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ENZYME entry: EC 3.4.19.14

Accepted Name
Leukotriene-C(4) hydrolase.
Alternative Name(s)
Gamma-glutamyl leukotrienase.
Reaction catalysed
Leukotriene C(4) + H(2)O <=> leukotriene D(4) + L-glutamate
Comment(s)
The mouse enzyme is specific for leukotriene C(4), while the human enzyme also has considerable activity toward glutathione and oxidized glutathione (cf. EC 3.4.19.13).
Cross-references
BRENDA3.4.19.14
EC2PDB3.4.19.14
ExplorEnz3.4.19.14
PRIAM enzyme-specific profiles3.4.19.14
KEGG Ligand Database for Enzyme Nomenclature3.4.19.14
IUBMB Enzyme Nomenclature3.4.19.14
IntEnz3.4.19.14
MEDLINEFind literature relating to 3.4.19.14
MetaCyc3.4.19.14
Rhea expert-curated reactions3.4.19.14
UniProtKB/Swiss-Prot
D4B387, GGT1_ARTBC;  P19440, GGT1_HUMAN;  Q60928, GGT1_MOUSE;  
P20735, GGT1_PIG;  P07314, GGT1_RAT;  P36269, GGT5_HUMAN;  
Q9Z2A9, GGT5_MOUSE;  Q9QWE9, GGT5_RAT;  

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