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ENZYME entry: EC 3.4.21.59

Accepted Name
tryptase.
Alternative Name(s)
lung tryptase.
mast cell protease II.
mast cell tryptase.
pituitary tryptase.
skin tryptase.
Reaction catalysed
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin
Comment(s)
  • Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules.
  • Not inhibited by alpha-1-proteinase inhibitor of alpha-2- macroglobulin.
  • Belongs to peptidase family S1.
Cross-references
BRENDA3.4.21.59
EC2PDB3.4.21.59
ExplorEnz3.4.21.59
PRIAM enzyme-specific profiles3.4.21.59
KEGG Ligand Database for Enzyme Nomenclature3.4.21.59
IUBMB Enzyme Nomenclature3.4.21.59
IntEnz3.4.21.59
MEDLINEFind literature relating to 3.4.21.59
MetaCyc3.4.21.59
Rhea expert-curated reactions3.4.21.59
UniProtKB/Swiss-Prot
Q15661, TRYB1_HUMAN;  Q02844, TRYB1_MOUSE;  P27435, TRYB1_RAT;  
P20231, TRYB2_HUMAN;  P21845, TRYB2_MOUSE;  P50343, TRYB2_RAT;  
Q9BZJ3, TRYD_HUMAN;  P15944, TRYT_CANLF;  P50342, TRYT_MERUN;  
Q9N2D1, TRYT_PIG;  Q9XSM2, TRYT_SHEEP;  

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