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ENZYME entry: EC 3.4.21.37

Accepted Name
leukocyte elastase.
Alternative Name(s)
bone marrow serine protease.
lysosomal elastase.
medullasin.
neutrophil elastase.
Reaction catalysed
Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa
Comment(s)
  • Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.4.7 and EC 3.4.21.11.
Cross-references
BRENDA3.4.21.37
EC2PDB3.4.21.37
ExplorEnz3.4.21.37
PRIAM enzyme-specific profiles3.4.21.37
KEGG Ligand Database for Enzyme Nomenclature3.4.21.37
IUBMB Enzyme Nomenclature3.4.21.37
IntEnz3.4.21.37
MEDLINEFind literature relating to 3.4.21.37
MetaCyc3.4.21.37
Rhea expert-curated reactions3.4.21.37
UniProtKB/Swiss-Prot
P08246, ELNE_HUMAN;  Q3UP87, ELNE_MOUSE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-