ENZYME

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ENZYME entry: EC 3.4.21.113

Accepted Name

Pestivirus NS3 polyprotein peptidase.

Alternative Name(s)

BDV NS3 endopeptidase.

Border disease virus NS3 endopeptidase.

Bovine viral diarrhea virus NS3 endopeptidase.

BVDV NS3 endopeptidase.

Classical swine fever virus NS3 endopeptidase.

CSFV NS3 endopeptidase.

Reaction catalysed

Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites

Comment(s)

The polyprotein of noncytopathogenic pestiviruses is cleaved co- and post-translationally into at least 11 proteins (N(pro), C, E(rns), E1, E2, p7, NS2-3, NS4A, NS4B, NS5A, and NS5B).
The genomes of cytopathogenic pestivirus strains express at least one additional protein, called NS3 (p80).
This enzyme, which resides in the N-terminal region of NS3 (nonstructural protein 3), is essential for generation of its own C-terminus and for processing of the downstream cleavage sites, leading to the release of the pestivirus nonstructural proteins NS4A, NS4B, NS5A and NS5B.
Belongs to peptidase family S31.

Cross-references

BRENDA

3.4.21.113

EC2PDB

3.4.21.113

ExplorEnz

3.4.21.113

PRIAM enzyme-specific profiles

3.4.21.113

KEGG Ligand Database for Enzyme Nomenclature

3.4.21.113

IUBMB Enzyme Nomenclature