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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 184.108.40.206
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|Alternative-complement-pathway C3/C5 convertase.
|Complement component C3/C5 convertase (alternative).|
|Complement factor B.|
|Properdin factor B.|
|Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to yield C5a and C5b|
- A bimolecular complex of complement fragment Bb with either C3b or
cobra venom factor; Bb contains the active site.
- Bb is formed by cleavage of proenzyme factor B by factor D.
- Cleavage of complement component C5 requires additional C3b which
binds C5 and renders it susceptible to cleavage by C3b,Bb complex.
- C3b,Bb is stabilized in plasma by factor P.
- Belongs to peptidase family S1.
|PRIAM enzyme-specific profiles||220.127.116.11|
|KEGG Ligand Database for Enzyme Nomenclature||18.104.22.168|
|IUBMB Enzyme Nomenclature||22.214.171.124|
|MEDLINE||Find literature relating to 126.96.36.199|
entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-