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ENZYME

ENZYME entry: EC 3.4.13.23

PURL: https://purl.expasy.org/enzyme/EC/3.4.13.23
Accepted Name
cysteinylglycine-S-conjugate dipeptidase
Reaction catalysed
an S-substituted L-cysteinylglycine + H2O = an S-substituted L-cysteine + glycine
Comment(s)
  • The enzyme participates in a widespread glutathione-mediated detoxification pathway.
  • In animals the activity is usually catalyzed by enzymes that have numerous additional activities, such as EC 3.4.11.1, EC 3.4.11.2 and EC 3.4.13.19.
  • However, in the bacterium Corynebacterium sp.Ax20, which degrades axillary secretions, the enzyme appears to be specific for this task.
Cross-references
BRENDA3.4.13.23
EC2PDB3.4.13.23
ExplorEnz3.4.13.23
KEGG Ligand Database for Enzyme Nomenclature3.4.13.23
IUBMB Enzyme Nomenclature3.4.13.23
MEDLINEFind literature relating to 3.4.13.23
MetaCyc3.4.13.23
Rhea expert-curated reactions3.4.13.23
UniProtKB/Swiss-Prot
P00727, AMPL_BOVINP28838, AMPL_HUMANP86249, AMPL_MESAU
Q9CPY7, AMPL_MOUSEP28839, AMPL_PIGQ68FS4, AMPL_RAT
Q5XGB9, AMPL_XENTRB2KZE7, TPDA_CORST

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