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ENZYME entry: EC 3.4.19.9

Accepted Name
folate gamma-glutamyl hydrolase.
Alternative Name(s)
carboxypeptidase G.
conjugase.
folate conjugase.
gamma-glutamyl hydrolase.
gamma-Glu-X carboxypeptidase.
lysosomal gamma-glutamyl carboxypeptidase.
pteroyl-poly-alpha-glutamate hydrolase.
tetrahydropteroyl-poly-gamma-glutamyl gamma-glutamyl hydrolase.
Reaction catalysed
(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O <=> (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate
Comment(s)
  • The enzyme, which occurs only in animals and plants, can be either endo- and/or exopeptidase.
  • It acts on tetrahydropteroyl polyglutamates and their modified forms, as well as the polyglutamates of the folate breakdown product N-(4-aminobenzoyl)-L-glutamate (pABA-Glu).
  • The initial cleavage may release either monoglutamate or poly-gamma- glutamate of two or more residues, depending on the specific enzyme.
  • For example, GGH1 from the plant Arabidopsis thaliana cleaves pentaglutamates, mainly to di- and triglutamates, whereas GGH2 from the same organism yields mainly monoglutamates.
  • The enzyme is lysosomal (and secreted) in animals and vacuolar in plants.
  • Belongs to peptidase family C26.
  • Formerly EC 3.4.12.10 and EC 3.4.22.12.
Cross-references
BRENDA3.4.19.9
EC2PDB3.4.19.9
ExplorEnz3.4.19.9
PRIAM enzyme-specific profiles3.4.19.9
KEGG Ligand Database for Enzyme Nomenclature3.4.19.9
IUBMB Enzyme Nomenclature3.4.19.9
IntEnz3.4.19.9
MEDLINEFind literature relating to 3.4.19.9
MetaCyc3.4.19.9
Rhea expert-curated reactions3.4.19.9
UniProtKB/Swiss-Prot
Q9SYL6, GGH1_ARATH;  O65355, GGH2_ARATH;  Q9ZV85, GGH3_ARATH;  
Q54LN4, GGHA_DICDI;  Q54HL4, GGHB_DICDI;  A7YWG4, GGH_BOVIN;  
Q92820, GGH_HUMAN;  Q9Z0L8, GGH_MOUSE;  Q62867, GGH_RAT;  
P93164, GGH_SOYBN;  

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