ENZYME entry: EC 3.4.21.120
| Accepted Name |
|---|
| oviductin.
|
| Alternative Name(s) |
|---|
| oviductal protease. |
| ovochymase-2. |
| Reaction catalysed |
|---|
| Preferential cleavage at 371-Gly-Ser-Arg-|-Trp-374 of glycoprotein gp43 in Xenopus laevis coelemic egg envelope to yield gp41 |
| Comment(s) |
|---|
- The egg envelope of Xenopus laevis is modified during transit of the
egg through the pars rectus oviduct, changing the egg envelope from
an unfertilizable form to a fertilizable form.
- This process involves the conversion of glycoprotein gp43 to gp41
(ZPC) by the pars recta protease oviductin.
- It is thought that the enzymatically active protease molecule
comprises the N-terminal protease domain coupled to two C-terminal
CUB domains, which are related to the mammalian spermadhesin
molecules implicated in mediating sperm-envelope interactions.
- Also found in Bufo japonicus.
- Belongs to peptidase family S1.
|
| Cross-references |
|---|
| BRENDA | 3.4.21.120 |
| EC2PDB | 3.4.21.120 |
| ExplorEnz | 3.4.21.120 |
| PRIAM enzyme-specific profiles | 3.4.21.120 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.120 |
| IUBMB Enzyme Nomenclature | 3.4.21.120 |
| IntEnz | 3.4.21.120 |
| MEDLINE | Find literature relating to 3.4.21.120 |
| MetaCyc | 3.4.21.120 |
| Rhea expert-curated reactions | 3.4.21.120 |
| UniProtKB/Swiss-Prot |
|
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