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ENZYME entry: EC 3.4.13.23

Accepted Name
Cysteinylglycine-S-conjugate dipeptidase.
Reaction catalysed
An (L-cysteinylglycine)-S-conjugate + H(2)O <=> an L-cysteine-S-conjugate + glycine
Comment(s)
  • The enzyme participates in a widespread glutathione-mediated detoxification pathway.
  • In animals the activity is usually catalyzed by enzymes that have numerous additional activities, such as EC 3.4.11.1, EC 3.4.11.2 and EC 3.4.13.19.
  • However, in the bacterium Corynebacterium sp.Ax20, which degrades axillary secretions, the enzyme appears to be specific for this task.
Cross-references
BRENDA3.4.13.23
EC2PDB3.4.13.23
ExplorEnz3.4.13.23
PRIAM enzyme-specific profiles3.4.13.23
KEGG Ligand Database for Enzyme Nomenclature3.4.13.23
IUBMB Enzyme Nomenclature3.4.13.23
IntEnz3.4.13.23
MEDLINEFind literature relating to 3.4.13.23
MetaCyc3.4.13.23
Rhea expert-curated reactions3.4.13.23
UniProtKB/Swiss-Prot
P00727, AMPL_BOVIN;  P28838, AMPL_HUMAN;  P86249, AMPL_MESAU;  
Q9CPY7, AMPL_MOUSE;  P28839, AMPL_PIG;  Q68FS4, AMPL_RAT;  
Q5XGB9, AMPL_XENTR;  B2KZE7, TPDA_CORST;  

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