Home  |  Contact

ENZYME entry: EC 3.4.17.24

Accepted Name
Tubulin-glutamate carboxypeptidase.
Alternative Name(s)
Cytosolic carboxypeptidase 1.
Cytosolic carboxypeptidase 5.
Reaction catalysed
  • Tubulin + H(O) <=> Delta-2-tubulin + L-glutamate
  • Delta-2-tubulin + H(O) <=> Delta-3-tubulin + L-glutamate
Comment(s)
  • This is a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulins.
  • The dual-specificity enzymes can cleave both alpha- and gamma-linked L-glutamate from tubulins, removing the posttranslationally added polyglutamyl side chains from the C-terminal regions.
  • In addition, the enzyme removes two glutamate residues from the C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from which the C-terminal L-tyrosine has been removed by EC 3.4.17.17).
  • The latter is cleaved to Delta-2-tubulin and further to Delta-3- tubulin.
Cross-references
BRENDA3.4.17.24
EC2PDB3.4.17.24
ExplorEnz3.4.17.24
PRIAM enzyme-specific profiles3.4.17.24
KEGG Ligand Database for Enzyme Nomenclature3.4.17.24
IUBMB Enzyme Nomenclature3.4.17.24
IntEnz3.4.17.24
MEDLINEFind literature relating to 3.4.17.24
MetaCyc3.4.17.24

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.17.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-