ENZYME entry: EC 3.4.21.59
Accepted Name |
Tryptase.
|
Alternative Name(s) |
Lung tryptase. |
Mast cell protease II. |
Mast cell tryptase. |
Pituitary tryptase. |
Skin tryptase. |
Reaction catalysed |
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin |
Comment(s) |
- Occurs as a tetrameric molecule with high affinity for heparin,
in mast cell granules.
- Not inhibited by alpha-1-proteinase inhibitor of alpha-2-
macroglobulin.
- Belongs to peptidase family S1.
|
Cross-references |
PROSITE | PDOC00124 |
BRENDA | 3.4.21.59 |
EC2PDB | 3.4.21.59 |
ExplorEnz | 3.4.21.59 |
PRIAM enzyme-specific profiles | 3.4.21.59 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.59 |
IUBMB Enzyme Nomenclature | 3.4.21.59 |
IntEnz | 3.4.21.59 |
MEDLINE | Find literature relating to 3.4.21.59 |
MetaCyc | 3.4.21.59 |
Rhea expert-curated reactions | 3.4.21.59 |
UniProtKB/Swiss-Prot |
Q15661, TRYB1_HUMAN; | Q02844, TRYB1_MOUSE; | P27435, TRYB1_RAT; |
P20231, TRYB2_HUMAN; | P21845, TRYB2_MOUSE; | P50343, TRYB2_RAT; |
Q9BZJ3, TRYD_HUMAN; | P15944, TRYT_CANLF; | P50342, TRYT_MERUN; |
Q9N2D1, TRYT_PIG; | Q9XSM2, TRYT_SHEEP; |
|
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UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
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