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ENZYME entry: EC 3.4.17.24

Accepted Name
Tubulin-glutamate carboxypeptidase.
Alternative Name(s)
Cytosolic carboxypeptidase 1.
Cytosolic carboxypeptidase 5.
Reaction catalysed
  • Detyrosyl-[tubulin] + H(2)O <=> Delta-2-[tubulin] + L-glutamate
  • Delta-2-[tubulin] + H(2)O <=> Delta-3-[tubulin] + L-glutamate
Comment(s)
  • This is a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulins.
  • The dual-specificity enzymes can cleave both alpha- and gamma-linked L-glutamate from tubulins, removing the posttranslationally added polyglutamyl side chains from the C-terminal regions.
  • In addition, the enzyme removes two glutamate residues from the C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from which the C-terminal L-tyrosine has been removed by EC 3.4.17.17).
  • The latter is cleaved to Delta-2-tubulin and further to Delta-3- tubulin.
Cross-references
BRENDA3.4.17.24
EC2PDB3.4.17.24
ExplorEnz3.4.17.24
PRIAM enzyme-specific profiles3.4.17.24
KEGG Ligand Database for Enzyme Nomenclature3.4.17.24
IUBMB Enzyme Nomenclature3.4.17.24
IntEnz3.4.17.24
MEDLINEFind literature relating to 3.4.17.24
MetaCyc3.4.17.24
Rhea expert-curated reactions3.4.17.24
UniProtKB/Swiss-Prot
E1C3P4, CBPC1_CHICK;  Q4U2V3, CBPC1_DANRE;  Q9UPW5, CBPC1_HUMAN;  
Q641K1, CBPC1_MOUSE;  Q6DD21, CBPC1_XENLA;  A9JRL3, CBPC1_XENTR;  
Q96MI9, CBPC4_HUMAN;  Q09M05, CBPC4_MOUSE;  D2GXM8, CBPC5_AILME;  
Q58CX9, CBPC5_BOVIN;  Q68EI3, CBPC5_DANRE;  Q8NDL9, CBPC5_HUMAN;  
Q09M02, CBPC5_MOUSE;  B2GV17, CBPC5_RAT;  B0JZV4, CBPC5_XENTR;  
Q5VU57, CBPC6_HUMAN;  Q09LZ8, CBPC6_MOUSE;  

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