ENZYME entry: EC 3.4.21.112
Accepted Name |
Site-1 protease.
|
Alternative Name(s) |
Mammalian subtilisin/kexin isozyme 1. |
Membrane-bound transcription factor site-1 protease. |
Proprotein convertase SKI-1. |
Proprotein convertase SKI-1/S1PPS1. |
S1P endopeptidase. |
S1P protease. |
Site-1 peptidase. |
SKI-1. |
SREBP proteinase. |
SREBP S1 protease. |
SREBP-1 proteinase. |
SREBP-2 proteinase. |
Sterol regulatory element-binding protein proteinase. |
Sterol regulatory element-binding protein site 1 protease. |
Sterol-regulated luminal protease. |
Subtilase SKI-1. |
Subtilase SKI-1/S1P. |
Subtilisin/kexin isozyme 1. |
Reaction catalysed |
Processes precursors containing basic and hydrophobic/aliphatic residues at P4 and P2, respectively, with a relatively relaxed acceptance of amino acids at P1 and P3 |
Comment(s) |
- Cleaves sterol regulatory element-binding proteins (SREBPs) and
thereby initiates a process by which the active fragments of the
SREBPs translocate to the nucleus and activate genes controlling the
synthesis and uptake of cholesterol and unsaturated fatty acids into
the bloodstream.
- The enzyme also processes pro-brain-derived neurotrophic factor and
undergoes autocatalytic activation in the endoplasmic reticulum
through sequential cleavages.
- The enzyme can also process the unfolded protein response stress
factor ATF6 at an Arg-His-Lys-Lys-|- site, and the envelope
glycoprotein of the highly infectious Lassa virus and Crimean Congo
hemorrhagic fever virus at Arg-Arg-Lys-Lys-|-.
- Belongs to peptidase family S8A.
|
Cross-references |
PROSITE | PDOC00125 |
BRENDA | 3.4.21.112 |
EC2PDB | 3.4.21.112 |
ExplorEnz | 3.4.21.112 |
PRIAM enzyme-specific profiles | 3.4.21.112 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.112 |
IUBMB Enzyme Nomenclature | 3.4.21.112 |
IntEnz | 3.4.21.112 |
MEDLINE | Find literature relating to 3.4.21.112 |
MetaCyc | 3.4.21.112 |
UniProtKB/Swiss-Prot |
|
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