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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.21.46

Accepted Name
Complement factor D.
Alternative Name(s)
C3 convertase activator.
C3 proactivator convertase.
Reaction catalysed
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor
Comment(s)
  • A component of the alternative pathway of complement activation.
  • This reaction is analogous to the activation of complement component C2 by activated complement subcomponent C1s.
  • Belongs to peptidase family S1.
Cross-references
PROSITEPDOC00124
BRENDA3.4.21.46
EC2PDB3.4.21.46
ExplorEnz3.4.21.46
PRIAM enzyme-specific profiles3.4.21.46
KEGG Ligand Database for Enzyme Nomenclature3.4.21.46
IUBMB Enzyme Nomenclature3.4.21.46
IntEnz3.4.21.46
MEDLINEFind literature relating to 3.4.21.46
MetaCyc3.4.21.46
UniProtKB/Swiss-Prot
Q3T0A3, CFAD_BOVIN;  P00746, CFAD_HUMAN;  P03953, CFAD_MOUSE;  
P51779, CFAD_PIG;  P32038, CFAD_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-