ENZYME entry: EC 3.4.21.47
Accepted Name |
Alternative-complement-pathway C3/C5 convertase.
|
Alternative Name(s) |
C3 convertase. |
C3 proactivator. |
C5 convertase. |
Complement component C3/C5 convertase (alternative). |
Complement factor B. |
Properdin factor B. |
Reaction catalysed |
Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to yield C5a and C5b |
Comment(s) |
- A bimolecular complex of complement fragment Bb with either C3b or
cobra venom factor; Bb contains the active site.
- Bb is formed by cleavage of proenzyme factor B by factor D.
- Cleavage of complement component C5 requires additional C3b which
binds C5 and renders it susceptible to cleavage by C3b,Bb complex.
- C3b,Bb is stabilized in plasma by factor P.
- Belongs to peptidase family S1.
|
Cross-references |
PROSITE | PDOC00124 |
BRENDA | 3.4.21.47 |
EC2PDB | 3.4.21.47 |
ExplorEnz | 3.4.21.47 |
PRIAM enzyme-specific profiles | 3.4.21.47 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.47 |
IUBMB Enzyme Nomenclature | 3.4.21.47 |
IntEnz | 3.4.21.47 |
MEDLINE | Find literature relating to 3.4.21.47 |
MetaCyc | 3.4.21.47 |
Rhea expert-curated reactions | 3.4.21.47 |
UniProtKB/Swiss-Prot |
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