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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.21.19

Accepted Name
Glutamyl endopeptidase.
Alternative Name(s)
Endoproteinase Glu-C.
Protease V8.
Staphylococcal serine proteinase.
V8 proteinase.
Reaction catalysed
Preferential cleavage: Glu-|-Xaa, Asp-|-Xaa
Comment(s)
  • In appropriate buffer the specificity is restricted to Glu-|-Xaa.
  • Bonds involving bulky side-chains of hydrophobic amino acids are cleaved at a lower rate.
  • Belongs to peptidase family S1B.
Cross-references
PROSITEPDOC00571
BRENDA3.4.21.19
EC2PDB3.4.21.19
ExplorEnz3.4.21.19
PRIAM enzyme-specific profiles3.4.21.19
KEGG Ligand Database for Enzyme Nomenclature3.4.21.19
IUBMB Enzyme Nomenclature3.4.21.19
IntEnz3.4.21.19
MEDLINEFind literature relating to 3.4.21.19
MetaCyc3.4.21.19
UniProtKB/Swiss-Prot
P0C0Q1, GSEA_STAEP;  Q5HN75, GSEA_STAEQ;  P0C0Q2, GSEA_STAES;  
P80057, GSEP_BACLD;  Q2FZL2, SSPA_STAA8;  Q5HH35, SSPA_STAAC;  
Q99V45, SSPA_STAAM;  Q7A6A6, SSPA_STAAN;  Q6GI34, SSPA_STAAR;  
Q6GAG4, SSPA_STAAS;  P0C1U8, SSPA_STAAU;  Q8NX98, SSPA_STAAW;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
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