ENZYME entry: EC 3.4.21.115
| Accepted Name |
|---|
| Infectious pancreatic necrosis birnavirus Vp4 peptidase.
|
| Alternative Name(s) |
|---|
| Infectious pancreatic necrosis virus protease. |
| IPNV Vp4 peptidase. |
| IPNV Vp4 protease. |
| NS protease. |
| NS-associated protease. |
| Vp4 protease. |
| Reaction catalysed |
|---|
| Cleaves the (Ser/Thr)-Xaa-Ala-|-(Ser/Ala)-Gly motif in the polyprotein NH(2)-pVP2-VP4-VP3-COOH of infectious pancreatic necrosis virus at the pVP2-VP4 and VP4-VP3 junctions |
| Comment(s) |
|---|
- Infectious pancreatic necrosis virus (IPNV) is a birnavirus that
causes an acute, contagious disease in young salmonid fish.
- As with most viruses that infect eukaryotic cells, the proteolytic
processing of viral precursor proteins is a crucial step in the life
cycle of this virus.
- pVP2 is converted into VP2 by cleavage near the carboxy end of pVP2;
this cleavage is most likely due to host-cell proteases rather than
VP4.
- Differs from most serine peptidases in not having the catalytic triad
Ser-His-Asp.
- Belongs to peptidase family S50.
|
| Cross-references |
|---|
| BRENDA | 3.4.21.115 |
| EC2PDB | 3.4.21.115 |
| ExplorEnz | 3.4.21.115 |
| PRIAM enzyme-specific profiles | 3.4.21.115 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.115 |
| IUBMB Enzyme Nomenclature | 3.4.21.115 |
| IntEnz | 3.4.21.115 |
| MEDLINE | Find literature relating to 3.4.21.115 |
| MetaCyc | 3.4.21.115 |
| Rhea expert-curated reactions | 3.4.21.115 |
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