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ENZYME entry: EC 3.4.21.118

Accepted Name
Kallikrein 8.
Alternative Name(s)
Neuropsin.
Ovasin.
Serine protease 19.
TADG-14.
Tumor-associated differentially expressed gene 14.
Reaction catalysed
Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys
Comment(s)
  • Activated by removal of an N-terminal prepropeptide.
  • The highest amidolytic activity is observed using Boc-Val-Pro- Arg-|-7-amido-4-methylcoumarin, which is a substrate of alpha- thrombin.
  • Substrates lacking basic amino acids in the P1 position are not cleaved.
  • Degrades casein, fibronectin, gelatin, collagen type IV, fibrinogen, and high-molecular-mass kininogen and is associated with diseases such as ovarian cancer and Alzheimer's disease.
  • Belongs to peptidase family S1A.
Cross-references
PROSITEPDOC00124
BRENDA3.4.21.118
EC2PDB3.4.21.118
ExplorEnz3.4.21.118
PRIAM enzyme-specific profiles3.4.21.118
KEGG Ligand Database for Enzyme Nomenclature3.4.21.118
IUBMB Enzyme Nomenclature3.4.21.118
IntEnz3.4.21.118
MEDLINEFind literature relating to 3.4.21.118
MetaCyc3.4.21.118
Rhea expert-curated reactions3.4.21.118
UniProtKB/Swiss-Prot
O60259, KLK8_HUMAN;  Q61955, KLK8_MOUSE;  O88780, KLK8_RAT;  

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