A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.21.53

Accepted Name
Endopeptidase La.
Alternative Name(s)
ATP-dependent protease La.
ATP-dependent serine proteinase.
Reaction catalysed
Hydrolysis of proteins in presence of ATP
Comment(s)
  • ATP hydrolysis is linked with peptide bond hydrolysis.
  • Vanadate inhibits both reactions.
  • A similar enzyme occurs in animal mitochondria.
  • Belongs to peptidase family S16.
Cross-references
PROSITEPDOC00803
BRENDA3.4.21.53
EC2PDB3.4.21.53
ExplorEnz3.4.21.53
PRIAM enzyme-specific profiles3.4.21.53
KEGG Ligand Database for Enzyme Nomenclature3.4.21.53
IUBMB Enzyme Nomenclature3.4.21.53
IntEnz3.4.21.53
MEDLINEFind literature relating to 3.4.21.53
MetaCyc3.4.21.53
UniProtKB/Swiss-Prot
P37945, LON1_BACSU;  Q6ML73, LON1_BDEBA;  Q59185, LON1_BORBU;  
Q6AS16, LON1_DESPS;  A9B5N1, LON1_HERA2;  Q31GE9, LON1_HYDCU;  
P36773, LON1_MYXXA;  Q3A701, LON1_PELCD;  A9ETZ9, LON1_SORC5;  
A0LEE9, LON1_SYNFM;  Q72KS4, LON1_THET2;  P42425, LON2_BACSU;  
Q6MGP8, LON2_BDEBA;  O51558, LON2_BORBU;  Q6AK61, LON2_DESPS;  
A9B3R2, LON2_HERA2;  Q31FD3, LON2_HYDCU;  P36774, LON2_MYXXA;  
Q3A334, LON2_PELCD;  A9GBF1, LON2_SORC5;  A0LG61, LON2_SYNFM;  
Q72JM6, LON2_THET2;  A9GIS9, LON3_SORC5;  A9F8L0, LON4_SORC5;  
P93655, LONM1_ARATH;  Q54YV4, LONM1_DICDI;  Q550C8, LONM2_DICDI;  
Q9M9L8, LONM3_ARATH;  Q9M9L7, LONM4_ARATH;  Q754Q9, LONM_ASHGO;  
Q4X0Z7, LONM_ASPFU;  A2QCJ2, LONM_ASPNC;  Q59HJ6, LONM_BOVIN;  
A8XFM8, LONM_CAEBR;  O44952, LONM_CAEEL;  Q5A6N1, LONM_CANAL;  
B9WLN5, LONM_CANDC;  Q6FPE6, LONM_CANGA;  P0CQ17, LONM_CRYNB;  
P0CQ16, LONM_CRYNJ;  Q6BKJ4, LONM_DEBHA;  Q7KUT2, LONM_DROME;  
Q5AZT7, LONM_EMENI;  P36776, LONM_HUMAN;  Q6CNR9, LONM_KLULA;  
P93648, LONM_MAIZE;  Q8CGK3, LONM_MOUSE;  Q7S8C4, LONM_NEUCR;  
A2YQ56, LONM_ORYSI;  Q69UZ3, LONM_ORYSJ;  A4S6Y4, LONM_OSTLU;  
Q00WL5, LONM_OSTTA;  B7FSL4, LONM_PHATC;  A3M072, LONM_PICST;  
Q924S5, LONM_RAT;  Q09769, LONM_SCHPO;  Q6C0B5, LONM_YARLI;  
P36775, LONM_YEAST;  O64948, LONP2_ARATH;  Q755E4, LONP2_ASHGO;  
Q4WVD9, LONP2_ASPFU;  A2RAF6, LONP2_ASPNC;  Q3SX23, LONP2_BOVIN;  
A8Y3E2, LONP2_CAEBR;  Q9XW87, LONP2_CAEEL;  Q59YV0, LONP2_CANAL;  
B9WEC4, LONP2_CANDC;  Q5PQY6, LONP2_DANRE;  Q6BJJ8, LONP2_DEBHA;  
Q5BH58, LONP2_EMENI;  Q86WA8, LONP2_HUMAN;  Q6CWS4, LONP2_KLULA;  
P93647, LONP2_MAIZE;  Q9DBN5, LONP2_MOUSE;  Q7SA85, LONP2_NEUCR;  
B8BDV1, LONP2_ORYSI;  Q0J032, LONP2_ORYSJ;  Q2V573, LONP2_PICAN;  
A3LUF7, LONP2_PICST;  Q5R6M5, LONP2_PONAB;  Q3MIB4, LONP2_RAT;  
O04979, LONP2_SPIOL;  Q2TAF8, LONP2_XENLA;  Q6C0L7, LONP2_YARLI;  
B7GXS7, LON_ACIB3;  B3ERM8, LON_AMOA5;  Q2IIK1, LON_ANADE;  
O66605, LON_AQUAE;  Q2NJE3, LON_AYWBP;  P77810, LON_AZOBR;  
A8HYF7, LON_AZOC5;  A0RJ87, LON_BACAH;  B5RL78, LON_BORDL;  
P36772, LON_BRECH;  Q2YPX3, LON_BRUA2;  P0C113, LON_BRUAB;  
Q8YHC6, LON_BRUME;  Q8G0I7, LON_BRUSU;  P57549, LON_BUCAI;  
Q8K988, LON_BUCAP;  Q89A99, LON_BUCBP;  A4XJL4, LON_CALS8;  
A7ZEJ3, LON_CAMC1;  O69300, LON_CAMJE;  P0CAW0, LON_CAUVC;  
B8GX12, LON_CAUVN;  A9WGB5, LON_CHLAA;  B8G736, LON_CHLAD;  
Q9PK50, LON_CHLMU;  Q9Z9F4, LON_CHLPN;  B3QSJ7, LON_CHLT3;  
O84348, LON_CHLTR;  Q97FT9, LON_CLOAB;  A6LSV5, LON_CLOB8;  
B5Y8Q8, LON_COPPD;  Q11QT1, LON_CYTH3;  Q9RXG4, LON_DEIRA;  
B8F9K1, LON_DESAA;  B8J198, LON_DESDA;  A8ZX50, LON_DESOH;  
A4J7L6, LON_DESRM;  Q72CE6, LON_DESVH;  A5EWF3, LON_DICNV;  
B5YFG2, LON_DICT6;  P0A9M1, LON_ECOL6;  P0A9M0, LON_ECOLI;  
B2KCC0, LON_ELUMP;  P46067, LON_ERWAM;  A7HK39, LON_FERNB;  
B0S2N4, LON_FINM2;  A5FG89, LON_FLAJ1;  Q0RPW3, LON_FRAAA;  
B0TZA7, LON_FRAP2;  Q8RHK0, LON_FUSNN;  B5EDX8, LON_GEOBB;  
B3E7K2, LON_GEOLS;  Q39QP7, LON_GEOMG;  P43864, LON_HAEIN;  
B8CY71, LON_HALOH;  B0TFI9, LON_HELMI;  Q9ZJL3, LON_HELPJ;  
P55995, LON_HELPY;  Q1IPZ8, LON_KORVE;  A9KH99, LON_LACP7;  
Q1MS21, LON_LAWIP;  Q72UP9, LON_LEPIC;  A0L516, LON_MAGMM;  
Q469F5, LON_METBF;  B8EMF2, LON_METSB;  Q2NEP8, LON_METST;  
B3PN08, LON_MYCA5;  A5IYF2, LON_MYCAP;  P47481, LON_MYCGE;  
Q600B5, LON_MYCH2;  Q6KI22, LON_MYCMO;  Q6MTF4, LON_MYCMS;  
Q8EV77, LON_MYCPE;  P78025, LON_MYCPN;  Q4A696, LON_MYCS5;  
O31147, LON_MYCSM;  Q2GE60, LON_NEOSM;  Q3JBB6, LON_NITOC;  
B3CUN9, LON_ORITI;  A6LD45, LON_PARD8;  B2TFQ5, LON_PARPJ;  
Q6ME13, LON_PARUW;  Q180E4, LON_PEPD6;  B4RI01, LON_PHEZH;  
B2RII6, LON_PORG3;  A8F811, LON_PSELT;  O69177, LON_RHIME;  
Q1RID6, LON_RICBR;  Q92HZ1, LON_RICCN;  Q4ULN0, LON_RICFE;  
Q9ZD92, LON_RICPR;  Q68WS8, LON_RICTY;  A7NM80, LON_ROSCS;  
A8M1E8, LON_SALAI;  Q32JJ5, LON_SHIDS;  Q026Q2, LON_SOLUE;  
A8Z5Z0, LON_SULMW;  B2V6N0, LON_SULSY;  Q2LVS9, LON_SYNAS;  
Q0AWF3, LON_SYNWW;  O83536, LON_TREPA;  B1GZQ6, LON_UNCTG;  
B1AIY7, LON_UREP2;  P74956, LON_VIBPA;  B3CLB3, LON_WOLPP;  
Q5H432, LON_XANOR;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-