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ENZYME entry: EC 3.4.21.62
| Accepted Name |
|---|
| subtilisin.
|
| Reaction catalysed |
|---|
| Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides |
| Comment(s) |
|---|
- Subtilisin is a serine endopeptidase that evolved independently of
chymotrypsin.
- It contains no cysteine residues (although these are found in
homologous enzymes).
- Species variants include subtilisin BPN' (also subtilisin B,
subtilopeptidase C, nagarse, nagarse proteinase, subtilisin Novo,
bacterial proteinase Novo) and subtilisin Carlsberg (subtilisin A,
subtilopeptidase A, alcalase Novo).
- Similar enzymes are produced by various Bacillus subtilis strains and
other Bacillus species.
- Belongs to peptidase family S8.
- Formerly EC 3.4.4.16 and EC 3.4.21.14.
|
| Cross-references |
|---|
| BRENDA | 3.4.21.62 |
| EC2PDB | 3.4.21.62 |
| ExplorEnz | 3.4.21.62 |
| PRIAM enzyme-specific profiles | 3.4.21.62 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.62 |
| IUBMB Enzyme Nomenclature | 3.4.21.62 |
| IntEnz | 3.4.21.62 |
| MEDLINE | Find literature relating to 3.4.21.62 |
| MetaCyc | 3.4.21.62 |
| Rhea expert-curated reactions | 3.4.21.62 |
| UniProtKB/Swiss-Prot |
| P09230, AEP_YARLI; | A0A509AKI1, PIMM2_PLABA; | Q8I0V0, SUB1_PLAF7; |
| O61142, SUB1_PLAFA; | W7K9M0, SUB1_PLAFO; | Q8IHZ5, SUB2_PLAF7; |
| O97364, SUB2_PLAFA; | Q9Y008, SUB2_PLAFP; | Q8I430, SUB3_PLAF7; |
| P29599, SUBB_LEDLE; | P00780, SUBC_BACLI; | P00781, SUBD_BACLI; |
| P35835, SUBN_BACNA; | P29600, SUBS_LEDLE; | P00782, SUBT_BACAM; |
| P07518, SUBT_BACPU; | P28842, SUBT_BACS9; | P00783, SUBT_BACSA; |
| P04189, SUBT_BACSU; | P29142, SUBT_GEOSE; | Q5JIZ5, TKSP_THEKO; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
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