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ENZYME

ENZYME entry: EC 3.4.21.120

PURL: https://purl.expasy.org/enzyme/EC/3.4.21.120
Accepted Name
oviductin
Alternative Name(s)
oviductal protease
ovochymase-2
Reaction catalysed
Preferential cleavage at 371-Gly-Ser-Arg-|-Trp-374 of glycoprotein gp43 in Xenopus laevis coelemic egg envelope to yield gp41
Comment(s)
  • The egg envelope of Xenopus laevis is modified during transit of the egg through the pars rectus oviduct, changing the egg envelope from an unfertilizable form to a fertilizable form.
  • This process involves the conversion of glycoprotein gp43 to gp41 (ZPC) by the pars recta protease oviductin.
  • It is thought that the enzymatically active protease molecule comprises the N-terminal protease domain coupled to two C-terminal CUB domains, which are related to the mammalian spermadhesin molecules implicated in mediating sperm-envelope interactions.
  • Also found in Bufo japonicus.
  • Belongs to peptidase family S1.
Cross-references
BRENDA3.4.21.120
EC2PDB3.4.21.120
ExplorEnz3.4.21.120
KEGG Ligand Database for Enzyme Nomenclature3.4.21.120
IUBMB Enzyme Nomenclature3.4.21.120
MEDLINEFind literature relating to 3.4.21.120
MetaCyc3.4.21.120
Rhea expert-curated reactions3.4.21.120
UniProtKB/Swiss-Prot
Q90WD8, OVCH2_BUFJAQ66TN7, OVCH2_RHIAEP79953, OVCH2_XENLA

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