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ENZYME

ENZYME entry: EC 3.4.17.24

Accepted Name
tubulin-glutamate carboxypeptidase
Alternative Name(s)
CCP5
cytosolic carboxypeptidase 5
Reaction catalysed
  • C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate
  • C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate
Comment(s)
  • This is a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulins.
  • The dual-specificity enzymes can cleave both alpha- and gamma-linked L-glutamate from tubulins, removing the post-translationally added polyglutamyl side chains from the C-terminal regions.
  • In addition, the enzyme removes two glutamate residues from the C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from which the C-terminal L-tyrosine has been removed by EC 3.4.17.17).
  • The latter is cleaved to Delta2-tubulin and further to Delta3- tubulin.
Cross-references
BRENDA3.4.17.24
EC2PDB3.4.17.24
ExplorEnz3.4.17.24
PRIAM enzyme-specific profiles3.4.17.24
KEGG Ligand Database for Enzyme Nomenclature3.4.17.24
IUBMB Enzyme Nomenclature3.4.17.24
IntEnz3.4.17.24
MEDLINEFind literature relating to 3.4.17.24
MetaCyc3.4.17.24
Rhea expert-curated reactions3.4.17.24
UniProtKB/Swiss-Prot
E1C3P4, CBPC1_CHICKQ4U2V3, CBPC1_DANREQ9UPW5, CBPC1_HUMAN
Q641K1, CBPC1_MOUSEQ6DD21, CBPC1_XENLAA9JRL3, CBPC1_XENTR
Q96MI9, CBPC4_HUMANQ09M05, CBPC4_MOUSED2GXM8, CBPC5_AILME
Q58CX9, CBPC5_BOVINQ68EI3, CBPC5_DANREQ8NDL9, CBPC5_HUMAN
Q09M02, CBPC5_MOUSEB2GV17, CBPC5_RATB0JZV4, CBPC5_XENTR
Q5VU57, CBPC6_HUMANQ09LZ8, CBPC6_MOUSE

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