Expasy logo

ENZYME

ENZYME entry: EC 3.4.21.108

PURL: https://purl.expasy.org/enzyme/EC/3.4.21.108
Accepted Name
HtrA2 peptidase
Alternative Name(s)
high temperature requirement protein A2
HtrA2 protease
Omi stress-regulated endoprotease
serine proteinase OMI
Reaction catalysed
Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues
Comment(s)
  • Up-regulated in mammalian cells in response to stress induced by both heat shock and tunicamycin treatment.
  • Can induce apoptosis in a caspase-independent manner through its peptidase activity and in a caspase-dependent manner by disrupting the interaction between caspase and the inhibitor of apoptosis (IAP).
  • Belongs to peptidase family S1B.
Cross-references
BRENDA3.4.21.108
EC2PDB3.4.21.108
ExplorEnz3.4.21.108
KEGG Ligand Database for Enzyme Nomenclature3.4.21.108
IUBMB Enzyme Nomenclature3.4.21.108
MEDLINEFind literature relating to 3.4.21.108
MetaCyc3.4.21.108
Rhea expert-curated reactions3.4.21.108
UniProtKB/Swiss-Prot
A0JNK3, HTRA2_BOVINB3LVG7, HTRA2_DROANB3P3J9, HTRA2_DROER
B4JTT7, HTRA2_DROGRQ9VFJ3, HTRA2_DROMEB4K835, HTRA2_DROMO
B4G316, HTRA2_DROPEQ297U2, HTRA2_DROPSB4HEM8, HTRA2_DROSE
B4QZU6, HTRA2_DROSIB4LY58, HTRA2_DROVIB4N937, HTRA2_DROWI
B4PST0, HTRA2_DROYAO43464, HTRA2_HUMANQ9JIY5, HTRA2_MOUSE

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-