A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 220.127.116.11
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|High temperature requirement protein A2.|
|Omi stress-regulated endoprotease.|
|Serine proteinase OMI.|
|Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues|
- Up-regulated in mammalian cells in response to stress induced by both
heat shock and tunicamycin treatment.
- Can induce apoptosis in a caspase-independent manner through its
peptidase activity and in a caspase-dependent manner by disrupting
the interaction between caspase and the inhibitor of apoptosis (IAP).
- Belongs to peptidase family S1B.
|PRIAM enzyme-specific profiles||18.104.22.168|
|KEGG Ligand Database for Enzyme Nomenclature||22.214.171.124|
|IUBMB Enzyme Nomenclature||126.96.36.199|
|MEDLINE||Find literature relating to 188.8.131.52|
|A0JNK3, HTRA2_BOVIN; ||B3LVG7, HTRA2_DROAN; ||B3P3J9, HTRA2_DROER; |
|B4JTT7, HTRA2_DROGR; ||Q9VFJ3, HTRA2_DROME; ||B4K835, HTRA2_DROMO; |
|B4G316, HTRA2_DROPE; ||Q297U2, HTRA2_DROPS; ||B4HEM8, HTRA2_DROSE; |
|B4QZU6, HTRA2_DROSI; ||B4LY58, HTRA2_DROVI; ||B4N937, HTRA2_DROWI; |
|B4PST0, HTRA2_DROYA; ||O43464, HTRA2_HUMAN; ||Q9JIY5, HTRA2_MOUSE; |
entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-