ENZYME entry: EC 3.4.21.114
| Accepted Name |
|---|
| Equine arterivirus serine peptidase.
|
| Alternative Name(s) |
|---|
| 3C-like Ser protease. |
| 3C-like serine protease. |
| 3CLSP. |
| Arterivirus NSP4. |
| Chymotrypsin-like serine proteinase nsp4. |
| Equine arteritis virus serine peptidase. |
| Nonstructural protein 4 serine protease. |
| Reaction catalysed |
|---|
| Cleavage of (Glu/Gln)-|-(Gly/Ser/Ala) in arterivirus replicase translation products ORF1a and ORF1ab |
| Comment(s) |
|---|
- In the equine arterivirus (EAV), the replicase gene is translated
into open reading frame 1a (ORF1a) and ORF1ab polyproteins.
- This enzyme is the main viral proteinase and processes five cleavage
sites in the ORF1a protein and three in the ORF1b-encoded part of the
ORF1ab protein to yield nonstructural proteins (nsp5-nsp12).
- It combines the catalytic system of a chymotrypsin-like serine
peptidase (His-Asp-Ser catalytic triad) with the substrate
specificity of a 3C-like serine peptidase (Glu or Gln) at the P1
position and a small amino-acid residue (Gly, Ser or Ala) at the P1'
position.
- Cleavage of ORF1ab by this enzyme is essential for viral replication.
- Belongs to peptidase family S32.
|
| Cross-references |
|---|
| BRENDA | 3.4.21.114 |
| EC2PDB | 3.4.21.114 |
| ExplorEnz | 3.4.21.114 |
| PRIAM enzyme-specific profiles | 3.4.21.114 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.114 |
| IUBMB Enzyme Nomenclature | 3.4.21.114 |
| IntEnz | 3.4.21.114 |
| MEDLINE | Find literature relating to 3.4.21.114 |
| MetaCyc | 3.4.21.114 |
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-