ENZYME entry: EC 3.4.17.24

Accepted Name

tubulin-glutamate carboxypeptidase

Alternative Name(s)

CCP5

cytosolic carboxypeptidase 5

Reaction catalysed

C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate
C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate

Comment(s)

This is a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulins.
The dual-specificity enzymes can cleave both alpha- and gamma-linked L-glutamate from tubulins, removing the post-translationally added polyglutamyl side chains from the C-terminal regions.
In addition, the enzyme removes two glutamate residues from the C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from which the C-terminal L-tyrosine has been removed by EC 3.4.17.17).
The latter is cleaved to Delta2-tubulin and further to Delta3- tubulin.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature

IntEnz

MEDLINE

MetaCyc

Rhea expert-curated reactions

UniProtKB/Swiss-Prot

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.17.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-