ENZYME entry: EC 22.214.171.124
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|Pestivirus NS3 polyprotein peptidase.
|BDV NS3 endopeptidase.|
|Border disease virus NS3 endopeptidase.|
|Bovine viral diarrhea virus NS3 endopeptidase.|
|BVDV NS3 endopeptidase.|
|Classical swine fever virus NS3 endopeptidase.|
|CSFV NS3 endopeptidase.|
|Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites|
- The polyprotein of noncytopathogenic pestiviruses is cleaved co- and
post-translationally into at least 11 proteins (N(pro), C, E(rns),
E1, E2, p7, NS2-3, NS4A, NS4B, NS5A, and NS5B).
- The genomes of cytopathogenic pestivirus strains express at least one
additional protein, called NS3 (p80).
- This enzyme, which resides in the N-terminal region of NS3
(nonstructural protein 3), is essential for generation of its own
C-terminus and for processing of the downstream cleavage sites,
leading to the release of the pestivirus nonstructural proteins NS4A,
NS4B, NS5A and NS5B.
- Belongs to peptidase family S31.
|PRIAM enzyme-specific profiles||126.96.36.199|
|KEGG Ligand Database for Enzyme Nomenclature||188.8.131.52|
|IUBMB Enzyme Nomenclature||184.108.40.206|
|MEDLINE||Find literature relating to 220.127.116.11|
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