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ENZYME

ENZYME entry: EC 3.4.21.119

PURL: https://purl.expasy.org/enzyme/EC/3.4.21.119
Accepted Name
kallikrein 13
Alternative Name(s)
epidermal growth factor-binding protein type B
mGK-13
PRECE
PRECE-1
prorenin-converting enzyme
prorenin converting enzyme 1
proteinase P
Reaction catalysed
Hydrolyzes mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg-|- pair in the N-terminus, to yield mature renin
Comment(s)
  • Specific for prorenin from the mouse submandibular gland, as prorenin from the mouse kidney (Ren1) and human prorenin are not substrates.
  • Site-directed mutagenesis studies have shown that the enzyme will also cleave prorenin when Lys-Arg is replaced by Arg-Arg or Gln-Arg but the rate of reaction is much slower when Lys-Lys is used.
  • Also able to process pro-interleukin-1beta (pro-IL-1beta) in mouse submandibular gland to form IL-1beta.
  • Belongs to peptidase family S1A.
Cross-references
BRENDA3.4.21.119
EC2PDB3.4.21.119
ExplorEnz3.4.21.119
KEGG Ligand Database for Enzyme Nomenclature3.4.21.119
IUBMB Enzyme Nomenclature3.4.21.119
MEDLINEFind literature relating to 3.4.21.119
MetaCyc3.4.21.119
Rhea expert-curated reactions3.4.21.119
UniProtKB/Swiss-Prot
P36368, EGFB2_MOUSE

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