A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.4.21.116
| Accepted Name |
|---|
| SpoIVB peptidase.
|
| Alternative Name(s) |
|---|
| Sporulation factor IV B protease. |
| Stage IV sporulation protein B. |
| Reaction catalysed |
|---|
| Self-cleaves 52-Val-|-Asn-53, 62-Ala-|-Phe-63 and 74-Val-|-Thr-75 at the N-terminus of SpoIVB |
| Comment(s) |
|---|
- This enzyme plays a central role in a regulatory checkpoint (the
sigma(K) checkpoint), which coordinates gene expression during the
later stages of spore formation in Bacillus subtilis.
- The enzyme activates proteolytic processing of a sporulation-specific
sigma factor, pro-sigma(K), to its mature and active form, sigma(K),
by self-cleavage.
- The enzyme is also subject to secondary proteolysis, which presumably
inactivates SpoIVB.
- The enzyme is also essential for the formation of heat-resistant
spores.
- Belongs to peptidase family S55.
|
| Cross-references |
|---|
| PROSITE | PDOC51494 |
| BRENDA | 3.4.21.116 |
| EC2PDB | 3.4.21.116 |
| ExplorEnz | 3.4.21.116 |
| PRIAM enzyme-specific profiles | 3.4.21.116 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.116 |
| IUBMB Enzyme Nomenclature | 3.4.21.116 |
| IntEnz | 3.4.21.116 |
| MEDLINE | Find literature relating to 3.4.21.116 |
| MetaCyc | 3.4.21.116 |
| UniProtKB/Swiss-Prot |
|
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