ENZYME entry: EC 3.4.21.113
| Accepted Name |
|---|
| Pestivirus NS3 polyprotein peptidase.
|
| Alternative Name(s) |
|---|
| BDV NS3 endopeptidase. |
| Border disease virus NS3 endopeptidase. |
| Bovine viral diarrhea virus NS3 endopeptidase. |
| BVDV NS3 endopeptidase. |
| Classical swine fever virus NS3 endopeptidase. |
| CSFV NS3 endopeptidase. |
| Reaction catalysed |
|---|
| Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites |
| Comment(s) |
|---|
- The polyprotein of noncytopathogenic pestiviruses is cleaved co- and
post-translationally into at least 11 proteins (N(pro), C, E(rns),
E1, E2, p7, NS2-3, NS4A, NS4B, NS5A, and NS5B).
- The genomes of cytopathogenic pestivirus strains express at least one
additional protein, called NS3 (p80).
- This enzyme, which resides in the N-terminal region of NS3
(nonstructural protein 3), is essential for generation of its own
C-terminus and for processing of the downstream cleavage sites,
leading to the release of the pestivirus nonstructural proteins NS4A,
NS4B, NS5A and NS5B.
- Belongs to peptidase family S31.
|
| Cross-references |
|---|
| BRENDA | 3.4.21.113 |
| EC2PDB | 3.4.21.113 |
| ExplorEnz | 3.4.21.113 |
| PRIAM enzyme-specific profiles | 3.4.21.113 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.113 |
| IUBMB Enzyme Nomenclature | 3.4.21.113 |
| IntEnz | 3.4.21.113 |
| MEDLINE | Find literature relating to 3.4.21.113 |
| MetaCyc | 3.4.21.113 |
| Rhea expert-curated reactions | 3.4.21.113 |
| UniProtKB/Swiss-Prot |
|
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