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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.4.21.118
| Accepted Name |
|---|
| Kallikrein 8.
|
| Alternative Name(s) |
|---|
| Neuropsin. |
| Ovasin. |
| Serine protease 19. |
| TADG-14. |
| Tumor-associated differentially expressed gene 14. |
| Reaction catalysed |
|---|
| Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys |
| Comment(s) |
|---|
- Activated by removal of an N-terminal prepropeptide.
- The highest amidolytic activity is observed using Boc-Val-Pro-
Arg-|-7-amido-4-methylcoumarin, which is a substrate of alpha-
thrombin.
- Substrates lacking basic amino acids in the P1 position are not
cleaved.
- Degrades casein, fibronectin, gelatin, collagen type IV, fibrinogen,
and high-molecular-mass kininogen and is associated with diseases
such as ovarian cancer and Alzheimer's disease.
- Belongs to peptidase family S1A.
|
| Cross-references |
|---|
| PROSITE | PDOC00124 |
| BRENDA | 3.4.21.118 |
| EC2PDB | 3.4.21.118 |
| ExplorEnz | 3.4.21.118 |
| PRIAM enzyme-specific profiles | 3.4.21.118 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.118 |
| IUBMB Enzyme Nomenclature | 3.4.21.118 |
| IntEnz | 3.4.21.118 |
| MEDLINE | Find literature relating to 3.4.21.118 |
| MetaCyc | 3.4.21.118 |
| UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-