ENZYME entry: EC 3.4.21.119
| Accepted Name |
|---|
| Kallikrein 13.
|
| Alternative Name(s) |
|---|
| Epidermal growth factor-binding protein type B. |
| MGK-13. |
| PRECE. |
| PRECE-1. |
| Prorenin converting enzyme 1. |
| Prorenin-converting enzyme. |
| Proteinase P. |
| Reaction catalysed |
|---|
| Hydrolyzes mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg-|- pair in the N-terminus, to yield mature renin |
| Comment(s) |
|---|
- Specific for prorenin from the mouse submandibular gland, as prorenin
from the mouse kidney (Ren1) and human prorenin are not substrates.
- Site-directed mutagenesis studies have shown that the enzyme will
also cleave prorenin when Lys-Arg is replaced by Arg-Arg or Gln-Arg
but the rate of reaction is much slower when Lys-Lys is used.
- Also able to process pro-interleukin-1-beta (pro-IL-1-beta) in mouse
submandibular gland to form IL-1-beta.
- Belongs to peptidase family S1A.
|
| Cross-references |
|---|
| PROSITE | PDOC00124 |
| BRENDA | 3.4.21.119 |
| EC2PDB | 3.4.21.119 |
| ExplorEnz | 3.4.21.119 |
| PRIAM enzyme-specific profiles | 3.4.21.119 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.119 |
| IUBMB Enzyme Nomenclature | 3.4.21.119 |
| IntEnz | 3.4.21.119 |
| MEDLINE | Find literature relating to 3.4.21.119 |
| MetaCyc | 3.4.21.119 |
| UniProtKB/Swiss-Prot |
|
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