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ENZYME entry: EC

Accepted Name
Alternative Name(s)
collagenolytic protease.
Reaction catalysed
Hydrolysis of proteins, with broad specificity for peptide bonds. Native collagen is cleaved about 75% of the length of the molecule from the N-terminus. Low activity on small molecule substrates of both trypsin and chymotrypsin
  • From hepatopancreas of the fiddler crab (Uca pugilator).
  • Other serine endopeptidases that degrade collagen, but are not listed separately here, include a second endopeptidase from U.pugilator, digestive enzymes from other decapod crustacea, and an enzyme from the fungus Entomophthora coronata.
  • Belongs to peptidase family S1.
PRIAM enzyme-specific profiles3.4.21.32
KEGG Ligand Database for Enzyme Nomenclature3.4.21.32
IUBMB Enzyme Nomenclature3.4.21.32
MEDLINEFind literature relating to
Rhea expert-curated reactions3.4.21.32
P34153, COG1_CHIOP;  P20731, COG1_PARCM;  P81609, COG2_CARMA;  
P34154, COG2_CHIOP;  P34155, COG3_CHIOP;  P20732, COGA_PARCM;  
P20733, COGB_PARCM;  P20734, COGC_PARCM;  P00771, COGS_LEPPG;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
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