ENZYME entry: EC 3.4.21.103
| Accepted Name |
|---|
| Physarolisin.
|
| Alternative Name(s) |
|---|
| Dictyostelium discoideum aspartic proteinase. |
| Dictyostelium discoideum aspartic proteinase E. |
| Physaropepsin. |
| Physarum aspartic proteinase. |
| Physarum flavicomum aspartic proteinase. |
| Physarum polycephalum acid proteinase. |
| Reaction catalysed |
|---|
| Milk clotting activity. Preferential cleavage of 8-Gly-|-Ser-9 in B chain of insulin most rapidly, followed by 11-Leu-|-Val-12, 19-Cys(SO(3)H)-|-Gly and 24-Phe-|-Phe-25. No action on Ac-Phe-Tyr(I)(2) |
| Comment(s) |
|---|
- From the slime mold Physarum polycephalum.
- Is not inhibited by pepstatin, but is blocked by methyl
2-diazoacetamidohexanoate.
- Closely similar enzymes are found in Dictyostelium discoideum and
P.flavicomum.
- Belongs to peptidase family S53.
- Formerly EC 3.4.4.17, EC 3.4.23.6 and EC 3.4.23.27.
|
| Cross-references |
|---|
| BRENDA | 3.4.21.103 |
| EC2PDB | 3.4.21.103 |
| ExplorEnz | 3.4.21.103 |
| PRIAM enzyme-specific profiles | 3.4.21.103 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.103 |
| IUBMB Enzyme Nomenclature | 3.4.21.103 |
| IntEnz | 3.4.21.103 |
| MEDLINE | Find literature relating to 3.4.21.103 |
| MetaCyc | 3.4.21.103 |
| UniProtKB/Swiss-Prot |
|
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