Expasy logo

ENZYME

ENZYME entry: EC 3.4.21.106

PURL: https://purl.expasy.org/enzyme/EC/3.4.21.106
Accepted Name
hepsin
Reaction catalysed
Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys
Comment(s)
  • This type-II membrane-associated serine peptidase has been implicated in cell growth and development.
  • The enzyme has been shown to activate blood coagulation factor VII by cleavage of the 152-Arg-|-Ile-153 peptide bound in BHK cells, thus indicating a possible role in the initiation of blood coagulation.
  • There is no cleavage after aromatic or aliphatic residues.
  • The occupancy of the S2 site is an absolute requirement for catalysis and a basic residue at that site is preferred to an aliphatic residue.
  • The nature of the residue at S3 also affects hydrolysis, with Gln being much more favorable than Ala.
  • Belongs to peptidase family S1A.
Cross-references
Rhea expert-curated reactions3.4.21.106
ExplorEnz3.4.21.106
IUBMB Enzyme Nomenclature3.4.21.106
UniProtKB/Swiss-Prot
P05981, HEPS_HUMANO35453, HEPS_MOUSEQ5R5E8, HEPS_PONAB
Q05511, HEPS_RAT
BRENDA3.4.21.106
MetaCyc3.4.21.106
KEGG Ligand Database for Enzyme Nomenclature3.4.21.106
EC2PDB3.4.21.106
MEDLINEFind literature relating to 3.4.21.106

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-