ENZYME entry: EC 3.4.19.9
Accepted Name |
Folate gamma-glutamyl hydrolase.
|
Alternative Name(s) |
Carboxypeptidase G. |
Conjugase. |
Folate conjugase. |
Gamma-Glu-X carboxypeptidase. |
Gamma-glutamyl hydrolase. |
Lysosomal gamma-glutamyl carboxypeptidase. |
Pteroyl-poly-alpha-glutamate hydrolase. |
Tetrahydropteroyl-poly-gamma-glutamyl gamma-glutamyl hydrolase. |
Reaction catalysed |
Tetrahydropteroyl-(gamma-glutamyl)(n) + (n-1) H(2)O <=> 5,6,7,8-tetrahydrofolate + (n-1) L-glutamate |
Comment(s) |
- The enzyme, which occurs only in animals and plants, can be either
endo- and/or exopeptidase.
- It acts on tetrahydropteroyl polyglutamates and their modified forms,
as well as the polyglutamates of the folate breakdown product
N-(4-aminobenzoyl)-L-glutamate (pABA-Glu).
- The initial cleavage may release either monoglutamate or poly-gamma-
glutamate of two or more residues, depending on the specific enzyme.
- For example, GGH1 from the plant Arabidopsis thaliana cleaves
pentaglutamates, mainly to di- and triglutamates, whereas GGH2 from
the same organism yields mainly monoglutamates.
- The enzyme is lysosomal (and secreted) in animals and vacuolar in
plants.
- Belongs to peptidase family C26.
- Formerly EC 3.4.12.10 and EC 3.4.22.12.
|
Cross-references |
PROSITE | PDOC51275 |
BRENDA | 3.4.19.9 |
EC2PDB | 3.4.19.9 |
ExplorEnz | 3.4.19.9 |
PRIAM enzyme-specific profiles | 3.4.19.9 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.19.9 |
IUBMB Enzyme Nomenclature | 3.4.19.9 |
IntEnz | 3.4.19.9 |
MEDLINE | Find literature relating to 3.4.19.9 |
MetaCyc | 3.4.19.9 |
Rhea expert-curated reactions | 3.4.19.9 |
UniProtKB/Swiss-Prot |
Q9SYL6, GGH1_ARATH; | O65355, GGH2_ARATH; | Q9ZV85, GGH3_ARATH; |
Q54LN4, GGHA_DICDI; | Q54HL4, GGHB_DICDI; | A7YWG4, GGH_BOVIN; |
Q92820, GGH_HUMAN; | Q9Z0L8, GGH_MOUSE; | Q62867, GGH_RAT; |
P93164, GGH_SOYBN; |
|
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