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ENZYME entry: EC 3.4.21.38

Accepted Name
Coagulation factor XIIa.
Alternative Name(s)
Hageman factor.
Reaction catalysed
Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa
Comment(s)
  • Also activates plasma prekallikrein and plasminogen.
  • Formed from the proenzyme, factor XII, by plasma kallikrein or factor XIIa.
  • Belongs to peptidase family S1.
Cross-references
PROSITEPDOC00124
BRENDA3.4.21.38
EC2PDB3.4.21.38
ExplorEnz3.4.21.38
PRIAM enzyme-specific profiles3.4.21.38
KEGG Ligand Database for Enzyme Nomenclature3.4.21.38
IUBMB Enzyme Nomenclature3.4.21.38
IntEnz3.4.21.38
MEDLINEFind literature relating to 3.4.21.38
MetaCyc3.4.21.38
Rhea expert-curated reactions3.4.21.38
UniProtKB/Swiss-Prot
P98140, FA12_BOVIN;  Q04962, FA12_CAVPO;  P00748, FA12_HUMAN;  
Q80YC5, FA12_MOUSE;  O97507, FA12_PIG;  D3ZTE0, FA12_RAT;  

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