ENZYME entry: EC 3.4.17.24
Accepted Name |
Tubulin-glutamate carboxypeptidase.
|
Alternative Name(s) |
Cytosolic carboxypeptidase 1. |
Cytosolic carboxypeptidase 5. |
Reaction catalysed |
- Detyrosyl-[tubulin] + H(2)O <=> Delta-2-[tubulin] + L-glutamate
- Delta-2-[tubulin] + H(2)O <=> Delta-3-[tubulin] + L-glutamate
|
Comment(s) |
- This is a subfamily of enzymes that cleave C-terminal and/or side
chain amino acids from tubulins.
- The dual-specificity enzymes can cleave both alpha- and gamma-linked
L-glutamate from tubulins, removing the posttranslationally added
polyglutamyl side chains from the C-terminal regions.
- In addition, the enzyme removes two glutamate residues from the
C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from
which the C-terminal L-tyrosine has been removed by EC 3.4.17.17).
- The latter is cleaved to Delta-2-tubulin and further to Delta-3-
tubulin.
|
Cross-references |
BRENDA | 3.4.17.24 |
EC2PDB | 3.4.17.24 |
ExplorEnz | 3.4.17.24 |
PRIAM enzyme-specific profiles | 3.4.17.24 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.17.24 |
IUBMB Enzyme Nomenclature | 3.4.17.24 |
IntEnz | 3.4.17.24 |
MEDLINE | Find literature relating to 3.4.17.24 |
MetaCyc | 3.4.17.24 |
Rhea expert-curated reactions | 3.4.17.24 |
UniProtKB/Swiss-Prot |
E1C3P4, CBPC1_CHICK; | Q4U2V3, CBPC1_DANRE; | Q9UPW5, CBPC1_HUMAN; |
Q641K1, CBPC1_MOUSE; | Q6DD21, CBPC1_XENLA; | A9JRL3, CBPC1_XENTR; |
Q96MI9, CBPC4_HUMAN; | Q09M05, CBPC4_MOUSE; | D2GXM8, CBPC5_AILME; |
Q58CX9, CBPC5_BOVIN; | Q68EI3, CBPC5_DANRE; | Q8NDL9, CBPC5_HUMAN; |
Q09M02, CBPC5_MOUSE; | B2GV17, CBPC5_RAT; | B0JZV4, CBPC5_XENTR; |
Q5VU57, CBPC6_HUMAN; | Q09LZ8, CBPC6_MOUSE; |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.17.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-