ENZYME entry: EC 3.4.21.62
Accepted Name |
subtilisin.
|
Reaction catalysed |
Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides |
Comment(s) |
- Subtilisin is a serine endopeptidase that evolved independently of
chymotrypsin.
- It contains no cysteine residues (although these are found in
homologous enzymes).
- Species variants include subtilisin BPN' (also subtilisin B,
subtilopeptidase C, nagarse, nagarse proteinase, subtilisin Novo,
bacterial proteinase Novo) and subtilisin Carlsberg (subtilisin A,
subtilopeptidase A, alcalase Novo).
- Similar enzymes are produced by various Bacillus subtilis strains and
other Bacillus species.
- Belongs to peptidase family S8.
- Formerly EC 3.4.4.16 and EC 3.4.21.14.
|
Cross-references |
BRENDA | 3.4.21.62 |
EC2PDB | 3.4.21.62 |
ExplorEnz | 3.4.21.62 |
PRIAM enzyme-specific profiles | 3.4.21.62 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.62 |
IUBMB Enzyme Nomenclature | 3.4.21.62 |
IntEnz | 3.4.21.62 |
MEDLINE | Find literature relating to 3.4.21.62 |
MetaCyc | 3.4.21.62 |
Rhea expert-curated reactions | 3.4.21.62 |
UniProtKB/Swiss-Prot |
P09230, AEP_YARLI; | A0A509AKI1, PIMM2_PLABA; | Q8I0V0, SUB1_PLAF7; |
O61142, SUB1_PLAFA; | W7K9M0, SUB1_PLAFO; | Q8IHZ5, SUB2_PLAF7; |
O97364, SUB2_PLAFA; | Q9Y008, SUB2_PLAFP; | Q8I430, SUB3_PLAF7; |
P29599, SUBB_LEDLE; | P00780, SUBC_BACLI; | P00781, SUBD_BACLI; |
P35835, SUBN_BACNA; | P29600, SUBS_LEDLE; | P00782, SUBT_BACAM; |
P07518, SUBT_BACPU; | P28842, SUBT_BACS9; | P00783, SUBT_BACSA; |
P04189, SUBT_BACSU; | P29142, SUBT_GEOSE; | Q5JIZ5, TKSP_THEKO; |
|
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