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ENZYME entry: EC

Accepted Name
Tubulin-glutamate carboxypeptidase.
Alternative Name(s)
Cytosolic carboxypeptidase 1.
Cytosolic carboxypeptidase 5.
Reaction catalysed
  • Detyrosyl-[tubulin] + H(2)O <=> Delta-2-[tubulin] + L-glutamate
  • Delta-2-[tubulin] + H(2)O <=> Delta-3-[tubulin] + L-glutamate
  • This is a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulins.
  • The dual-specificity enzymes can cleave both alpha- and gamma-linked L-glutamate from tubulins, removing the posttranslationally added polyglutamyl side chains from the C-terminal regions.
  • In addition, the enzyme removes two glutamate residues from the C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from which the C-terminal L-tyrosine has been removed by EC
  • The latter is cleaved to Delta-2-tubulin and further to Delta-3- tubulin.
PRIAM enzyme-specific profiles3.4.17.24
KEGG Ligand Database for Enzyme Nomenclature3.4.17.24
IUBMB Enzyme Nomenclature3.4.17.24
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