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ENZYME

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ENZYME entry: EC 3.3.2.7

Accepted Name
hepoxilin-epoxide hydrolase
Alternative Name(s)
hepoxilin A3 hydrolase
hepoxilin epoxide hydrolase
hepoxylin hydrolase
Reaction catalysed
(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate
Comment(s)
  • Converts hepoxilin A3 into trioxilin A3.
  • Highly specific for the substrate, having only slight activity with other epoxides such as leukotriene A4 and styrene oxide.
  • Probably plays a modulatory role in inflammation, vascular physiology, systemic glucose metabolism and neurological function.
Cross-references
BRENDA3.3.2.7
EC2PDB3.3.2.7
ExplorEnz3.3.2.7
PRIAM enzyme-specific profiles3.3.2.7
KEGG Ligand Database for Enzyme Nomenclature3.3.2.7
IUBMB Enzyme Nomenclature3.3.2.7
IntEnz3.3.2.7
MEDLINEFind literature relating to 3.3.2.7
MetaCyc3.3.2.7
Rhea expert-curated reactions3.3.2.7

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-