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ENZYME entry: EC

Accepted Name
peptidyl-dipeptidase B
Alternative Name(s)
atrial di-(tri-)peptidyl carboxylase
atriopeptin convertase
dipeptidyl carboxyhydrolase
Reaction catalysed
Release of a C-terminal dipeptide or exceptionally a tripeptide
  • A membrane-bound, zinc metallopeptidase located in mammalian atrial, but not ventricular, myocytes.
  • Although it is capable of converting the 126-residue atriopeptin III directly to atriopeptin I by releasing a C-terminal tripeptide Phe- Arg-Tyr, it is generally restricted to the release of dipeptides.
  • In contrast to EC it displays no chlorine dependence and shows no action on angiotensin I.
  • Conversely, peptidyl-dipeptidase a is unable to release Phe-Arg from the C-terminus of atriopeptin II.
PRIAM enzyme-specific profiles3.4.15.4
KEGG Ligand Database for Enzyme Nomenclature3.4.15.4
IUBMB Enzyme Nomenclature3.4.15.4
MEDLINEFind literature relating to
Rhea expert-curated reactions3.4.15.4

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