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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Kallikrein 8.
Alternative Name(s)
Serine protease 19.
Tumor-associated differentially expressed gene 14.
Reaction catalysed
Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys
  • Activated by removal of an N-terminal prepropeptide.
  • The highest amidolytic activity is observed using Boc-Val-Pro- Arg-|-7-amido-4-methylcoumarin, which is a substrate of alpha- thrombin.
  • Substrates lacking basic amino acids in the P1 position are not cleaved.
  • Degrades casein, fibronectin, gelatin, collagen type IV, fibrinogen, and high-molecular-mass kininogen and is associated with diseases such as ovarian cancer and Alzheimer's disease.
  • Belongs to peptidase family S1A.
PRIAM enzyme-specific profiles3.4.21.118
KEGG Ligand Database for Enzyme Nomenclature3.4.21.118
IUBMB Enzyme Nomenclature3.4.21.118
MEDLINEFind literature relating to
O60259, KLK8_HUMAN;  Q61955, KLK8_MOUSE;  O88780, KLK8_RAT;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-