DNA when
error-prone synthesis occurs past 7,8-dihydro-8-oxoguanine (GO)
lesions in DNA.
- The enzyme excises the adenine of the mispair, producing an apurinic
site sensitive to AP endonuclease activity.
- After removing the undamaged adenine the enzyme remains bound to the
site to prevent EC 22.214.171.124 (MutM) from removing the GO lesion, which
could lead to a double strand break.
- In vitro the enzyme is also active with adenine:guanine,
adenine:cytosine, and adenine:7,8-dihydro-8-oxoadenine (AO) mispairs,
removing the adenine in all cases.
|PRIAM enzyme-specific profiles||126.96.36.199|
|KEGG Ligand Database for Enzyme Nomenclature||188.8.131.52|
|IUBMB Enzyme Nomenclature||184.108.40.206|
|MEDLINE||Find literature relating to 220.127.116.11|
|F4JRF4, MUTYH_ARATH; ||Q9UIF7, MUTYH_HUMAN; ||Q99P21, MUTYH_MOUSE; |
|Q8R5G2, MUTYH_RAT; ||P46230, MUTY_AERHY; ||O31584, MUTY_BACSU; |
|P57617, MUTY_BUCAI; ||Q8K926, MUTY_BUCAP; ||Q89A45, MUTY_BUCBP; |
|P17802, MUTY_ECOLI; ||P83847, MUTY_GEOSE; ||P44320, MUTY_HAEIN; |
|A0R567, MUTY_MYCS2; ||P9WQ08, MUTY_MYCTO; ||P9WQ09, MUTY_MYCTU; |
|Q05869, MUTY_SALTY; ||Q10159, MYH1_SCHPO; |
entries corresponding to 3.2.2.-
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