ENZYME entry: EC 3.4.21.119
Accepted Name |
Kallikrein 13.
|
Alternative Name(s) |
Epidermal growth factor-binding protein type B. |
MGK-13. |
PRECE. |
PRECE-1. |
Prorenin converting enzyme 1. |
Prorenin-converting enzyme. |
Proteinase P. |
Reaction catalysed |
Hydrolyzes mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg-|- pair in the N-terminus, to yield mature renin |
Comment(s) |
- Specific for prorenin from the mouse submandibular gland, as prorenin
from the mouse kidney (Ren1) and human prorenin are not substrates.
- Site-directed mutagenesis studies have shown that the enzyme will
also cleave prorenin when Lys-Arg is replaced by Arg-Arg or Gln-Arg
but the rate of reaction is much slower when Lys-Lys is used.
- Also able to process pro-interleukin-1-beta (pro-IL-1-beta) in mouse
submandibular gland to form IL-1-beta.
- Belongs to peptidase family S1A.
|
Cross-references |
PROSITE | PDOC00124 |
BRENDA | 3.4.21.119 |
EC2PDB | 3.4.21.119 |
ExplorEnz | 3.4.21.119 |
PRIAM enzyme-specific profiles | 3.4.21.119 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.119 |
IUBMB Enzyme Nomenclature | 3.4.21.119 |
IntEnz | 3.4.21.119 |
MEDLINE | Find literature relating to 3.4.21.119 |
MetaCyc | 3.4.21.119 |
UniProtKB/Swiss-Prot |
|
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