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ENZYME entry: EC

Accepted Name
C-terminal processing peptidase.
Alternative Name(s)
photosystem II D1 protein processing peptidase.
protease Re.
tail-specific protease.
Tsp protease.
Reaction catalysed
The enzyme shows specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala-Ala-|-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala
  • In the plant chloroplast, the enzyme removes the C-terminal extension of the D1 polypeptide of photosystem II; this proteolytic processing is necessary to allow the light-driven assembly of the tetranuclear manganese cluster, which is responsible for photosynthetic water oxidation.
  • Belongs to peptidase family S41.
PRIAM enzyme-specific profiles3.4.21.102
KEGG Ligand Database for Enzyme Nomenclature3.4.21.102
IUBMB Enzyme Nomenclature3.4.21.102
MEDLINEFind literature relating to
Rhea expert-curated reactions3.4.21.102
O34666, CTPA_BACSU;  Q44879, CTPA_BARBK;  P42784, CTPA_SYNP2;  
Q55669, CTPA_SYNY3;  O04073, CTPA_TETOB;  O35002, CTPB_BACSU;  
P23865, PRC_ECOLI;  P45306, PRC_HAEIN;  P43669, PRC_SALTY;  

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