ENZYME

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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.21.115

Accepted Name
Infectious pancreatic necrosis birnavirus Vp4 peptidase.
Alternative Name(s)
Infectious pancreatic necrosis virus protease.
IPNV Vp4 peptidase.
IPNV Vp4 protease.
NS protease.
NS-associated protease.
Vp4 protease.
Reaction catalysed
Cleaves the (Ser/Thr)-Xaa-Ala-\|-(Ser/Ala)-Gly motif in the polyprotein NH(2)-pVP2-VP4-VP3-COOH of infectious pancreatic necrosis virus at the pVP2-VP4 and VP4-VP3 junctions
Comment(s)
Infectious pancreatic necrosis virus (IPNV) is a birnavirus that causes an acute, contagious disease in young salmonid fish. As with most viruses that infect eukaryotic cells, the proteolytic processing of viral precursor proteins is a crucial step in the life cycle of this virus. pVP2 is converted into VP2 by cleavage near the carboxy end of pVP2; this cleavage is most likely due to host-cell proteases rather than VP4. Differs from most serine peptidases in not having the catalytic triad Ser-His-Asp. Belongs to peptidase family S50.
Cross-references
BRENDA	3.4.21.115
EC2PDB	3.4.21.115
ExplorEnz	3.4.21.115
PRIAM enzyme-specific profiles	3.4.21.115
KEGG Ligand Database for Enzyme Nomenclature	3.4.21.115
IUBMB Enzyme Nomenclature	3.4.21.115
IntEnz	3.4.21.115
MEDLINE	Find literature relating to 3.4.21.115
MetaCyc	3.4.21.115