A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.4.19.9
| Accepted Name |
|---|
| Folate gamma-glutamyl hydrolase.
|
| Alternative Name(s) |
|---|
| Carboxypeptidase G. |
| Conjugase. |
| Folate conjugase. |
| Gamma-Glu-X carboxypeptidase. |
| Gamma-glutamyl hydrolase. |
| Lysosomal gamma-glutamyl carboxypeptidase. |
| Pteroyl-poly-alpha-glutamate hydrolase. |
| Tetrahydropteroyl-poly-gamma-glutamyl gamma-glutamyl hydrolase. |
| Reaction catalysed |
|---|
| Tetrahydropteroyl-(gamma-glutamyl)(n) + (n-1) H(2)O <=> 5,6,7,8-tetrahydrofolate + (n-1) L-glutamate |
| Comment(s) |
|---|
- The enzyme, which occurs only in animals and plants, can be either
endo- and/or exopeptidase.
- It acts on tetrahydropteroyl polyglutamates and their modified forms,
as well as the polyglutamates of the folate breakdown product
N-(4-aminobenzoyl)-L-glutamate (pABA-Glu).
- The initial cleavage may release either monoglutamate or poly-gamma-
glutamate of two or more residues, depending on the specific enzyme.
- For example, GGH1 from the plant Arabidopsis thaliana cleaves
pentaglutamates, mainly to di- and triglutamates, whereas GGH2 from
the same organism yields mainly monoglutamates.
- The enzyme is lysosomal (and secreted) in animals and vacuolar in
plants.
- Belongs to peptidase family C26.
- Formerly EC 3.4.12.10 and EC 3.4.22.12.
|
| Cross-references |
|---|
| PROSITE | PDOC51275 |
| BRENDA | 3.4.19.9 |
| EC2PDB | 3.4.19.9 |
| ExplorEnz | 3.4.19.9 |
| PRIAM enzyme-specific profiles | 3.4.19.9 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.19.9 |
| IUBMB Enzyme Nomenclature | 3.4.19.9 |
| IntEnz | 3.4.19.9 |
| MEDLINE | Find literature relating to 3.4.19.9 |
| MetaCyc | 3.4.19.9 |
| UniProtKB/Swiss-Prot |
| Q9SYL6, GGH1_ARATH; | O65355, GGH2_ARATH; | Q9ZV85, GGH3_ARATH; |
| Q54LN4, GGHA_DICDI; | Q54HL4, GGHB_DICDI; | A7YWG4, GGH_BOVIN; |
| Q92820, GGH_HUMAN; | Q9Z0L8, GGH_MOUSE; | Q62867, GGH_RAT; |
| P93164, GGH_SOYBN; |
|
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