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ENZYME entry: EC 3.4.21.43

Accepted Name
Classical-complement-pathway C3/C5 convertase.
Alternative Name(s)
C3 convertase.
C5 convertase.
Complement C2.
Reaction catalysed
Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b
Comment(s)
  • A complex of complement fragments C4b, C2a and C2b.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.44.
Cross-references
PROSITEPDOC00124
BRENDA3.4.21.43
EC2PDB3.4.21.43
ExplorEnz3.4.21.43
PRIAM enzyme-specific profiles3.4.21.43
KEGG Ligand Database for Enzyme Nomenclature3.4.21.43
IUBMB Enzyme Nomenclature3.4.21.43
IntEnz3.4.21.43
MEDLINEFind literature relating to 3.4.21.43
MetaCyc3.4.21.43
Rhea expert-curated reactions3.4.21.43
UniProtKB/Swiss-Prot
Q3SYW2, CO2_BOVIN;  Q863A0, CO2_GORGO;  P06681, CO2_HUMAN;  
P21180, CO2_MOUSE;  Q8SQ74, CO2_PANTR;  Q8SQ75, CO2_PONPY;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-