ENZYME

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.21.118

Accepted Name

Kallikrein 8.

Alternative Name(s)

Neuropsin.

Ovasin.

Serine protease 19.

TADG-14.

Tumor-associated differentially expressed gene 14.

Reaction catalysed

Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys

Comment(s)

Activated by removal of an N-terminal prepropeptide.
The highest amidolytic activity is observed using Boc-Val-Pro- Arg-|-7-amido-4-methylcoumarin, which is a substrate of alpha- thrombin.
Substrates lacking basic amino acids in the P1 position are not cleaved.
Degrades casein, fibronectin, gelatin, collagen type IV, fibrinogen, and high-molecular-mass kininogen and is associated with diseases such as ovarian cancer and Alzheimer's disease.
Belongs to peptidase family S1A.

Cross-references

PROSITE

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature