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ENZYME entry: EC 3.4.21.62

Accepted Name
Subtilisin.
Reaction catalysed
Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides
Comment(s)
  • Subtilisin is a serine endopeptidase that evolved independently of chymotrypsin.
  • It contains no cysteine residues (although these are found in homologous enzymes).
  • Species variants include subtilisin BPN' (also subtilisin B, subtilopeptidase C, nagarse, nagarse proteinase, subtilisin Novo, bacterial proteinase Novo) and subtilisin Carlsberg (subtilisin A, subtilopeptidase A, alcalase Novo).
  • Similar enzymes are produced by various Bacillus subtilis strains and other Bacillus species.
  • Belongs to peptidase family S8.
  • Formerly EC 3.4.4.16 and EC 3.4.21.14.
Cross-references
PROSITEPDOC00125
BRENDA3.4.21.62
EC2PDB3.4.21.62
ExplorEnz3.4.21.62
PRIAM enzyme-specific profiles3.4.21.62
KEGG Ligand Database for Enzyme Nomenclature3.4.21.62
IUBMB Enzyme Nomenclature3.4.21.62
IntEnz3.4.21.62
MEDLINEFind literature relating to 3.4.21.62
MetaCyc3.4.21.62
Rhea expert-curated reactions3.4.21.62
UniProtKB/Swiss-Prot
P09230, AEP_YARLI;  A0A509AKI1, PIMM2_PLABA;  Q8I0V0, SUB1_PLAF7;  
O61142, SUB1_PLAFA;  W7K9M0, SUB1_PLAFO;  Q8IHZ5, SUB2_PLAF7;  
O97364, SUB2_PLAFA;  Q9Y008, SUB2_PLAFP;  Q8I430, SUB3_PLAF7;  
P29599, SUBB_LEDLE;  P00780, SUBC_BACLI;  P00781, SUBD_BACLI;  
P35835, SUBN_BACNA;  P29600, SUBS_LEDLE;  P00782, SUBT_BACAM;  
P07518, SUBT_BACPU;  P28842, SUBT_BACS9;  P00783, SUBT_BACSA;  
P04189, SUBT_BACSU;  P29142, SUBT_GEOSE;  Q5JIZ5, TKSP_THEKO;  

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