A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.4.21.110
Accepted Name |
C5a peptidase.
|
Alternative Name(s) |
SCP. |
Streptococcal C5a peptidase. |
Reaction catalysed |
The primary cleavage site is at 67-His-|-Lys-68 in human C5a with a minor secondary cleavage site at 58-Ala-|-Ser-59 |
Comment(s) |
- Surface-associated subtilisin-like serine peptidase with very
specific substrate specificity.
- Virulent strains of streptococci, including Streptococcus pyogenes,
can evade human detection and phagocytosis by destroying the
complement chemotaxin C5a.
- Cleavage of human C5a by this enzyme reduces the ability of C5a to
bind receptors on the surface of polymorphonuclear neutrophil
leukocytes (PMNLs) and thereby abolishes its chemotactic properties.
- Belongs to peptidase family S8A.
|
Cross-references |
PROSITE | PDOC00125 |
BRENDA | 3.4.21.110 |
EC2PDB | 3.4.21.110 |
ExplorEnz | 3.4.21.110 |
PRIAM enzyme-specific profiles | 3.4.21.110 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.110 |
IUBMB Enzyme Nomenclature | 3.4.21.110 |
IntEnz | 3.4.21.110 |
MEDLINE | Find literature relating to 3.4.21.110 |
MetaCyc | 3.4.21.110 |
UniProtKB/Swiss-Prot |
|
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UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
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