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ENZYME

ENZYME entry: EC 3.4.21.112

PURL: https://purl.expasy.org/enzyme/EC/3.4.21.112
Accepted Name
site-1 protease
Alternative Name(s)
mammalian subtilisin/kexin isozyme 1
membrane-bound transcription factor site-1 protease
proprotein convertase SKI-1
proprotein convertase SKI-1/S1PPS1
S1P endopeptidase
S1P protease
site-1 peptidase
SKI-1
SREBP-1 proteinase
SREBP-2 proteinase
SREBP proteinase
SREBP S1 protease
sterol-regulated luminal protease
sterol regulatory element-binding protein proteinase
sterol regulatory element-binding protein site 1 protease
subtilase SKI-1
subtilase SKI-1/S1P
subtilisin/kexin isozyme 1
Reaction catalysed
Processes precursors containing basic and hydrophobic/aliphatic residues at P4 and P2, respectively, with a relatively relaxed acceptance of amino acids at P1 and P3
Comment(s)
  • Cleaves sterol regulatory element-binding proteins (SREBPs) and thereby initiates a process by which the active fragments of the SREBPs translocate to the nucleus and activate genes controlling the synthesis and uptake of cholesterol and unsaturated fatty acids into the bloodstream.
  • The enzyme also processes pro-brain-derived neurotrophic factor and undergoes autocatalytic activation in the endoplasmic reticulum through sequential cleavages.
  • The enzyme can also process the unfolded protein response stress factor ATF6 at an Arg-His-Lys-Lys-|- site, and the envelope glycoprotein of the highly infectious Lassa virus and Crimean Congo hemorrhagic fever virus at Arg-Arg-Lys-Lys-|-.
  • Belongs to peptidase family S8A.
Cross-references
BRENDA3.4.21.112
EC2PDB3.4.21.112
ExplorEnz3.4.21.112
KEGG Ligand Database for Enzyme Nomenclature3.4.21.112
IUBMB Enzyme Nomenclature3.4.21.112
MEDLINEFind literature relating to 3.4.21.112
MetaCyc3.4.21.112
Rhea expert-curated reactions3.4.21.112
UniProtKB/Swiss-Prot
Q9Z2A8, MBTP1_CRIGRQ14703, MBTP1_HUMANQ9WTZ2, MBTP1_MOUSE
Q9WTZ3, MBTP1_RAT

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