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ENZYME

ENZYME entry: EC 3.4.15.4

PURL: https://purl.expasy.org/enzyme/EC/3.4.15.4
Accepted Name
peptidyl-dipeptidase B
Alternative Name(s)
atrial di-(tri-)peptidyl carboxylase
atriopeptin convertase
dipeptidyl carboxyhydrolase
Reaction catalysed
Release of a C-terminal dipeptide or exceptionally a tripeptide
Comment(s)
  • A membrane-bound, zinc metallopeptidase located in mammalian atrial, but not ventricular, myocytes.
  • Although it is capable of converting the 126-residue atriopeptin III directly to atriopeptin I by releasing a C-terminal tripeptide Phe- Arg-Tyr, it is generally restricted to the release of dipeptides.
  • In contrast to EC 3.4.15.1 it displays no chlorine dependence and shows no action on angiotensin I.
  • Conversely, peptidyl-dipeptidase a is unable to release Phe-Arg from the C-terminus of atriopeptin II.
Cross-references
BRENDA3.4.15.4
EC2PDB3.4.15.4
ExplorEnz3.4.15.4
KEGG Ligand Database for Enzyme Nomenclature3.4.15.4
IUBMB Enzyme Nomenclature3.4.15.4
MEDLINEFind literature relating to 3.4.15.4
MetaCyc3.4.15.4
Rhea expert-curated reactions3.4.15.4

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.15.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-