ENZYME

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.19.9

Accepted Name

Folate gamma-glutamyl hydrolase.

Alternative Name(s)

Carboxypeptidase G.

Conjugase.

Folate conjugase.

Gamma-Glu-X carboxypeptidase.

Gamma-glutamyl hydrolase.

Lysosomal gamma-glutamyl carboxypeptidase.

Pteroyl-poly-alpha-glutamate hydrolase.

Tetrahydropteroyl-poly-gamma-glutamyl gamma-glutamyl hydrolase.

Reaction catalysed

Tetrahydropteroyl-(gamma-glutamyl)(n) + (n-1) H(2)O <=> 5,6,7,8-tetrahydrofolate + (n-1) L-glutamate

Comment(s)

The enzyme, which occurs only in animals and plants, can be either endo- and/or exopeptidase.
It acts on tetrahydropteroyl polyglutamates and their modified forms, as well as the polyglutamates of the folate breakdown product N-(4-aminobenzoyl)-L-glutamate (pABA-Glu).
The initial cleavage may release either monoglutamate or poly-gamma- glutamate of two or more residues, depending on the specific enzyme.
For example, GGH1 from the plant Arabidopsis thaliana cleaves pentaglutamates, mainly to di- and triglutamates, whereas GGH2 from the same organism yields mainly monoglutamates.
The enzyme is lysosomal (and secreted) in animals and vacuolar in plants.
Belongs to peptidase family C26.
Formerly EC 3.4.12.10 and EC 3.4.22.12.

Cross-references

PROSITE

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature

IntEnz

MEDLINE

MetaCyc

UniProtKB/Swiss-Prot

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