A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.21.26

Accepted Name
Prolyl oligopeptidase.
Alternative Name(s)
Post-proline cleaving enzyme.
Post-proline endopeptidase.
Prolyl endopeptidase.
Reaction catalysed
Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides
Comment(s)
  • Found in vertebrates, plants and Flavobacterium.
  • Generally cytosolic, commonly activated by thiol compounds.
  • Belongs to peptidase family S9A.
  • Formerly EC 3.4.22.18.
Cross-references
PROSITEPDOC00587
BRENDA3.4.21.26
EC2PDB3.4.21.26
ExplorEnz3.4.21.26
PRIAM enzyme-specific profiles3.4.21.26
KEGG Ligand Database for Enzyme Nomenclature3.4.21.26
IUBMB Enzyme Nomenclature3.4.21.26
IntEnz3.4.21.26
MEDLINEFind literature relating to 3.4.21.26
MetaCyc3.4.21.26
UniProtKB/Swiss-Prot
E2JFG1, POPA_AMABI;  H2E7Q7, POPA_GALM3;  E2JFG2, POPB_AMABI;  
H2E7Q8, POPB_GALM3;  Q06903, PPCE_AERHY;  Q9XTA2, PPCE_BOVIN;  
Q86AS5, PPCE_DICDI;  P27028, PPCE_ELIME;  P48147, PPCE_HUMAN;  
Q9QUR6, PPCE_MOUSE;  P23687, PPCE_PIG;  O70196, PPCE_RAT;  
P27195, PPCF_ELIMR;  A5D7B7, SEPR_BOVIN;  Q12884, SEPR_HUMAN;  
P97321, SEPR_MOUSE;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-