ENZYME entry: EC 3.4.21.114
Accepted Name |
Equine arterivirus serine peptidase.
|
Alternative Name(s) |
3C-like Ser protease. |
3C-like serine protease. |
3CLSP. |
Arterivirus NSP4. |
Chymotrypsin-like serine proteinase nsp4. |
Equine arteritis virus serine peptidase. |
Nonstructural protein 4 serine protease. |
Reaction catalysed |
Cleavage of (Glu/Gln)-|-(Gly/Ser/Ala) in arterivirus replicase translation products ORF1a and ORF1ab |
Comment(s) |
- In the equine arterivirus (EAV), the replicase gene is translated
into open reading frame 1a (ORF1a) and ORF1ab polyproteins.
- This enzyme is the main viral proteinase and processes five cleavage
sites in the ORF1a protein and three in the ORF1b-encoded part of the
ORF1ab protein to yield nonstructural proteins (nsp5-nsp12).
- It combines the catalytic system of a chymotrypsin-like serine
peptidase (His-Asp-Ser catalytic triad) with the substrate
specificity of a 3C-like serine peptidase (Glu or Gln) at the P1
position and a small amino-acid residue (Gly, Ser or Ala) at the P1'
position.
- Cleavage of ORF1ab by this enzyme is essential for viral replication.
- Belongs to peptidase family S32.
|
Cross-references |
BRENDA | 3.4.21.114 |
EC2PDB | 3.4.21.114 |
ExplorEnz | 3.4.21.114 |
PRIAM enzyme-specific profiles | 3.4.21.114 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.114 |
IUBMB Enzyme Nomenclature | 3.4.21.114 |
IntEnz | 3.4.21.114 |
MEDLINE | Find literature relating to 3.4.21.114 |
MetaCyc | 3.4.21.114 |
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ENZYME /
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