ENZYME entry: EC 3.4.17.24
| Accepted Name |
|---|
| Tubulin-glutamate carboxypeptidase.
|
| Alternative Name(s) |
|---|
| Cytosolic carboxypeptidase 1. |
| Cytosolic carboxypeptidase 5. |
| Reaction catalysed |
|---|
- Tubulin + H(O) <=> Delta-2-tubulin + L-glutamate
- Delta-2-tubulin + H(O) <=> Delta-3-tubulin + L-glutamate
|
| Comment(s) |
|---|
- This is a subfamily of enzymes that cleave C-terminal and/or side
chain amino acids from tubulins.
- The dual-specificity enzymes can cleave both alpha- and gamma-linked
L-glutamate from tubulins, removing the posttranslationally added
polyglutamyl side chains from the C-terminal regions.
- In addition, the enzyme removes two glutamate residues from the
C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from
which the C-terminal L-tyrosine has been removed by EC 3.4.17.17).
- The latter is cleaved to Delta-2-tubulin and further to Delta-3-
tubulin.
|
| Cross-references |
|---|
| BRENDA | 3.4.17.24 |
| EC2PDB | 3.4.17.24 |
| ExplorEnz | 3.4.17.24 |
| PRIAM enzyme-specific profiles | 3.4.17.24 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.17.24 |
| IUBMB Enzyme Nomenclature | 3.4.17.24 |
| IntEnz | 3.4.17.24 |
| MEDLINE | Find literature relating to 3.4.17.24 |
| MetaCyc | 3.4.17.24 |
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.17.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-